Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering

Zha, Fangwen; Chen, Wei; Hao, Lu; Wu, Chunsheng; Lu, Meng Chien; Zhang, Lifeng; Yu, Demei

doi:10.1039/d0sm00593b

Cited by 46 publications

(25 citation statements)

References 43 publications

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“…Electrospun fiber diameter, alignment, density, and surface nanotopography have all been shown to affect neuronal and glial behavior [24,[27][28][29]. Additionally, the unique properties of various materials used to generate electrospun fibers, such as biocompatibility, degradation rate, and conductivity ( Figure 1C), can affect cell adhesion, migration, and phenotype [30][31][32]. Fibers can also be further functionalized by incorporating drugs or surface coatings to produce a desirable effect for a given application [1,6,23,33] ( Figure 1D,E).…”

Section: Introductionmentioning

confidence: 99%

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

et al. 2020

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Electrospinning is a fabrication technique used to produce nano- or micro- diameter fibers to generate biocompatible, biodegradable scaffolds for tissue engineering applications. Electrospun fiber scaffolds are advantageous for neural regeneration because they mimic the structure of the nervous system extracellular matrix and provide contact guidance for regenerating axons. Glia are non-neuronal regulatory cells that maintain homeostasis in the healthy nervous system and regulate regeneration in the injured nervous system. Electrospun fiber scaffolds offer a wide range of characteristics, such as fiber alignment, diameter, surface nanotopography, and surface chemistry that can be engineered to achieve a desired glial cell response to injury. Further, electrospun fibers can be loaded with drugs, nucleic acids, or proteins to provide the local, sustained release of such therapeutics to alter glial cell phenotype to better support regeneration. This review provides the first comprehensive overview of how electrospun fiber alignment, diameter, surface nanotopography, surface functionalization, and therapeutic delivery affect Schwann cells in the peripheral nervous system and astrocytes, oligodendrocytes, and microglia in the central nervous system both in vitro and in vivo. The information presented can be used to design and optimize electrospun fiber scaffolds to target glial cell response to mitigate nervous system injury and improve regeneration.

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Section: Introductionmentioning

confidence: 99%

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

et al. 2020

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“…The biological response studies conducted using Schwann cells revealed improved cell attachment and higher proliferation following five days of incubation [126]. In another study, conductive polymers poly N-vinylpyrrole and poly(3-hexylthiophene) have been used with cellulose for the fabrication of conductive electrospun nanofibrous scaffold and demonstrated positive outcome [127]. In similar trend, many efforts have been devoted using carbon nanotubes [128], poly{[aniline tetramer methacrylamide]-co-[dopamine methacrylamide]-co-[poly(ethylene glycol) methyl ether methacrylate]} [129], and graphene [130].…”

Section: Nerve Tissue Engineeringmentioning

confidence: 99%

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

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E lektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır. Anahtar Kelimeler Elektro-eğirme, nanolif, yara örtüsü, doku mühendisliği.

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“…For nerve regeneration using electrospun textiles, conductive molecules were coelectrospun with polysaccharides or coated on polysaccharidic scaffolds to improve their conductivity for better performances. Zha et al [95] covered electrospun cellulose with poly N-vinylpyrrole and poly(3-hexylthiophene) through an efficient in situ polymerization, and they found increased thickness, porosity, conductivity, and hydrophilicity of the covered scaffolds. In vitro, undifferentiated PC12 cells showed favorable activity and adhesion to the scaffolds.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Electrospun Polysaccharidic Textiles for Biomedical Applications

Poshina

Otsuka

2021

Textiles

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Recent developments in electrospinning technology have enabled the commercial-scale production of nonwoven fabrics from synthetic and natural polymers. Since the early 2000s, polysaccharides and their derivatives have been recognized as promising raw materials for electrospinning, and their electrospun textiles have attracted increasing attention for their diverse potential applications. In particular, their biomedical applications have been spotlighted thanks to their “green” aspects, e.g., abundance in nature, biocompatibility, and biodegradability. This review focuses on three main research topics in the biomedical applications of electrospun polysaccharidic textiles: (i) delivery of therapeutic molecules, (ii) tissue engineering, and (iii) wound healing, and discusses recent progress and prospects.

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Electrospun cellulose-based conductive polymer nanofibrous mats: composite scaffolds and their influence on cell behavior with electrical stimulation for nerve tissue engineering

Abstract: Electrospun cellulose-based poly N-vinylpyrrole (PNVPY) and poly (3-hexylthiophene) (P3HT) nanofibrous mats and their influence on nerve cell behavior with electrical stimulation.

Cited by 46 publications

References 43 publications

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Electrospun Polysaccharidic Textiles for Biomedical Applications

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