Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells

Woo, Kyung Jin; Lee, Tae Jin; Lee, Sang‐Han; Lee, Jin-Man; Seo, Ji-Hyung; Jeong, Yong-Jin; Park, Jong‐Wook; Kwon, Taeg Kyu

doi:10.1016/j.bcp.2006.09.015

Cited by 60 publications

(34 citation statements)

References 31 publications

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“…It was reported that human caspase-4, which is also a resident of the ER, is the counterpart of murine caspase-12 and is activated by ER stress (21). We recently observed that the suppression of CHOP by CHOP siRNA attenuated resveratrol-induced apoptosis (24). In the present study, we provide evidence that the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis.…”

Section: Discussionsupporting

confidence: 69%

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Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

Park

Woo²,

Lee³

et al. 2007

Oncol Rep

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Abstract. Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, was measured by FACS analysis. Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2α (eIF-2α), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding proteinhomologous protein (CHOP). In addition, resveratrol induced up-regulation of glucose-regulated protein (GRP)-78, suggesting the induction of ER stress. Furthermore, the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis. Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis.

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Section: Discussionsupporting

confidence: 69%

“…Recently, our group reported that resveratrol-induced apoptosis was attenuated in cells transfected with CHOP siRNA (24). These data suggest that resveratrol-induced CHOP up-regulation may be involved, at least in part, in resveratrol-induced apoptosis.…”

Section: The Role Of Er Stress In Resveratrol-induced Apoptosis Of Htmentioning

confidence: 91%

Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

Park

Woo²,

Lee³

et al. 2007

Oncol Rep

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“…80 Park et al reported that resveratrol induces endoplasmic reticulum stress in HT 29 cells as seen from the upregulation of glucose-regulated protein (GRP)-78 and other markers of ER stress. 81 Resveratrol also induces CCAAT/ enhancer-binding protein-homologous protein (CHOP) in HT 29 cells 82 and inhibits the telomerase activity in HT-29 and WiDr cells. 83 Another report by Mohan et al suggested that resveratrol treatment activates caspase-2, which in turn triggers mitochondrial apoptotic events by inducing conformational changes in Bax/ Bak with subsequent release of cytochrome c, apoptosis-inducing factor and endonuclease G. 84 Resveratrol also produced growth inhibition and G 2 /M arrest in Caco-2 cells.…”

Section: Gastrointestinal and Colorectal Cancermentioning

confidence: 99%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

473

339

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Extensive research within the last decade has revealed that most chronic illnesses such as cancer, cardiovascular and pulmonary diseases, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. Thus mono-targeted therapies developed for the last two decades for these diseases have proven to be unsafe, ineffective and expensive. Although fruits and vegetables are regarded to have therapeutic potential against chronic illnesses, neither their active component nor the mechanism of action is well understood. Resveratrol (trans-3, 5, 4'-trihydroxystilbene), a component of grapes, berries, peanuts and other traditional medicines, is one such polyphenol that has been shown to mediate its effects through modulation of many different pathways. This stilbene has been shown to bind to numerous cell-signaling molecules such as multi drug resistance protein, topoisomerase II, aromatase, DNA polymerase, estrogen receptors, tubulin and F1-ATPase. Resveratrol has also been shown to activate various transcription factor (e.g., NFκB, STAT3, HIF-1α, β-catenin and PPAR-γ), suppress the expression of antiapoptotic gene products (e.g., Bcl-2, Bcl-X L , XIAP and survivin), inhibit protein kinases (e.g., src, PI3K, JNK and AKT), induce antioxidant enzymes (e.g., catalase, superoxide dismutase and hemoxygenase-1), suppress the expression of inflammatory biomarkers (e.g., TNF, COX-2, iNOS and CRP), inhibit the expression of angiogenic and metastatic gene products (e.g., MMPs, VEGF, cathepsin D and ICAM-1), and modulate cell cycle regulatory genes (e.g., p53, Rb, PTEN, cyclins and CDKs). Numerous animal studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential.

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“…1,2 Resveratrol inhibits cancer cell growth in many cell lines, including cancers of the lung, prostate, colon, breast and ovaries. [3][4][5][6][7][8][9][10][11][12][13][14] Resveratrol also reduces tumor incidence in animal models by interfering with carcinogenesis through a wide array of anti-cancer actions. Several animal studies have demonstrated the ability of resveratrol to inhibit prostate cancer development by downregulating androgen receptors, inducing apoptosis/cell cycle arrest and inhibiting disease progression.…”

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confidence: 99%

Red wine consumption and risk of prostate cancer: The California Men's Health Study

Chao

Haque

Eeden

et al. 2009

Intl Journal of Cancer

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Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine intake on the risk of prostate cancer using data prospectively collected in the California Men's Health Study (CMHS). CMHS is a multiethnic cohort of 84,170 men aged 45-69 years who were members of the Kaiser Permanente Southern and Northern California Health Plans. Information on demographic and lifestyle factors was collected using mailed questionnaires between 2002 and 2003. We used Cox models to estimate the effect of red wine on prostate cancer risk, adjusting for potential confounders. A total of 1,340 incident prostate cancer cases identified from Surveillance, Epidemiology and End Result-affiliated cancer registries were included in the analyses. We did not find a clear association between red wine intake and risk of prostate cancer. Hazard ratio (HR) estimates for consuming <1 drink/week, 1 drink/week but <1 drink/day and 1 drink/day were 0.89, 95% confidence interval (0.74-1.07), 0.99 (0.83-1.17) and 0.88 (0.70-1.12), respectively. Further, we observed no linear dose response. The lack of association for red wine intake was consistently observed when we restricted the analyses to those with and without a history of PSA screening. In addition, we also did not observe any association with prostate cancer for beer, white wine, liquor or combined alcoholic beverage intake (HR for combined alcoholic beverage intake of 5 drinks/day 5 1.16 (0.83-1.63). Neither red wine nor total alcohol consumption were associated with prostate cancer risk in this population of moderate drinkers.Red wine is a rich source of polyphenol antioxidants such as resveratrol. Recently, resveratrol has received considerable attention because of its potent anti-cancer properties.

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Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells

Cited by 60 publications

References 31 publications

Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

Resveratrol: A multitargeted agent for age-associated chronic diseases

Red wine consumption and risk of prostate cancer: The California Men's Health Study

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