Characterization and in vitro evaluation of electrospun aligned‐fiber membranes of poly(L‐co‐D,L‐lactic acid)

Abstract

poly(L‐co‐D,L‐lactic acid) (PLDLA) is a bioresorbable and biocompatible copolymer obtained from the combination of L‐lactic and D, L‐lactic monomers. PLDLA membranes formed by aligned fibers were prepared by AC/DC electrospinning. Solutions of 8 and 10 wt % of PLDLA were used and membranes were collected by a rotating cylindrical collector. The results showed a slight increase in the fiber diameter with the increase in the polymer concentration. Fourier transform infrared spectroscopy results showed no changes in the chemical structure. Dynamic mechanical analysis results showed an increase in the storage modulus and a decrease in glass‐transition temperature for the 10 wt % samples, which was corroborated by differential scanning calorimetry. Thermogravimetric analysis showed a slight variation of the peak degradation temperature. Nevertheless, the samples did not present solvent residues. The membranes were tested in vitro using adipose‐derived mesenchymal stem cells (ASCs). The ASCs proliferated after 1, 7, and 14 days of culture, maintaining a spindle‐like morphology, which evidences their potential for tissue engineering applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47657.

Electrospun Membrane Based on Poly(L-co-D,L lactic acid) and Natural Rubber Containing Copaiba Oil Designed as a Dressing with Antimicrobial Properties

“…At 1081 cm −1 , the characteristic polylactide bands corresponding to the =C-O stretching can be observed. At 1181 cm −1 , there is a characteristic peak of the C-C bond [19]. The NR infrared spectrum presented bands of The PLDLA/NR infrared spectrum presented the main bands of both individual polymers (PLDLA and NR).…”

“…At 1081 cm −1 , the characteristic polylactide bands corresponding to the =C-O stretching can be observed. At 1181 cm −1 , there is a characteristic peak of the C-C bond [19]. The NR infrared spectrum presented bands of symmetrical and asymmetrical stretching of CH 2 and CH 3 groups between 2980 and 2850 cm −1 (2962, 2915 and 2850 cm −1 ).…”

“…The choice of these polymers is due to their inherent properties for application in the development of new biomaterials but considering, at first, the purposes a low-cost device and a material with easy degradability properties due to environmental approaches. In this way, the PLDLA (70/30) consists of an amorphous aliphatic polyester with the following biological properties: compatible, absorbable, and degradable [19]. On the other hand, the NR biopolymers from Hevea brasiliensis rubber trees are composed of long chains of poly(cis-1,4-isoprene), and due to such properties, they provide increased malleability and flexibility to the PLDLA due to its elastomeric features.…”

Quantitative characterization of dielectric properties of polymer fibers and polymer composites using electrostatic force microscopy

“…PLLA is the left-handed optical isomer of polylactide. PLLA is a biocompatible, biodegradable, and bioresorbable polymer [40,41,44,45]. PLLA has a very long degradation time profile in vivo and a high crystallinity of about 40%-50% depending on the annealing method [45,46].…”

Alternative Cutaneous Substitutes Based on Poly(l-co-d,l-lactic acid-co-trimethylene carbonate) with Schinus terebinthifolius Raddi Extract Designed for Skin Healing

“…One of them is the poly( l -lactic acid) and the other is poly( l - co - d , l -lactic acid) copolymer (PLDLA), which are semicrystalline and amorphous polymers, respectively. 9,10…”