Elemental speciation by liquid chromatography–inductively coupled plasma mass spectrometry with direct injection nebulization

Shum, Sam C. K.; Neddersen, Robert; Houk, R. S.

doi:10.1039/an9921700577

Cited by 115 publications

(35 citation statements)

References 39 publications

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“…These observations are consistent with those made by Demesmay et al 10 who confirmed that at high concentrations of ethanol the plasma instability no longer allows a reproducible measurement and the carbon built-up on the sampler cone leads to progressive clogging of the interface and subsequently to a decrease of the signal over time. This is also consistent with Shum et al 11 . who studied the influence of the introduction of methanol with a specific sample introduction device.…”

Section: Results and Discussion Enhancing Sensitivitysupporting

confidence: 82%

Methodological Validation for the Determination of Toxic Arsenic Species in Human Urine Using HPLC With Icp-MS

Muñoz

Meneses

Pismante

et al. 2014

J. Chil. Chem. Soc.

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There is a significant amount of arsenic species in the environment and in biological systems; however, the toxicity and possibly the carcinogenicity of ingested arsenic depend on the species and the oxidation state. Therefore, analytical methodologies and techniques that are fast and robust, that involve highly efficient separation and are powerful tools of detection are necessary for the correct quantification of individual arsenic species. The field of speciation analysis of arsenic in this area has grown rapidly in recent years, especially with the application of liquid chromatography and mass spectrometry with inductively coupled plasma. This study aimed to develop and apply this technique to human urine samples in order to reduce the treatment needed for speciation, maintain maximum recovery and avoid interconversion and / or degradation between species. In order to optimize the separation of species, several experiments were performed by preparing the mobile phase at different pH values. The optimal pH value and the linearity of the method were determined and the methodology was validated using a Certified Reference Material. Student`s t-test and Fisher F-test for determination of accuracy and precision were applied. A simple, rapid and reliable method for the separation and quantification of several species of arsenic, As III (Arsenite), As V (Arsenate), MMA (Monomethyl Arsonic Acid), DMA (Dimethyl Arsinic Acid), AB (Arsenobetaine) was developed in human urine samples with minimal prior sample preparation. The time required for sample processing and isocratic chromatographic analysis is about 15 minutes. Detection limits of 0.020 µgL -1 of AsB, 0.020 µgL -1 of As III, 0.040 µgL -1 of DMA, 0.060 µgL -1 of MMA and 0.060 µgL -1 of As V were achieved under the analytical conditions mentioned above.

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Section: Results and Discussion Enhancing Sensitivitysupporting

confidence: 82%

Methodological Validation for the Determination of Toxic Arsenic Species in Human Urine Using HPLC With Icp-MS

Muñoz

Meneses

Pismante

et al. 2014

J. Chil. Chem. Soc.

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“…A plethora of methods exist for the detection of arsenic which include chemiluminescence [9], chromatography and spectroscopic [10,11]methods and various forms of ICP-MS [12,13]; for an overview of different methods see [14,15]. However the vast majority of these costly and sophisticated methods are suitable for laboratory based testing only.…”

Section: Introductionmentioning

confidence: 98%

Sonoelectroanalytical Detection of Ultra‐Trace Arsenic

2005

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The electroanalytical detection of arsenic on a gold electrode is investigated in the presence and absence of ultrasound. It is found that under quiescent conditions a detection limit of 1.8 Â 10 À7 M is achievable using a 120 seconds accumulation period. Applying optimised ultrasound during the accumulation period was found to reduce the limit of detection to 1 Â 10 À8 M from using a deposition period of 60 s at À 0.5 V, while increasing the sensitivity by a factor of 15. The methodology was tested on a river sample containing significant copper contamination and electrode passivating organic materials. This technique provides promise for in the field measurements due to the electrodedepassivating effects of ultrasound.

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“…Currently, DL = 0.1 µg/L in drinking water has become common (Guerin et al, 1999). Shum et al (1992) reached absolute DL lower than 1 pg, e.g. for 100 mL of sample, DL lower than 10 ng/L per species.…”

Section: Arsenic Speciation Hyphenated Techniquesmentioning

confidence: 99%

Arsenic Speciation Analysis in Water Samples: A Review of The Hyphenated Techniques

Terlecka

2005

Environ Monit Assess

106

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Interests in the determination of different arsenic species in natural waters is caused by the fact that toxic effects of arsenic are connected with its chemical forms and oxidation states. In determinations of water samples inorganic arsenate (As(III), As(V)), methylated metabolities (MMAA, DMAA) and other organic forms such as AsB, AsC, arsenosugars or arsenic containing lipids have the most importance. This article provides information about occurrence of the dominant arsenic forms in various water environments. The main factors controlling arsenic speciation in water are described. The quantification of species is difficult because the concentrations of different forms in water samples are relatively low compared to the detection limits of the available analytical techniques. Several hyphenated methods used in arsenic speciation analysis are described. Specific advantages and disadvantages of methods can define their application for a particular sample analysis. Insufficient selectivity and sensitivity of arsenic speciation methods cause searching for a new or modifications already existing techniques. Some aspects of improvement and modifications of the methods are highlighted.

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Elemental speciation by liquid chromatography–inductively coupled plasma mass spectrometry with direct injection nebulization

Cited by 115 publications

References 39 publications

Methodological Validation for the Determination of Toxic Arsenic Species in Human Urine Using HPLC With Icp-MS

Methodological Validation for the Determination of Toxic Arsenic Species in Human Urine Using HPLC With Icp-MS

Sonoelectroanalytical Detection of Ultra‐Trace Arsenic

Arsenic Speciation Analysis in Water Samples: A Review of The Hyphenated Techniques

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