Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

Park, Jong‐Wook; Woo, Kyung Jin; Lee, Jung-Tae; Lim, Jun Hee; Lee, Tae-Jin; Kim, Sang Hyun; Choi, Yung Hyun; Kwon, Taeg Kyu

doi:10.3892/or.18.5.1269

Cited by 55 publications

(54 citation statements)

References 26 publications

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“…Strikingly, the altered epigenetic acetylation status did not affect Atg7, which points to a regulatory mechanism that protects Atg genes from hypoacetylation [171]. Resveratrol-induced autophagy might also involve the induction of ER stress as resveratrol has been shown to induce several ER stress markers, e.g., eukaryotic translation initiation factor 2α (eIF2α) phosphorylation, X-box-binding protein 1 splicing and CHOP (C/EBP homologous protein) expression [172]. In line with the notion that autophagy is important in slowing down the ageing process, a decline in formation and elimination of autophagosomes is often observed in ageing cells [173].…”

Section: Autophagy and Ageingmentioning

confidence: 99%

Autophagy: for better or for worse

et al. 2011

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Autophagy is a lysosomal degradation pathway that degrades damaged or superfluous cell components into basic biomolecules, which are then recycled back into the cytosol. In this respect, autophagy drives a flow of biomolecules in a continuous degradation-regeneration cycle. Autophagy is generally considered a pro-survival mechanism protecting cells under stress or poor nutrient conditions. Current research clearly shows that autophagy fulfills numerous functions in vital biological processes. It is implicated in development, differentiation, innate and adaptive immunity, ageing and cell death. In addition, accumulating evidence demonstrates interesting links between autophagy and several human diseases and tumor development. Therefore, autophagy seems to be an important player in the life and death of cells and organisms. Despite the mounting knowledge about autophagy, the mechanisms through which the autophagic machinery regulates these diverse processes are not entirely understood. In this review, we give a comprehensive overview of the autophagic signaling pathway, its role in general cellular processes and its connection to cell death. In addition, we present a brief overview of the possible contribution of defective autophagic signaling to disease.

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Section: Autophagy and Ageingmentioning

confidence: 99%

Autophagy: for better or for worse

et al. 2011

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“…80 Park et al reported that resveratrol induces endoplasmic reticulum stress in HT 29 cells as seen from the upregulation of glucose-regulated protein (GRP)-78 and other markers of ER stress. 81 Resveratrol also induces CCAAT/ enhancer-binding protein-homologous protein (CHOP) in HT 29 cells 82 and inhibits the telomerase activity in HT-29 and WiDr cells. 83 Another report by Mohan et al suggested that resveratrol treatment activates caspase-2, which in turn triggers mitochondrial apoptotic events by inducing conformational changes in Bax/ Bak with subsequent release of cytochrome c, apoptosis-inducing factor and endonuclease G. 84 Resveratrol also produced growth inhibition and G 2 /M arrest in Caco-2 cells.…”

Section: Gastrointestinal and Colorectal Cancermentioning

confidence: 99%

Resveratrol: A multitargeted agent for age-associated chronic diseases

Harikumar¹,

Aggarwal²

2008

Cell Cycle

481

339

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Extensive research within the last decade has revealed that most chronic illnesses such as cancer, cardiovascular and pulmonary diseases, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. Thus mono-targeted therapies developed for the last two decades for these diseases have proven to be unsafe, ineffective and expensive. Although fruits and vegetables are regarded to have therapeutic potential against chronic illnesses, neither their active component nor the mechanism of action is well understood. Resveratrol (trans-3, 5, 4'-trihydroxystilbene), a component of grapes, berries, peanuts and other traditional medicines, is one such polyphenol that has been shown to mediate its effects through modulation of many different pathways. This stilbene has been shown to bind to numerous cell-signaling molecules such as multi drug resistance protein, topoisomerase II, aromatase, DNA polymerase, estrogen receptors, tubulin and F1-ATPase. Resveratrol has also been shown to activate various transcription factor (e.g., NFκB, STAT3, HIF-1α, β-catenin and PPAR-γ), suppress the expression of antiapoptotic gene products (e.g., Bcl-2, Bcl-X L , XIAP and survivin), inhibit protein kinases (e.g., src, PI3K, JNK and AKT), induce antioxidant enzymes (e.g., catalase, superoxide dismutase and hemoxygenase-1), suppress the expression of inflammatory biomarkers (e.g., TNF, COX-2, iNOS and CRP), inhibit the expression of angiogenic and metastatic gene products (e.g., MMPs, VEGF, cathepsin D and ICAM-1), and modulate cell cycle regulatory genes (e.g., p53, Rb, PTEN, cyclins and CDKs). Numerous animal studies have demonstrated that this polyphenol holds promise against numerous age-associated diseases including cancer, diabetes, Alzheimer, cardiovascular and pulmonary diseases. In view of these studies, resveratrol's prospects for use in the clinics are rapidly accelerating. Efforts are also underway to improve its activity in vivo through structural modification and reformulation. Our review describes various targets of resveratrol and their therapeutic potential.

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“…1,2 Resveratrol inhibits cancer cell growth in many cell lines, including cancers of the lung, prostate, colon, breast and ovaries. [3][4][5][6][7][8][9][10][11][12][13][14] Resveratrol also reduces tumor incidence in animal models by interfering with carcinogenesis through a wide array of anti-cancer actions. Several animal studies have demonstrated the ability of resveratrol to inhibit prostate cancer development by downregulating androgen receptors, inducing apoptosis/cell cycle arrest and inhibiting disease progression.…”

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confidence: 99%

Red wine consumption and risk of prostate cancer: The California Men's Health Study

Chao

Haque

Eeden

et al. 2009

Intl Journal of Cancer

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Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine intake on the risk of prostate cancer using data prospectively collected in the California Men's Health Study (CMHS). CMHS is a multiethnic cohort of 84,170 men aged 45-69 years who were members of the Kaiser Permanente Southern and Northern California Health Plans. Information on demographic and lifestyle factors was collected using mailed questionnaires between 2002 and 2003. We used Cox models to estimate the effect of red wine on prostate cancer risk, adjusting for potential confounders. A total of 1,340 incident prostate cancer cases identified from Surveillance, Epidemiology and End Result-affiliated cancer registries were included in the analyses. We did not find a clear association between red wine intake and risk of prostate cancer. Hazard ratio (HR) estimates for consuming <1 drink/week, 1 drink/week but <1 drink/day and 1 drink/day were 0.89, 95% confidence interval (0.74-1.07), 0.99 (0.83-1.17) and 0.88 (0.70-1.12), respectively. Further, we observed no linear dose response. The lack of association for red wine intake was consistently observed when we restricted the analyses to those with and without a history of PSA screening. In addition, we also did not observe any association with prostate cancer for beer, white wine, liquor or combined alcoholic beverage intake (HR for combined alcoholic beverage intake of 5 drinks/day 5 1.16 (0.83-1.63). Neither red wine nor total alcohol consumption were associated with prostate cancer risk in this population of moderate drinkers.Red wine is a rich source of polyphenol antioxidants such as resveratrol. Recently, resveratrol has received considerable attention because of its potent anti-cancer properties.

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Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

Cited by 55 publications

References 26 publications

Autophagy: for better or for worse

Autophagy: for better or for worse

Resveratrol: A multitargeted agent for age-associated chronic diseases

Red wine consumption and risk of prostate cancer: The California Men's Health Study

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