Electrospun ZnO/Poly(Vinylidene Fluoride-Trifluoroethylene) Scaffolds for Lung Tissue Engineering

Azimi, Bahareh; Bafqi, Mohammad Sajad Sorayani; Fusco, Alessandra; Ricci, Claudio; Gallone, Giuseppe; Bagherzadeh, Roohollah; Donnarumma, Giovanna; Uddin, M. Jasim; Latifi, Masoud; Lazzeri, Andrea; Danti, Serena

doi:10.1089/ten.tea.2020.0172

Cited by 35 publications

(22 citation statements)

References 44 publications

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“…Surgical meshes and sutures require non-reactivity, whereas wound-healing applications require piezoelectricity [ 21 ]. Hence, this material is considered suitable for various biomedical applications such as tissue engineering [ 22 , 23 , 24 , 25 , 26 , 27 ], physiological signal detection [ 28 , 29 , 30 , 31 , 32 ], and antimicrobial and antifouling material development [ 22 , 33 , 34 , 35 , 36 , 37 , 38 ]. However, it is difficult to produce coatings for biomedical applications using PVDF because it does not form smooth films and exhibits issues in adhesion with other substrates.…”

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

“…Yin et al reviewed studies reporting the application of PVDF and its copolymer films using the spin coating and LB methods [ 39 ]. Several studies have reported that PVDF, along with other materials, form a composite or combination of materials that offer the advantages of both materials [ 22 , 23 , 24 , 28 , 29 , 31 , 33 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

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Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

Section: Biopolymer Coatings For Surface Modificationmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…In this regard, a recent review by Li et al highlighted the prospective application of electrospun PVDF and P(VDF-TrFE) scaffolds for the bone and neural tissue engineering [ 24 ]. Several studies have confirmed the tissue regeneration supporting properties of the electrospun scaffolds made of PVDF-based polymers for bone [ 25 ], muscle [ 26 ], cardiovascular [ 27 , 28 ], lung [ 29 ] and, more notably, nervous [ 30 , 31 ] tissue engineering applications. The PVDF-based materials were shown to improve the axonal regeneration for central nerve injuries and PNIs [ 30 ], the neurite outgrowth of sensory DRG neurons [ 32 , 33 ], and the neural differentiation of stem cells [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

PVDF and P(VDF-TrFE) Electrospun Scaffolds for Nerve Graft Engineering: A Comparative Study on Piezoelectric and Structural Properties, and In Vitro Biocompatibility

Gryshkov

Halabi

Kuhn

et al. 2021

IJMS

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Polyvinylidene fluoride (PVDF) and its copolymer with trifluoroethylene (P(VDF-TrFE)) are considered as promising biomaterials for supporting nerve regeneration because of their proven biocompatibility and piezoelectric properties that could stimulate cell ingrowth due to their electrical activity upon mechanical deformation. For the first time, this study reports on the comparative analysis of PVDF and P(VDF-TrFE) electrospun scaffolds in terms of structural and piezoelectric properties as well as their in vitro performance. A dynamic impact test machine was developed, validated, and utilised, to evaluate the generation of an electrical voltage upon the application of an impact load (varying load magnitude and frequency) onto the electrospun PVDF (15–20 wt%) and P(VDF-TrFE) (10–20 wt%) scaffolds. The cytotoxicity and in vitro performance of the scaffolds was evaluated with neonatal rat (nrSCs) and adult human Schwann cells (ahSCs). The neurite outgrowth behaviour from sensory rat dorsal root ganglion neurons cultured on the scaffolds was analysed qualitatively. The results showed (i) a significant increase of the β-phase content in the PVDF after electrospinning as well as a zeta potential similar to P(VDF-TrFE), (ii) a non-constant behaviour of the longitudinal piezoelectric strain constant d33, depending on the load and the load frequency, and (iii) biocompatibility with cultured Schwann cells and guiding properties for sensory neurite outgrowth. In summary, the electrospun PVDF-based scaffolds, representing piezoelectric activity, can be considered as promising materials for the development of artificial nerve conduits for the peripheral nerve injury repair.

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“…After 6 h, the ZnO in the composite scaffolds induced a strong anti-inflammatory response in A549 cells, as shown by a substantial decrease in IL-1, IL-6, and IL-8 production. TGF and the antimicrobial peptide HBD-2 were substantially increased in all scaffold types, but especially in aligned composite scaffolds [102].…”

Section: Regeneration Of Lung Tissue Using Biopolymeric Scaffoldsmentioning

confidence: 96%

The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

et al. 2021

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The lung is a vital organ that houses the alveoli, which is where gas exchange takes place. The COVID-19 illness attacks lung cells directly, creating significant inflammation and resulting in their inability to function. To return to the nature of their job, it may be essential to rejuvenate the afflicted lung cells. This is difficult because lung cells need a long time to rebuild and resume their function. Biopolymeric particles are the most effective means to transfer developing treatments to airway epithelial cells and then regenerate infected lung cells, which is one of the most significant symptoms connected with COVID-19. Delivering biocompatible and degradable natural biological materials, chemotherapeutic drugs, vaccines, proteins, antibodies, nucleic acids, and diagnostic agents are all examples of these molecules‘ usage. Furthermore, they are created by using several structural components, which allows them to effectively connect with these cells. We highlight their most recent uses in lung tissue regeneration in this review. These particles are classified into three groups: biopolymeric nanoparticles, biopolymeric stem cell materials, and biopolymeric scaffolds. The techniques and processes for regenerating lung tissue will be thoroughly explored.

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Electrospun ZnO/Poly(Vinylidene Fluoride-Trifluoroethylene) Scaffolds for Lung Tissue Engineering

Cited by 35 publications

References 44 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

PVDF and P(VDF-TrFE) Electrospun Scaffolds for Nerve Graft Engineering: A Comparative Study on Piezoelectric and Structural Properties, and In Vitro Biocompatibility

The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

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