The Potential Contribution of Biopolymeric Particles in Lung Tissue Regeneration of COVID-19 Patients

Abstract

The lung is a vital organ that houses the alveoli, which is where gas exchange takes place. The COVID-19 illness attacks lung cells directly, creating significant inflammation and resulting in their inability to function. To return to the nature of their job, it may be essential to rejuvenate the afflicted lung cells. This is difficult because lung cells need a long time to rebuild and resume their function. Biopolymeric particles are the most effective means to transfer developing treatments to airway epithelial cells and then regenerate infected lung cells, which is one of the most significant symptoms connected with COVID-19. Delivering biocompatible and degradable natural biological materials, chemotherapeutic drugs, vaccines, proteins, antibodies, nucleic acids, and diagnostic agents are all examples of these molecules‘ usage. Furthermore, they are created by using several structural components, which allows them to effectively connect with these cells. We highlight their most recent uses in lung tissue regeneration in this review. These particles are classified into three groups: biopolymeric nanoparticles, biopolymeric stem cell materials, and biopolymeric scaffolds. The techniques and processes for regenerating lung tissue will be thoroughly explored.

Tissue engineering application on coronavirus (Covid-19) Pandemic: A review

“…Using biopolymeric particles offers a promising method for delivering therapeutic agents directly to the damaged lung tissue of COVID-19 patients via catheter or aerosol, which can aid in the regeneration of lung tissue (36). Therefore, the entities mentioned are categorized as particles, including exosomes, microbubbles, and biopolymeric scaffolds.…”

“…Biomaterials like these can regenerate pulmonary tissue in individuals with severe respiratory conditions (8,39,40). Biopolymeric particles have been suggested as a feasible method to prevent the regeneration of lung tissue in COVID-19 patients (36). Nanomaterials have the potential to be used in creating scaffolds that mimic the structure and functions of organs affected by COVID-19.…”

“…COVID-19 patients are unlikely to benefit from the use of biomaterials in scaffold creation (41). Scaffolds have a unique ability to mimic the extracellular matrix of the tissue and can be customized to deliver therapeutic agents precisely to the wound site (36). It is highly unlikely for structures to be designed to facilitate the targeted and localized delivery of therapeutic substances to the exact site of an injury.…”

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

“…COVID-19 infection causes severe damage to the lower respiratory system by elucidating severe inflammatory response in the lungs which in some cases requires repairing of the damaged tissues. Moreover, the lack of oxygen in the patient's blood due to alveolar cell damage is a major concern that requires special attention to revive the damaged lung cells as soon as possible to restore normal alveolar function [204]. Preclinical studies on transplanting exogenous mesenchymal stem cells and their derived exosomes have proved their success in repairing damaged lung tissues and improving survival in animal models owing to their antiinflammatory and tissue regenerative activity [205][206][207].…”