Electrosprayed calcium silicate nanoparticle-coated titanium implant with improved antibacterial activity and osteogenesis

Buga, Csaba; Chen, Chuncheng; Hunyadi, M.; Csík, A.; Hegedűs, Csaba; Ding, Shinn-Jyh

doi:10.1016/j.colsurfb.2021.111699

Cited by 14 publications

(5 citation statements)

References 71 publications

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“…Bacteria-targeting nanomaterials have been widely used to treat bacterial, fungal, viral and parasitic infectious diseases in recent years [7][8][9][10][11][12][13][14], and their applications include direct bactericidal effects [15][16][17][18], encapsulation of probiotics [19], and encapsulation of bactericidal agents [20].…”

Section: The Development Of Organic Inorganic and Hybrid Nps For Infectious Diseasesmentioning

confidence: 99%

“…Inorganic nanomaterials with direct bactericidal effects include calcium silicate (CaSi) [15,21], silver (Ag) [22,23], copper (Cu) [24,25], and gold (Au) NPs [17,18]. Among the inorganic nanomaterials, Ag NPs have been one of the most widely used antimicrobial materials due to their broad-spectrum antibacterial capacity and low propensity to engender drug resistance [18].…”

Section: The Development Of Organic Inorganic and Hybrid Nps For Infectious Diseasesmentioning

confidence: 99%

“…Many NPs with bactericidal effects have been used to treat bone infection (such as osteomyelitis) or as part of the components of implants in the skeletal system [15,[129][130][131]. Bioactive nanostructured CaSi layers on titanium substrates constructed by electrospray deposition were shown to exert antibacterial effects against gram-negative E. coli and gram-positive S. aureus species, with additional osteogenic properties when coated on bone tissue [15]. Calcium-alginate (Ca-Alg) NPs crosslinked with phosphorylated polyallylamine (PPAA) and prepared by salting-out achieved 82.55% encapsulation of clindamycin, an antimicrobial agent for bone S. aureus infections [131].…”

Section: Skeletal System: Effective In Bone Regenerationmentioning

confidence: 99%

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Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

et al. 2021

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Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.

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Section: The Development Of Organic Inorganic and Hybrid Nps For Infectious Diseasesmentioning

confidence: 99%

Section: The Development Of Organic Inorganic and Hybrid Nps For Infectious Diseasesmentioning

confidence: 99%

Section: Skeletal System: Effective In Bone Regenerationmentioning

confidence: 99%

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Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

et al. 2021

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“…Various bioactive substances can be used as such materials. In particular, these include colloidal forms of metal silicates, as they have the necessary properties as well as good biological compatibility [ 18 , 19 , 20 , 21 , 22 ]. One can distinguish calcium silicate in the crystalline phase—wollastonite, due to its optimal physicochemical and antibacterial properties, as well as its ability to bind bone tissues [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Calcium Silicate Nanoparticles Stabilized with Amino Acids

et al. 2023

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This work presents the development of a method for the synthesis of calcium silicate nanoparticles stabilized with essential amino acids. CaSiO3 nanoparticles were obtained through chemical precipitation. In the first stage, the optimal calcium-containing precursor was determined. The samples were examined using scanning electron microscopy. It was found that Ca(CH3COO)2 was the optimal calcium-containing precursor. Then, the phase composition of calcium silicate was studied using X-ray phase analysis. The results showed the presence of high-intensity bands in the diffractogram, which characterized the phase of the nanosized CaSiO3—wollastonite. In the next stage, the influence of the type of amino acid on the microstructure of calcium silicate was studied. The amnio acids studied were valine, L-leucine, L-isoleucine, L-methionine, L-threonine, L-lysine, L-phenylalanine, and L-tryptophan. The analysis of the SEM micrographs showed that the addition of amino acids did not significantly affect the morphology of the CaSiO3 samples. The surface of the CaSiO3 samples, both without a stabilizer and with amino acids, was represented by irregularly shaped aggregates consisting of nanoparticles with a diameter of 50–400 nm. Further, in order to determine the optimal amino acid to use to stabilize nanoparticles, computerized quantum chemical modeling was carried out. Analysis of the data obtained showed that the most energetically favorable interaction was the CaSiO3–L-methionine configuration, where the interaction occurs through the amino group of the amino acid; the energy value of which was −2058.497 kcal/mol. To confirm the simulation results, the samples were examined using IR spectroscopy. An analysis of the results showed that the interaction of calcium silicate with L-methionine occurs via the formation of a bond through the NH3+ group of the amino acid.

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“…Large surface areas and tiny TiO 2 nanoparticles increase chemical reactivity, allowing them to penetrate living cells. Nanoparticles made of titanium dioxide (TiO 2 ) might penetrate human bodies and cause damage to organs such as the lung and brain [8]. TiO 2 nanoparticles might potentially harm cells such as HepG2, Raw 264.7, and HeLa.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of protein-coated titanium dioxide nanoparticles for cellular uptake fluorescence imaging and treatment of colorectal cancer

Zhang¹,

Wang²,

Yu³

2021

Mater. Res. Express

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We effectively fabricated Titanium dioxide nanoparticles that were protein-coated. Bovine serum albumin (BSA), lysozyme proteins, zein, and collagen have been used to coat titanium dioxide-aryl nanoparticles of the form TiO2-NPs. However, in both cases, no catalysts or other stabilising agents were used. These images of TiO2-NPs fabricated using the green method show high crystallinity. It is a malignant colorectal tumour with dysfunctional cellular processes that cause colorectal cancer cells. It is hoped that studies employing SW1417 cells would give mechanistic ideas on the specifics of the amplification in cancers. This was done by flow cytometry utilising and laser confocal fluorescence microscopy (LCFM) on the SW1417 colorectal cell line. Of the protein-coated Titanium dioxide nanoparticles fabricated green methods, BSA@TiO2-NPs were the most readily absorbed. Of all TiO2-NPs, lysozyme@TiO2-NPs fabricated by the chemical reduction technique were the most effectively internalised by SW1417 cells out of TiO2-NPs types.

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Electrosprayed calcium silicate nanoparticle-coated titanium implant with improved antibacterial activity and osteogenesis

Cited by 14 publications

References 71 publications

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases

Synthesis and Characterization of Calcium Silicate Nanoparticles Stabilized with Amino Acids

Fabrication of protein-coated titanium dioxide nanoparticles for cellular uptake fluorescence imaging and treatment of colorectal cancer

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