Red wine consumption and risk of prostate cancer: The California Men's Health Study

Abstract

Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine intake on the risk of prostate cancer using data prospectively collected in the California Men's Health Study (CMHS). CMHS is a multiethnic cohort of 84,170 men aged 45-69 years who were members of the Kaiser Permanente Southern and Northern California Health Plans. Information on demographic and lifestyle factors was collected using mailed questionnaires between 2002 and 2003. We used Cox models to estimate the effect of red wine on prostate cancer risk, adjusting for potential confounders. A total of 1,340 incident prostate cancer cases identified from Surveillance, Epidemiology and End Result-affiliated cancer registries were included in the analyses. We did not find a clear association between red wine intake and risk of prostate cancer. Hazard ratio (HR) estimates for consuming <1 drink/week, 1 drink/week but <1 drink/day and 1 drink/day were 0.89, 95% confidence interval (0.74-1.07), 0.99 (0.83-1.17) and 0.88 (0.70-1.12), respectively. Further, we observed no linear dose response. The lack of association for red wine intake was consistently observed when we restricted the analyses to those with and without a history of PSA screening. In addition, we also did not observe any association with prostate cancer for beer, white wine, liquor or combined alcoholic beverage intake (HR for combined alcoholic beverage intake of 5 drinks/day 5 1.16 (0.83-1.63). Neither red wine nor total alcohol consumption were associated with prostate cancer risk in this population of moderate drinkers.Red wine is a rich source of polyphenol antioxidants such as resveratrol. Recently, resveratrol has received considerable attention because of its potent anti-cancer properties.

Prostatitis, other genitourinary infections and prostate cancer: results from a population-based case–control study

“…Other advantages are: ability to control for other potential confounding factors, assessment of PCa risk according to Gleason grade and the population-based design. Our results are consistent with several studies, where history of prostatitis and its link with PCa were examined [3,8,20,21]. In the largest North American study, similar magnitude and same direction of the association were recorded [20].…”

“…Some of the previous studies showed an association between PCa and STIs [5,22], and others failed to find an association between those conditions [20,21,23]. A recently published review emphasized the fact that several publications found a decreased risk of PCa among users of anti-inflammatory agents (e.g., nonsteroidal antiinflammatory drugs) [24].…”

The association between prostatitis and prostate cancer. Systematic review and meta-analysis

“…These articles report the results of 15 case-control studies including a total population of 422.943 subjects. The Cheng 2010 and Chao 2010 articles (20,21) contained essential data from a single study (the California Men's health Study), whereas it was not sure whether the Rosenblatt 2001 study and the Rothman 2004 study focused on the same case and control populations (28,30). The sample size of our meta-analysis complied "optimal information size" criteria, as recommended by the GRADE guidelines (32, not shown).…”

Diet, Lifestyles, Family History, and Prostate Cancer Incidence in an East Algerian Patient Group

“…No current users were found in the population studied since cases and control individuals never drink alcohol or just drank a few times during their youth, with the rest (29% cases and 7% controls) being former users. Most studies showed no association between alcohol intake and PC [54–56] with a few studies reporting an inverse association [57, 58]. In a follow-up study of alcohol and PC, a significant inverse association was shown between distant past heavy drinking (25 drinks/week) and PC [58].…”