Elevated levels of serum sialic acid and C-reactive protein: markers of systemic inflammation in patients with chronic obstructive pulmonary disease

Sirsikar, Mangala; Pinnelli, Venkata Bharat Kumar; Raghavendra, D

doi:10.18203/2320-6012.ijrms20160811

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…They showed that salivary SA levels were highest in the COPD group, followed by the periodontitis group, and the lowest in the healthy group. Sirsikar et al [ 6 ] suggested that CRP in association with TSA is increased as a marker of systemic inflammation in COPD. Hence measurement of CRP and TSA simultaneously can be regarded as a marker of systemic inflammation and are helpful for the monitoring and management of COPD.…”

Section: Discussionmentioning

confidence: 99%

“…In COPD patients, who have extensive pulmonary inflammation, TSA levels also increase as a marker of systemic inflammation. [ 6 ] Therefore, serum SA levels can be used as an indicator of acute phase response in COPD patients. Several studies have reported serum SA levels [ 7 ] and serum prolidase enzyme activity [ 8 , 9 ] in various inflammatory conditions.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD

Uysal

Teksoz²,

Aksan³

et al. 2022

Medicine

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Our aim in this study was to evaluate the prognostic significance of sialic acid (SA) and prolidase activity and to evaluate the association between airflow obstruction severity and these parameters in chronic obstructive pulmonary disease (COPD) patients.Ninety-four patients (84 M, 10 F) and 34 healthy subjects (19 M, 15 F) were included into the study. COPD staging was performed to COPD patients according to new global initiative for chronic obstructive lung disease criteria which includes pulmonary function tests, symptoms and hospitalization; COPD patients were divided into 4 subgroups as group A (n = 25), group B (n = 19), group C (n = 20), and group D (n = 28).SA and C-reactive protein levels were significantly higher than the control group in all COPD groups. SA levels were significantly higher in group B patients than the control and group A. Prolidase activity was significantly lower than control group in total COPD groups (P < .05). There was a weak negative correlation between SA and forced vital capacity (r = -0.217, P = .038) and forced expiratory volume in 1 second (FEV1) (r = -0.210, P = .045), whereas weak positive correlation was present between SA and Creactive protein (r = 0.247, P = .018) in all patient groups. There was weak positive correlation between prolidase and FEV1 (r = 0.222, P = .033) and FEV1/forced vital capacity (r = 0.230, P = .027).Our study shows that systemic inflammation, prolidase activity, and SA levels in stable COPD patients are associated with airflow obstruction severity. In addition to the prolidase activity; SA levels might be associated with inflammation. Abbreviations: COPD = chronic obstructive pulmonary disease, CRP = C-reactive protein, FEV1 = forced expiratory volume in 1 second, FVC = forced vital capacity, GOLD = global initiative for chronic obstructive lung disease, mMRC = modified Medical Research Council, NA = neurominadase, PFT = pulmonary function tests, SA = sialic acid, TSA = total SA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD

Uysal

Teksoz²,

Aksan³

et al. 2022

Medicine

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“…30 Plasma samples from patients (16 female; 14 male) with an average age of 65 ± 22 with CVD were selected and purchased from the BioIVT biobank along with 30 age and sex matched healthy controls with an average age of 60 ± 13. Samples were chosen from volunteers that had one or multiple diagnosed CVDs including: hypertension, hypercholesterolemia, atrial fibrillation, congestive heart failure, coronary artery disease, but no other health conditions that could otherwise affect plasma sialic acid concentration such as type-2 diabetes [ 25 ], arthritis [ 26 ] or chronic obstructive pulmonary disorder (COPD) [ 27 ]. These conditions were chosen based on a literature search for health conditions associated with elevated plasma concentrations of sialic acid.…”

Section: Methodsmentioning

confidence: 99%

Elevated concentrations of Neu5Ac and Neu5,9Ac2 in human plasma: potential biomarkers of cardiovascular disease

Cheeseman,

Badia,

Elgood-Hunt

et al. 2023

Glycoconj J

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Cardiovascular disease (CVD) is a group of health conditions affecting the heart and vascular system with very high prevalence and mortality rates. The presence of CVD is characterised by high levels of inflammation which have previously been associated with increased plasma concentrations of N-acetyl neuraminic acid (Neu5Ac). While Neu5Ac has been studied in the context of CVD, Neu5,9Ac2 has not, despite being the second most abundant sialic acid in human plasma. A small-scale pilot study of thirty plasma samples from patients with diagnosed CVD, and thirty age and sex-matched healthy controls, was designed to gain insight into sialic acids as biomarkers for CVD and potential future areas of study. Each sample was assayed for Neu5Ac and Neu5,9Ac2 concentrations. Mean Neu5Ac and Neu5,9Ac2 concentrations were significantly elevated in patients with CVD compared to healthy controls (Neu5Ac: P < 0.001; Neu5,9Ac2: P < 0.04). Receiver operator curve (ROC) analysis indicated that both Neu5Ac and Neu5,9Ac2 have reasonable predictive power for the presence of CVD (Neu5Ac AUC: 0.86; Neu5,9Ac2 AUC: 0.71). However, while Neu5Ac had both good sensitivity (0.82) and specificity (0.81), Neu5,9Ac2 had equivalent specificity (0.81) but very poor sensitivity (0.44). A combination marker of Neu5Ac + Neu5,9Ac2 showed improvement over Neu5Ac alone in terms of predictive power (AUC: 0.93), sensitivity (0.87), and specificity (0.90). Comparison to a known inflammatory marker, high sensitivity c-reactive protein (hs-CRP: P-value: NS, ROC:0.50) was carried out, showing that both Neu5Ac and Neu5,9Ac2 outperformed this marker. Further to this, hs-CRP values were combined with the three different sialic acid markers to determine any effect on the AUC values. A slight improvement in AUC was noted for each of the combinations, with Neu5Ac + Neu5,9Ac2 + hs-CRP giving the best AUC of 0.97 overall. Thus, Neu5Ac would appear to offer good potential as a predictive marker for the presence of CVD, which the addition of Neu5,9Ac2 predictive power improves, with further improvement seen by the addition of hs-CRP.

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Goblet, Club and Alveolar Cells: Front-Line Defenders of the Airways in Chronic Obstructive Pulmonary Disease, a Most Common Lung Disease in Miners

Pingle,

Sherekar,

Thakkar

et al. 2022

Springer Geology

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Elevated levels of serum sialic acid and C-reactive protein: markers of systemic inflammation in patients with chronic obstructive pulmonary disease

Cited by 3 publications

References 22 publications

Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD

Relationship between serum sialic acid levels and prolidase activity with airflow obstruction in patients with COPD

Elevated concentrations of Neu5Ac and Neu5,9Ac2 in human plasma: potential biomarkers of cardiovascular disease

Goblet, Club and Alveolar Cells: Front-Line Defenders of the Airways in Chronic Obstructive Pulmonary Disease, a Most Common Lung Disease in Miners

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