Electrospun emodin polyvinylpyrrolidone blended nanofibrous membrane: a novel medicated biomaterial for drug delivery and accelerated wound healing

Abstract

In this work, blended nanofibrous membranes were prepared by an electrospinning technique with polyvinylpyrrolidone (PVP) K90 as the filament-forming polymer, and emodin, an extract of polygonum cuspidate known as a medicinal plant, as the treatment drug. Detailed analysis of the blended nanofibrous membrane by scanning electron microscopy, Differential scanning calorimetry and X-ray diffraction revealed that emodin was well distributed in the ultrafine fibers in the form of amorphous nanosolid dispersions. Results from attenuated total reflectance Fourier transform infrared spectra suggested that the main interactions between PVP and emodin might be mediated through hydrogen bonding. In vitro dissolution tests proved that the blended nanofibrous membrane produced more desired release kinetics of the entrapped drug (emodin) as compared to the pure drug. Furthermore, wound healing test and histological evaluation revealed that the emodin loaded nanofibrous membrane to be more effective as a healing accelerator thereby proving potential strategies to develop composite drug delivery system as well as promising materials for future therapeutic biomedical applications.

Correlation between Structures and Antioxidant Activities of Polyvinylpyrrolidone/Garcinia mangostana L. Extract Composite Nanofiber Mats Prepared Using Electrospinning

“…Such transition has also been obtained from the XRD studies of electrospun emodine/PVP nanofibers [34]. The presence of GME was found to alter the diffraction pattern of PVP.…”

“…Under this condition, GME can be dispersed in the PVP polymer matrix in molecular levels, not as dimers in crystal lattice. This is an advantageous feature of the electrospun PVP nanofibers as a drug delivery system, which can improve the stability of dispersed drug [34]. …”

Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis

“…Other than the anti-inflammatory effect of KET, the electrospun NF mats also protected the ulcer from bacterial infection where continuous re-epithelialization and shrinkage of the wound area in the treated group were observed, as a moist environment helped promote more rapid re-epithelialization. 61 …”

Multifunctional Nanofibers towards Active Biomedical Therapeutics

“…Drug loaded or non-loaded nanofibers showed a tendency to contract and dissolve under wet conditions. The test group showed better wound healing in comparision to the control group [137]. Electrospun fibers of poly(sulfobetaine methacrylate) were shown to have promising features for wound dressing material, but the fibers are super hydrophilic and tend to dissolve in water.…”