Electrospun Polymers in Cartilage Engineering—State of Play

Yilmaz, Elif Nur; Zeugolis, Dimitrios I.

doi:10.3389/fbioe.2020.00077

Cited by 28 publications

(14 citation statements)

References 200 publications

(166 reference statements)

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“…The in vivo result in rabbit models confirmed that the scaffolds with patterned membranes manifested favorable biocompatibility and promoted tissue regeneration [201]. Besides trachea, electrospun fibers have been used as scaffolds for a wide range of tissue engineering applications including heart [202][203][204], bone [205][206][207], blood vessels [208][209][210], nerves [211][212][213], cartilage [214][215][216], etc. These fibers are usually combined with growth factors to regenerate lost or damaged tissues.…”

Section: Tissue Engineeringmentioning

confidence: 71%

Nanoengineered electrospun fibers and their biomedical applications: a review

et al. 2020

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Section: Tissue Engineeringmentioning

confidence: 71%

Nanoengineered electrospun fibers and their biomedical applications: a review

et al. 2020

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“…A promising approach is based on the possibility of obtaining structures similar to biological membranes, organs, and tissues [70] with the goal of using them as implants or in tissue engineering [71][72][73]. The method and the carrier are selected on the basis of the stability of biomaterial and its activity, including diffusion properties of the carrier.…”

Section: Encapsulation Of Cells and Microorganismsmentioning

confidence: 99%

Methods of Encapsulation of Biomacromolecules and Living Cells. Prospects of Using Metal–Organic Frameworks

et al. 2021

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The review discusses different methods of encapsulation and biomineralization of macromolecules and living cells. Main advantages and disadvantages of most commonly used carriers, matrices, and materials for immobilization of proteins, enzymes, nucleic acids, and living cells are briefly surveyed. Examples of delivery vehicles for multifunctional encapsulation of protein-like substances are presented. Particular attention is paid to prospects of using metal-organic frameworks in medicine and biotechnology.

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“…have been extensively studied in vivo for cartilage tissue engineering. [67,68] One strategy is to use the scaffold to deliver stem cells to the osteochondral defect in the animal model. Poly(caprolactone)polytetrahydrofuran (PCL-PTHF) complemented with collagen or chondroitin sulfate both induced the chondrogenesis of bone marrow-derived MSCs in vitro and in vivo and accelerated cartilage growth.…”

Section: Fibersmentioning

confidence: 99%

The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior

Wang

Hashemi

Stratton

et al. 2020

Adv Healthcare Materials

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Stem cells have been sought as a promising cell source in the tissue engineering field due to their proliferative capacity as well as differentiation potential. Biomaterials have been utilized to facilitate the delivery of stem cells in order to improve their engraftment and long-term viability upon implantation. Biomaterials also have been developed as scaffolds to promote stem cell induced tissue regeneration. This review focuses on the latter where the biomaterial scaffold is designed to provide physical cues to stem cells in order to promote their behavior for tissue formation. Recent work that explores the effect of scaffold physical properties, topography, mechanical properties and electrical properties, is discussed. Although still being elucidated, the biological mechanisms, including cell shape, focal adhesion distribution, and nuclear shape, are presented. This review also discusses emerging areas and challenges in clinical translation.

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Electrospun Polymers in Cartilage Engineering—State of Play

Cited by 28 publications

References 200 publications

Nanoengineered electrospun fibers and their biomedical applications: a review

Nanoengineered electrospun fibers and their biomedical applications: a review

Methods of Encapsulation of Biomacromolecules and Living Cells. Prospects of Using Metal–Organic Frameworks

The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior

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