Elemental profiling of adrenal adenomas in solid tissue and blood samples by ICP-MS and ICP-OES

Jagodić, Jovana; Rovčanin, Branislav; Krstić, Đurđa; Paunović, Ivan; Živaljević, Vladan; Manojlović, Dragan; Stojsavljević, Aleksandar

doi:10.1016/j.microc.2021.106194

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…The results of the present study have shown, for the first time, that there were statistically higher levels of essential Zn and Se and lower levels of Mn and Co in PCC tissue samples compared to HAT samples. Interestingly, our previous study regarding adenomatous adrenal tissue (AAT) had not singled out Co as significant in its discrimination from HAT [14]. Previously, a difference was measured in the level of Cu, which was significantly higher in AATs than that in HATs, contrary to the current research.…”

Section: Discussioncontrasting

confidence: 89%

“…Interesting findings in the levels of Pb and As have been observed. Both of these elements were statistically lower in PCC tissues compared to that in HATs, in contrast to AATs [14], wherein, among toxic elements, higher Pb was singled out. Sanders et al (2014) observed that Pb could contribute to oxidative stress, cytotoxicity, and genotoxicity in PC12 cells [27].…”

Section: Discussionmentioning

confidence: 68%

“…PCC tissues had higher levels of K, Mg, and Na compared to HATs, which is partially different from AATs, wherein K and Mg levels were statistically higher than that in HATs [14]. Sanders et al [27] observed the contribution of Mg to oxidative stress, cytotoxicity, and genotoxicity in PC12 cells.…”

Section: Discussionmentioning

confidence: 96%

“…5 The levels of statistically significantly different elements (ng/g) in the PCC tissue samples with tumor sizes above and below than 5 cm presented as mean and standard deviation and viability of PC12 cells [21], while its effect on the generation of reactive oxygen species (ROS) cannot be ruled out [22]. Elevated Zn levels were noted in both PCC tissues and AATs [14]. The toxic effect of elevated Zn on PC12 cells has been reported in several studies [23,24].…”

Section: Discussionmentioning

confidence: 98%

“…Samples of adrenal tissue and whole blood were prepared as previously described [14]. Briefly, samples were decomposed using microwave digestion (ETHOS 1, Milestone, Italy).…”

Section: Analysis Of Elementsmentioning

confidence: 99%

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Elemental Composition of Pheochromocytoma Resolved on Solid/Adrenal Tissue and Whole Blood Level

Jagodić

Rovčanin

Paunović

et al. 2021

Biol Trace Elem Res

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Pheochromocytoma (PCC) is an unusual benign adrenal tumor with an unexamined status of the elements. This study delivers the first insight into the levels of microelements (Mn, Co, Cu, Zn, As, Se, Th), toxic elements (Cd, Pb, U), and macroelements (Na, K, Mg, Ca) in both adrenal tissue and whole blood samples collected from PCC patients. The results were strengthened by comparing recorded findings with the patients' healthy adrenal tissue (HAT) and with whole blood samples from the healthy individuals. PCCs had significantly higher levels of Zn, Se, Na, K, and Mg and lower levels of Mn, Co, Pb, and As than that of HATs. Compared to healthy blood samples, the patients' blood exhibited considerably higher levels of Na, K, and Ca but significantly lower levels of Mn, Cu, Zn, Se, and Mg. Females had significantly higher levels of essential Se and toxic Pb and Cd in their PCC tissue samples compared to males. PCC tissue levels of Mn and Cu were significantly elevated in smokers over levels in nonsmokers and in PCC patients with tumor sizes below 5 cm compared to PCC diameters above 5 cm. The data presented in this study provide a new insight into the pathophysiology of PCC. Thus, recorded elements should be considered as initiators/modifiers of PCC and potential inductors of malignant transformation. The findings of this research deepen scientific understanding of this rare adrenal disease, which, in turn, could highlight the pathogenesis of PCC.

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

“…Samples of adrenal tissue and whole blood were prepared as previously described [14]. Briefly, samples were decomposed using microwave digestion (ETHOS 1, Milestone, Italy).…”

Section: Analysis Of Elementsmentioning

confidence: 99%

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