Electrospun gelatin nanofibers loaded with vitamins A and E as antibacterial wound dressing materials

Li, Heyu; Wang, Maochun; Williams, Gareth R.; Wu, Junzi; Sun, Xiaozhu; Lv, Yao; Zhu, Li‐Min

doi:10.1039/c6ra05092a

Cited by 134 publications

(91 citation statements)

References 46 publications

(73 reference statements)

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“…Random and aligned fibers produced by electrospinning have been studied for different applications in the biomedical area, such as bone tissue engineering, vascular grafts, drug delivery, wound dressing, nerve regeneration, and so on. It is important to highlight that orientated fibers can influence cell adhesion, cell growth and modulate elongated cellular patterns that are typical of the morphology found in native tissues .…”

Section: Introductionmentioning

confidence: 99%

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Leal

Almeida

Dávila

et al. 2019

J of Applied Polymer Sci

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poly(L‐co‐D,L‐lactic acid) (PLDLA) is a bioresorbable and biocompatible copolymer obtained from the combination of L‐lactic and D, L‐lactic monomers. PLDLA membranes formed by aligned fibers were prepared by AC/DC electrospinning. Solutions of 8 and 10 wt % of PLDLA were used and membranes were collected by a rotating cylindrical collector. The results showed a slight increase in the fiber diameter with the increase in the polymer concentration. Fourier transform infrared spectroscopy results showed no changes in the chemical structure. Dynamic mechanical analysis results showed an increase in the storage modulus and a decrease in glass‐transition temperature for the 10 wt % samples, which was corroborated by differential scanning calorimetry. Thermogravimetric analysis showed a slight variation of the peak degradation temperature. Nevertheless, the samples did not present solvent residues. The membranes were tested in vitro using adipose‐derived mesenchymal stem cells (ASCs). The ASCs proliferated after 1, 7, and 14 days of culture, maintaining a spindle‐like morphology, which evidences their potential for tissue engineering applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47657.

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Section: Introductionmentioning

confidence: 99%

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Leal

Almeida

Dávila

et al. 2019

J of Applied Polymer Sci

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“…In addition to the possibility of using an electrospinning process to manufacture 3D scaffolds with tailorable fiber design (in terms of both diameter and distribution) as well as mechanical properties, other studies have considered the opportunity to use electrospun meshes as a vehicle to deliver bioactive factors (Hu et al, 2014;Sill & von Recum, 2008). Over the years, a number of drugs including antibiotics, anticancer drugs, as well as vitamins and proteins have been investigated as loading agents for the development of smart electrospun tissue engineering meshes, particularly for skin wound healing and bone tissue engineering applications (Huang, Branford-White, Shen, Yu, & Zhu, 2012;Li, Wang, Williams, et al, 2016;Lu, Jing, Song, & Wang, 2012;Sattary, Khorasani, Rafienia, & Rozve, 2018;Zahedi et al, 2012;Zhang et al, 2006).…”

Section: Electrospun Nanomaterials-based Meshesmentioning

confidence: 99%

The use of polymeric meshes for pelvic organ prolapse: Current concepts, challenges, and future perspectives

et al. 2019

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Pelvic organ prolapse (POP) is one of the most common chronic disorders in women, impacting the quality of life of millions of them worldwide. More than 100 surgical procedures have been developed over the decades to treat POP. However, the failure of conservative strategies and the number of patients with recurrence risk have increased the need for further adjuvant treatments. Since their introduction, surgical synthetic meshes have dramatically transformed POP repair showing superior anatomic outcomes in comparison to traditional approaches. Although significant progress has been attained, among the meshes in clinical use, there is no single mesh appropriate for every surgery. Furthermore, due to the risk of complications including acute and chronic infection, mesh shrinkage, and erosion of the tissue, the benefits of the use of meshes have recently been questioned. The aim of this work is to review the evolution of POP surgery, analyzing the current challenges, and detailing the key factors pertinent to the design of new mesh systems. Starting with a description of the pelvic floor anatomy, the article then presents the traditional treatments used in pelvic organ disorders. Next, the development of synthetic meshes is described with an insight into how their function is dependent on both mesh design variables (i.e., material, structure, and functional treatment) and surgical applications. These are then linked to common mesh‐related complications, and an indication of current research aiming to address these issues.

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“…To date, a variety of bioactive agents including antimicrobial agents, growth factors, genes, vitamins, metal, and metal oxide nanoparticles have been introduced into polymeric nanofibers for enhanced wound healing [12,21,22,26]. A recent study by Li et al [37] demonstrated the incorporation of vitamin A palmitate (VA) and vitamin E TPGS (VE), common derivatives of the unstable vitamins A and E into biodegradable GE nanofibers using electrospinning. The prepared nanofibers were studied for their sustained release behavior, antibacterial activity, cell proliferation, and in vivo wound healing performances.…”

Section: Natural Polymer Nanofibers As Wound Healing Scaffoldsmentioning

confidence: 99%

Electrospun nanofibrous materials for wound healing applications

Balusamy

Anitha

Uyar

2017

Electrospun Materials for Tissue Engineering and Biomedical Applications

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Electrospun gelatin nanofibers loaded with vitamins A and E as antibacterial wound dressing materials

Abstract: Illustration showing the fabrication process and test contents of electrospun gelatin nanofibers loaded with vitamins A and E as wound dressing materials in this paper.

Cited by 134 publications

References 46 publications

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

The use of polymeric meshes for pelvic organ prolapse: Current concepts, challenges, and future perspectives

Electrospun nanofibrous materials for wound healing applications

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