Electrospinning of Nanofibers from Polymer Solutions and Melts

Reneker, Darrell H.; Yarin, Alexander L.; Zussman, Eyal; Xu, Helan

doi:10.1016/s0065-2156(07)41002-x

Cited by 571 publications

(473 citation statements)

References 205 publications

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“…Electrospinning (ES) is considered to be the simplest technique to produce ultrafine fibers with average diameters of 10 nm to 10 μm from solution or melt (H. under the drawing force of the electrostatic field (Li and Xia, 2004;Reneker et al, 2007). Solventbased electrospinning has been found to be an excellent method also for the preparation of solid dispersions due to the fast and, thus, very efficient amorphization of the drug enclosed in the fibers owing a large surface area Yu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

Balogh

Farkas

Verreck

et al. 2016

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

Balogh

Farkas

Verreck

et al. 2016

International Journal of Pharmaceutics

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“…One of the attractive methods to fabricate artificial nano-and microscale polymeric fibers is by electrospinning. 3 This method is relatively simple, allowing for the manipulation of many parameters, such as fiber diameter and morphology, and enabling the formation of nonwoven mats with a controlled density. For these reasons, electrospinning has gained significant interest during the past decade as an alternative methodology for the development of biodegradable polymers for possible biomedical applications such as scaffolds for tissue engineering [4][5][6][7] and as carriers for drugs and bioactive molecules, including enzymes or even bacteria.…”

Section: Introductionmentioning

confidence: 99%

Nanofibers Made of Globular Proteins

et al. 2008

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Strong nanofibers composed entirely of a model globular protein, namely, bovine serum albumin (BSA), were produced by electrospinning directly from a BSA solution without the use of chemical cross-linkers. Control of the spinnability and the mechanical properties of the produced nanofibers was achieved by manipulating the protein conformation, protein aggregation, and intra/intermolecular disulfide bonds exchange. In this manner, a low-viscosity globular protein solution could be modified into a polymer-like spinnable solution and easily spun into fibers whose mechanical properties were as good as those of natural fibers made of fibrous protein. We demonstrate here that newly formed disulfide bonds (intra/intermolecular) have a dominant role in both the formation of the nanofibers and in providing them with superior mechanical properties. Our approach to engineer proteins into biocompatible fibrous structures may be used in a wide range of biomedical applications such as suturing, wound dressing, and wound closure.

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“…Blends of PNIPAM with such biocompatible and biodegradable polymers as Poly(acrylic acid) (PAA) can be easily prepared, which yield PAA polymer matrixes with PNIPAM islands inside. Electrospinning, co-electrospinning and various solution-precipitation methods allow for manufacturing of nanofibers and nanoparticles with embedded or grafted macromolecules [1][2][3][4][5]. In addition, nanofibers and nanoparticles functionalized with drugs attract significant interest in biomedical applications [6], where PNIPAM-like stimuli-responsive materials embedded in the bulk or grafted at the surface may facilitate efficient drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Responsive Polymers in Nanotechnology: Deposition and Possible Effect on Drug Release

Yarin

2008

Math. Model. Nat. Phenom.

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Abstract. Stimuli-responsive polymers result in on-demand regulation of properties and functioning of various nanoscale systems. In particular, they allow stimuli-responsive control of flow rates through membranes and nanofluidic devices with submicron channel sizes. They also allow regulation of drug release from nanoparticles and nanofibers in response to temperature or pH variation in the surrounding medium. In the present work two relevant mathematical models are introduced to address precipitation-driven deposition of surface layers of stimuli-responsive polymers and describe a possible effect of swelling-shrinkage transition of such polymers on drug release.

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Electrospinning of Nanofibers from Polymer Solutions and Melts

Cited by 571 publications

References 205 publications

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

Nanofibers Made of Globular Proteins

Stimuli-Responsive Polymers in Nanotechnology: Deposition and Possible Effect on Drug Release

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