Elemental determination for clinical diagnosis and prognosis: Challenges and trends in sample preparation

Mesko, Márcia F.; Henn, Alessandra S.; Novo, Diogo La Rosa; Wilhelm, Ethel A.; Flores, Érico M.M.

doi:10.1016/bs.coac.2022.03.001

Cited by 2 publications

(2 citation statements)

References 99 publications

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“…The term bio element is used here as a common denominator name for major elements or electrolytes, trace bio elements and ultra-trace bio elements 2 . However, the great hopes for massive using of noninvasively collected hair for bio element analysis in clinical practice and epidemiological studies 3,4 faded when the analysis of the hair replicate samples yielded an excessive dispersion of the supposedly identical hair replicates samples 5 . It was assumed that the observed variability is related to the inaccuracies of chemical analysis of hair samples until Dinh and Wong 6 showed that what was considered to be the replicate of the hair sample was in fact a non-homogenous random mixture of hair piles in their various stages of hair developmental cycle.…”

Section: Introductionmentioning

confidence: 99%

Sex Dimorphism of Calcium and Magnesium Metabolism

Momčilović

2023

MRAJ

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Background. There is a need for assessing personalized nutritional status of the bio elements magnesium (Mg) and calcium (Ca). Objective. We studied the Mg and Ca nutritional status by analyzing their concentrations frequency distribution in the long-term biological indicator tissue of hair. Design. Hair Mg and Ca were analyzed in 1073 apparently healthy white adult Caucasians of both sexes [734 women (♀) and 339 men (♂)] with the ICP MS. The concentrate frequency distribution data were log transformed and the nutritional status assessed with the Median Derivatives Bioassay. Results. The hair median values (µg∙g-1) were Women (♀) Mg 254 and Men (♂) Mg 137.2 whereas W (♀) Ca median was 721.4 and M (♂) Ca 492.0, respectively. Adequate nutritional status range limits arranged themselves along the linear part of the sigmoid saturation curve. These linear adequate window range limits were for women magnesium W (♀) Mg 29.7–270.6 and for men M (♂) Mg 20.5–90.2. The adequate range limits for calcium were W (♀) Ca 487.7–4456.8 and M (♂) Ca 26.1–816.4. The bone seeking bio elements Ca, Mg, and Sr showed the same increasing affinity for women hair deposition, whereas the major cellular electrolytes of sodium and potassium were almost imperceptibly higher in men than women. Conclusions. Women hair incorporates Mg and Ca at about 2.5 times higher rate than men hair. The hair Median Derivatives Bioassay is a convenient painless way to assess and monitor the personalized dietary nutritional status of Mg and Ca in women and men.

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Section: Introductionmentioning

confidence: 99%

Sex Dimorphism of Calcium and Magnesium Metabolism

Momčilović

2023

MRAJ

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“…The concentration of Zn in a hair sample is about 100 times higher than in serum, and it is not as labile as serum concentration, which makes it perfect for long-term nutrition assessment [ 16 ]. In addition, the hair sample better reflects the recent excessive exposure to metals, as cations are quickly transferred from blood to tissue storage [ 17 , 18 ]. Hair samples are considered a good retrospective marker of microelement nutrition in the previous 6–8 weeks.…”

Section: Introductionmentioning

confidence: 99%

No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes

et al. 2022

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Although zinc (Zn) was reported to have antioxidant, anti-inflammatory and protective properties in CVDs, its association with coronary artery disease (CAD) is still unclear. As methods commonly used to assess Zn levels in blood and urine do not show the full picture of the microelement supply, in this study, the nutritional status of Zn in patients with angiographically confirmed CAD was assessed using inductively coupled plasma optical emission spectrometry. We found no association between Zn and the severity of CAD evaluated with the Coronary Artery Surgery Study Score (p = 0.67). There were no statistically significant differences in Zn levels between patients with acute coronary syndrome and those with stable CAD (p = 0.937). A statically significant negative correlation was observed between Zn content and serum triglyceride concentration (p < 0.05). Patients with type 2 diabetes mellitus were found to have a significantly lower hair Zn content compared to non-diabetic individuals (p < 0.01). The role of Zn in the pathogenesis of CAD and its complications need further well-designed research as the moderation and supplementation of Zn dietary intake could be a simple intervention to reduce the CVDs risk.

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Elemental determination for clinical diagnosis and prognosis: Challenges and trends in sample preparation

Cited by 2 publications

References 99 publications

Sex Dimorphism of Calcium and Magnesium Metabolism

Sex Dimorphism of Calcium and Magnesium Metabolism

No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes

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