Biopolymer Coatings for Biomedical Applications

Nathanael, A. Joseph; Oh, Tae Hwan

doi:10.3390/polym12123061

Cited by 79 publications

(48 citation statements)

References 102 publications

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“…It is a suitable antibiotic to be encapsulated in microfibers for antimicrobial activity and it could be utilized for wound healing applications as well [ 7 ]. For drug delivery applications, fibrous structures, including microfibers and nanofibers, are deemed acceptable carriers [ 8 , 9 ]. The microfibers are reported as an attractive option because of their flexible and soft nature.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers

et al. 2021

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Various systematic phases such as inflammation, tissue proliferation, and phases of remodeling characterize the process of wound healing. The natural matrix system is suggested to maintain and escalate these phases, and for that, microfibers were fabricated employing naturally occurring polymers (biopolymers) such as sodium alginate, gelatin and xanthan gum, and reinforcing material such as nanoclay was selected. The fabrication of fibers was executed with the aid of extrusion-gelation method. Rifampicin, an antibiotic, has been incorporated into a biopolymeric solution. RF1, RF2, RF3, RF4 and RF5 were coded as various formulation batches of microfibers. The microfibers were further characterized by different techniques such as SEM, DSC, XRD, and FTIR. Mechanical properties and physical evaluations such as entrapment efficiency, water uptake and in vitro release were also carried out to explain the comparative understanding of the formulation developed. The antimicrobial activity and whole blood clotting of fabricated fibers were additionally executed, hence they showed significant results, having excellent antimicrobial properties; they could be prominent carriers for wound healing applications.

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Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers

et al. 2021

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“…For this reason, with the aim of improving biomaterials performance, novel pathways to provide other beneficial properties, such as antibacterial [ 35 ], anti-inflammatory [ 36 ], drug delivery [ 37 ], self-healing [ 38 ] and tissue or wound healing [ 39 ] have been investigated for years. It is at this point in which reactive -OH groups of hydroxylated region acquire a crucial role because they provide reactivity to Ti surfaces for further chemical functionalization with active bio(macro)molecules, drugs, or other agents [ 40 , 41 ]. Therefore, surface activation processes apart from forming the beneficial oxide layer on Ti surfaces (TiO 2 ), allow us to obtain high hydroxylation (Ti-OH) degrees that enable a higher number of functionalization points with the active agents.…”

Section: Pre-activation Of Ti Surfacementioning

confidence: 99%

Bioactive Coatings on Titanium: A Review on Hydroxylation, Self-Assembled Monolayers (SAMs) and Surface Modification Strategies

et al. 2021

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Titanium (Ti) and its alloys have been demonstrated over the last decades to play an important role as inert materials in the field of orthopedic and dental implants. Nevertheless, with the widespread use of Ti, implant-associated rejection issues have arisen. To overcome these problems, antibacterial properties, fast and adequate osseointegration and long-term stability are essential features. Indeed, surface modification is currently presented as a versatile strategy for developing Ti coatings with all these challenging requirements and achieve a successful performance of the implant. Numerous approaches have been investigated to obtain stable and well-organized Ti coatings that promote the tailoring of surface chemical functionalization regardless of the geometry and shape of the implant. However, among all the approaches available in the literature to functionalize the Ti surface, a promising strategy is the combination of surface pre-activation treatments typically followed by the development of intermediate anchoring layers (self-assembled monolayers, SAMs) that serve as the supporting linkage of a final active layer. Therefore, this paper aims to review the latest approaches in the biomedical area to obtain bioactive coatings onto Ti surfaces with a special focus on (i) the most employed methods for Ti surface hydroxylation, (ii) SAMs-mediated active coatings development, and (iii) the latest advances in active agent immobilization and polymeric coatings for controlled release on Ti surfaces.

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“…The regeneration of adult tissue following an injury or degeneration is quite a limited process. Usually, the injury site is vulnerable to bacterial infections, which causes complications and delay of the regeneration of tissues [174]. Therefore, the prerequisite of tissue regeneration is to eliminate localized bacterial infections, followed by the delivery of bioactive molecules such as growth factor to the defected tissues.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents

Yin

Sun

2021

Pharmaceutics

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Bacterial infections have threatened the lives of human beings for thousands of years either as major diseases or complications. The elimination of bacterial infections has always occupied a pivotal position in our history. For a long period of time, people were devoted to finding natural antimicrobial agents such as antimicrobial peptides (AMPs), antibiotics and silver ions or synthetic active antimicrobial substances including antimicrobial peptoids, metal oxides and polymers to combat bacterial infections. However, with the emergence of multidrug resistance (MDR), bacterial infection has become one of the most urgent problems worldwide. The efficient delivery of antimicrobial agents to the site of infection precisely is a promising strategy for reducing bacterial resistance. Polymeric nanomaterials have been widely studied as carriers for constructing antimicrobial agent delivery systems and have shown advantages including high biocompatibility, sustained release, targeting and improved bioavailability. In this review, we will highlight recent advances in highly efficient delivery of antimicrobial agents by polymeric nanomaterials such as micelles, vesicles, dendrimers, nanogels, nanofibers and so forth. The biomedical applications of polymeric nanomaterial-based delivery systems in combating MDR bacteria, anti-biofilms, wound healing, tissue engineering and anticancer are demonstrated. Moreover, conclusions and future perspectives are also proposed.

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Biopolymer Coatings for Biomedical Applications

Cited by 79 publications

References 102 publications

Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers

Development and Evaluation of Rifampicin Loaded Alginate–Gelatin Biocomposite Microfibers

Bioactive Coatings on Titanium: A Review on Hydroxylation, Self-Assembled Monolayers (SAMs) and Surface Modification Strategies

Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents

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