Electrospun nanofibers for wound healing

Liu, Minghuan; Duan, Xidong; Li, Ye-Ming; Yang, Da‐Peng; Long, Yun-Ze

doi:10.1016/j.msec.2017.03.034

Cited by 389 publications

(220 citation statements)

References 121 publications

Supporting

Mentioning

210

Contrasting

Unclassified

Order By: Relevance

“…Numerous materials and processes have been proposed and applied for wound healing in soft tissues. Biomaterials produced by electrospinning method have been in the spotlight recently for soft tissue repair among the other applications due to the structural similarity of the nanosized polymer fibers to the natural ECM (James & Laurencin, 2016;Liu, Duan, Li, Yang, & Long, 2017). Their high surface area/volume ratio and high porosity make them superior to conventional biomaterials, in terms of cell adhesion and 3-D tissue ingrowth (Santos et al, 2010;Tuzlakoglu, Santos, Neves, & Reis, 2011).…”

Section: Discussionmentioning

confidence: 99%

Design of a new dual mesh with an absorbable nanofiber layer as a potential implant for abdominal hernia treatment

Kaya

Ahi

Ergene

et al. 2019

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Dual meshes are often preferred in the treatment of umbilical and incisional hernias where the abdominal wall defect is large. These meshes are generally composed of either two nonabsorbable layers or a nonabsorbable layer combined with an absorbable one that degrades within the body upon healing of the defect. The most crucial point in the design of a dual mesh is to produce the respective layers based on the structure and requirements of the recipient site. We herein developed a dual mesh that consists of two layers: a nanofibrous layer made of poly (glycerol sebacate)/poly (caprolactone) (PGS/PCL) to support the healing of the abdominal wall defect and a nondegradable, nonadhesive smooth layer made of polycarbonateurethane (PU) with suitable properties to avoid the adhesion of the viscera to the mesh. To prepare the double‐sided structure, PGS/PCL was directly electrospun onto the PU film. This processing approach provided a final product with well‐integrated layers as observed by a scanning electron microscope. Tensile test performed at the dry state of the samples showed that the dual mesh has the ability to elongate seven times more as compared with the commercially available counterparts, mimicking the native tissue properties. The degradation test carried out at physiological conditions revealed that PGS started to degrade within the first 15 days. in vitro studies with human umbilical vein endothelial cells demonstrated the double function of the meshes, in which PU layer did not allow cell adhesion, whereas PGS/PCL layer has the ability to support cell adhesion and proliferation. Therefore, the material developed in this study has the potential to be an alternative to the existing hernia mesh products.

show abstract

Section: Discussionmentioning

confidence: 99%

Design of a new dual mesh with an absorbable nanofiber layer as a potential implant for abdominal hernia treatment

Kaya

Ahi

Ergene

et al. 2019

J Tissue Eng Regen Med

View full text Add to dashboard Cite

show abstract

“…Polymeric fibers are characterized by increased surface area per volume compared to films. Furthermore, the nanofibrous matrix of the fibers mimics the ECM, providing a 3D scaffold for the migration of inflammatory cells . An increase in wound dressing porosity has been shown to facilitate more oxygen and moisture permeation .…”

Section: Exogenous Nitric Oxide For Chronic Wound Therapymentioning

confidence: 99%

“…An increase in wound dressing porosity has been shown to facilitate more oxygen and moisture permeation . It has also been reported that the hydration (i.e., water absorption) of electrospun fibers is 10–100 times greater than analogue film dressings . Drawbacks to using fibers as NO‐releasing wound dressings include potential undesirable leaching of the NO‐modified materials, hastened NO‐release kinetics due to increased water absorption, and a lower volume capacity, leading to decreased NO payloads …”

Section: Exogenous Nitric Oxide For Chronic Wound Therapymentioning

confidence: 99%

Nitric Oxide Therapy for Diabetic Wound Healing

Malone-Povolny

Maloney

Schoenfisch

2019

Adv Healthcare Materials

306

236

View full text Add to dashboard Cite

Nitric oxide (NO) represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Two broad strategies exist to utilize NO for wound healing; liberating NO from endogenous reservoirs, and supplementing NO from exogenous sources. This progress report examines the efficacy of a variety of NO‐based methods to improve wound outcomes, with particular attention given to diabetes‐associated chronic wounds.

show abstract

“…Generally, electrospun nanofibers could effectively carry both hydrophobic and hydrophilic drugs and achieve a sustained drug release profile, which enables them to serve as desired platform for biomedical applications, including wound dressing [9,10], anti-bacterial [11,12] and antitumor drug delivery [7,13,14]. However, conventional drugloaded nanofibers were simply prepared by directly doping drugs within polymer solutions before electrospinning to form the nanofibers, and always exhibit a burst drug release profile [15].…”

Section: Introductionmentioning

confidence: 99%

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

2019

View full text Add to dashboard Cite

Electrospun nanofibers hold a great potential in biomedical applications due to their advantages of large specific surface area, good biocompatibility, easy fabrication and surface modification. In particular, organic/inorganic hybrid nanofibers exhibit enhanced mechanical properties and long-term sustained release or controlled release profile of encapsulated drugs, which enables hybrid nanofibers to serve as desired platform for drug delivery and tissue engineering applications. This review summarizes the recent progresses in the preparation, performances and applications of hybrid nanofibers as drug delivery vectors for antibacterial and antitumor therapy, and as nanofibrous scaffolds for bone tissue engineering or other types of tissue engineering applications. Nanofibers doped with various types of inorganic nanoparticles (e.g., halloysite, laponite ® , nano-hydroxyapatite, attapulgite, carbon nanotubes, and graphene, etc.) are introduced and summarized in detail. Future perspectives are also briefly discussed. Graphic AbstractKeywords Electrospun nanofibers · Hybrid nanofibers · Drug delivery · Tissue engineering

show abstract

Electrospun nanofibers for wound healing

Cited by 389 publications

References 121 publications

Design of a new dual mesh with an absorbable nanofiber layer as a potential implant for abdominal hernia treatment

Design of a new dual mesh with an absorbable nanofiber layer as a potential implant for abdominal hernia treatment

Nitric Oxide Therapy for Diabetic Wound Healing

Construction of Electrospun Organic/Inorganic Hybrid Nanofibers for Drug Delivery and Tissue Engineering Applications

Contact Info

Product

Resources

About