Nitric Oxide Therapy for Diabetic Wound Healing

Malone-Povolny, Maggie J.; Maloney, Sara E.; Schoenfisch, Mark H.

doi:10.1002/adhm.201801210

Cited by 309 publications

(258 citation statements)

References 150 publications

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“…If inflammation is not controlled, it will lead to the self‐secretion of extracellular polysaccharide matrix, which will protect bacteria from the host's immune response and antibiotic therapy . In addition, persistent hyperglycemia would elevate the levels of advanced glycation end products (AGEs) in the blood, which can directly induce high concentration of ROS . This may disrupt the redox balance of the cells, causing metabolic disorders that further impair the structural integrity of the blood vessels and tissue regeneration …”

Section: Causes and Healing Of Woundsmentioning

confidence: 99%

“…In addition, persistent hyperglycemia would elevate the levels of advanced glycation end products (AGEs) in the blood, which can directly induce high concentration of ROS . This may disrupt the redox balance of the cells, causing metabolic disorders that further impair the structural integrity of the blood vessels and tissue regeneration …”

Section: Causes and Healing Of Woundsmentioning

confidence: 99%

“…Meanwhile, the expression of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) is also impaired . Then, the transformation from inflammation to proliferation of wounds is prevented, thus hindering the formation of new healthy tissues …”

Section: Causes and Healing Of Woundsmentioning

confidence: 99%

“…Clinically, chronic wounds usually refer to wounds caused by various reasons, which cannot automatically restore their functional integrity within three months, and also have no tendency to heal. [13][14][15] More seriously, due to the influence of potential physiological conditions, such as diabetes, chronic wounds not only heal slowly but are also often prone to recurrence. [32] The differences in the normal and diabetic wound healing phases can be seen from Figure 2.…”

Section: Causes and Hazards Of Chronic Woundsmentioning

confidence: 99%

“…[11][12][13] In chronic wounds, a sustained inflammatory response leads to a large accumulation of ROS, which exceeds the antioxidant capacity of the cells, thereby preventing the transition of the wound from the inflammatory phase to the proliferative phase. [14,15] It kept the wound site in a vicious circle of prolonged inflammation, thus eventually leading to chronic wound healing. Therefore, maintaining the balance of redox in cells, that is, to effectively achieve antioxidant, can hopefully avoid abnormal cell growth and disordered immune response.…”

Section: Introductionmentioning

confidence: 99%

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Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

437

305

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The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder of the wound microenvironment. Although numerous strategies and bioactive hydrogels are developed, an effective and widely used method of chronic wound treatment remains a bottleneck. With the aim to accelerate chronic wound healing, many hydrogel dressings with antioxidant functions have emerged and are proven to accelerate wound healing, especially for chronic wound repair. The new strategy in chronic wound treatment brought by antioxidant hydrogels is of great significance to human health. Here, the application of antioxidant hydrogels in the repair of chronic wounds is discussed systematically, aiming to provide an important theoretical reference for the further breakthrough of chronic wound healing.

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Section: Causes and Healing Of Woundsmentioning

confidence: 99%

Section: Causes and Healing Of Woundsmentioning

confidence: 99%

Section: Causes and Healing Of Woundsmentioning

confidence: 99%

Section: Causes and Hazards Of Chronic Woundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

437

305

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Insight into the Regulatory Function of Human Hair Keratins in Wound Healing Using Proteomics

Gao

Kan

et al. 2020

Adv. Biosys.

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Keratins derived from human hair possess excellent wound healing qualities. However, their functional contribution to this process is poorly understood. In this study, the regulatory function of human hair keratins in wound healing is investigated using proteomic analysis by dividing keratins into different groups based on their molecular weight distributions: low molecular weight keratins (LMWK, 10–30 kDa), medium molecular weight keratins (MMWK, 30–50 kDa), and high molecular weight keratins (HMWK, >50 kDa). Keratin hydrogels with different molecular weights exhibit various morphologies, rheological properties, degradation rates, and wound healing activities. Using proteomic analysis, LMWK and HMWK hydrogels exhibit a stronger regulatory ability for wound healing at days 1 and 7, respectively. The major functions of LMWK during wound healing are regulation of cells communication and function. In contrast, proteins associated with energy metabolism are significantly expressed after HMWK hydrogel treatment at day 1, and these play an important role in cellular growth and reactive oxygen species scavenging at day 7. These results demonstrate that the wound healing qualities of human hair keratins are influenced by their molecular weight distribution, and the proteomic analysis sheds new light on the regulatory function of human hair keratins during wound healing.

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Engineering Bioactive M2 Macrophage‐Polarized Anti‐Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair

Chen

Wang

et al. 2021

Adv Funct Materials

230

153

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Diabetic wound healing still faces great challenges due to the excessive inflammation, easy infection, and impaired angiogenesis in wound beds. The immunoregulation of macrophages polarization toward M2 phenotype that facilitates the transition from inflammation to proliferation phase has been proved to be an effective way to improve diabetic wound healing. Herein, an M2 phenotype-enabled anti-inflammatory, antioxidant, and antibacterial conductive hydrogel scaffolds (GDFE) for producing rapid angiogenesis and diabetic wound repair are reported. The GDFE scaffolds are fabricated facilely through the dynamic crosslinking between polypeptide and polydopamine and graphene oxide. The GDFE scaffolds possess thermosensitivity, self-healing behavior, injectability, broad-spectrum antibacterial activity, antioxidant and anti-inflammatory ability, and electronic conductivity. GDFE effectively activates the polarization of macrophages toward M2 phenotype and significantly promotes the proliferation of dermal fibroblasts, the migration, and in vitro angiogenesis of endothelial cells through paracrine mechanisms. The in vivo results from a full-thickness diabetic wound model demonstrate that GDFE can rapidly promote the diabetic wound repair and skin regeneration, through fast anti-inflammation and angiogenesis and M2 macrophage polarization. This study provides highly efficient strategy for treating diabetic wound repair through designing the M2 polarization-enabled anti-inflammatory, antioxidant, and antibacterial bioactive materials.

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Nitric Oxide Therapy for Diabetic Wound Healing

Cited by 309 publications

References 150 publications

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Insight into the Regulatory Function of Human Hair Keratins in Wound Healing Using Proteomics

Engineering Bioactive M2 Macrophage‐Polarized Anti‐Inflammatory, Antioxidant, and Antibacterial Scaffolds for Rapid Angiogenesis and Diabetic Wound Repair

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