Electrospinning and mechanical properties of polymeric fibers using a novel gap-spinning collector

Zernetsch, Holger; Repanas, Alexandros; Rittinghaus, Tim; Mueller, Marc; Alfred, Irene; Glasmacher, Birgit

doi:10.1007/s12221-016-6256-7

Cited by 15 publications

(13 citation statements)

References 25 publications

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“…We used an electrospinning device according to Fricke et al that consists of a drum collector, an electric motor, a blunt cannula, polyethylene tubing, a syringe and a syringe pump (see Supplementary Materials Figure S1 ) [ 9 , 11 , 12 , 13 ].…”

Section: Methodsmentioning

confidence: 99%

Mueller Matrix Analysis of Collagen and Gelatin Containing Samples Towards More Objective Skin Tissue Diagnostics

et al. 2020

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Electrospun polycaprolactone:gelatin (PCL:GT) fibre scaffolds are widely employed in the field of tissue implants. Here, the orientation of fibres plays an important role in regard to implantation due to the impact on the mechanical properties. Likewise, the orientation of collagen fibres in skin tissue is relevant for dermatology. State-of-the-art fibre orientation measurement methods like electron microscopy are time consuming and destructive. In this work, we demonstrate polarimetry as a non-invasive approach and evaluate its potential by measuring the Mueller matrix (MM) of gelatin and collagen containing samples as simple skin tissue phantoms. We demonstrate that it is possible to determine the orientation of PCL:GT fibre scaffolds within one MM measurement. Furthermore, we determine the structural orientation in collagen film samples. Currently, the diagnosis of skin diseases is often performed by image analysis or histopathology respectively, which are either subjective or invasive. The method presented, here, provides an interesting alternative approach for such investigations. Our findings indicate that the orientation of collagen fibres within skin lesions might be detectable by MM measurements in the future, which is of interest for skin diagnostics, and will be further investigated during the next step.

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Section: Methodsmentioning

confidence: 99%

Mueller Matrix Analysis of Collagen and Gelatin Containing Samples Towards More Objective Skin Tissue Diagnostics

et al. 2020

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“…Pure PCL and CS‐g‐PCL were processed to create a reference within this study. The electrospinning device consisted of a syringe holding the blends, an emitter connected by polyethylene tubing, and a collector covered with aluminum foil . Due to the need of aligned fibers for mechanical testing, samples for mechanical testing were produced using a drum collector with a rotational speed of 8 m/s.…”

Section: Methodsmentioning

confidence: 99%

Blending chitosan‐g‐poly(caprolactone) with poly(caprolactone) by electrospinning to produce functional fiber mats for tissue engineering applications

Cassan

Becker

Glasmacher

et al. 2019

J of Applied Polymer Sci

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Use of electrospun fiber mats for tissue engineering applications has become increasingly prominent. One of the most important polymers in research, poly(ε-caprolactone) (PCL), however, lacks biological performance, easy access to modifications and cellular recognition sites. To improve these properties and to enable further modifications, PCL was blended with chitosan grafted with PCL (CS-g-PCL) and subsequently processed via electrospinning. In this way, chitosan was enriched at the fiber's surface presenting cationic amino groups. The fiber mats were analyzed by various techniques such as scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and X-ray photoelectron spectroscopy (XPS). Furthermore, analyzing thermal properties and crystallinity, showed that an increased content of CS-g-PCL in blend composition leads to a higher overall crystallinity in produced fiber mats. Blending CS-g-PCL into PCL significantly increased initial cellular attachment and proliferation as well as cell vitality, while maintaining adequate mechanical properties, fiber diameter, and interstitial volume. As proof of principle for easy access to further modification, fluorescently labeled alginate (Alg-FA) was attached to the fiber's surface and verified by CLSM. Hence, blending CS-g-PCL with PCL can overcome an inherent weakness of PCL and create bioactive implants for tissue engineering applications.

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“…An algorithm was developed using Scilab software (Version 5.4.1, ESI Group, Rungis, France) to compute the data of the static testing and calculate ultimate tensile stress and elongation at break automatically [25]…”

Section: Mechanical Characterizationmentioning

confidence: 99%

Impact of sterilization by electron beam, gamma radiation and X-rays on electrospun poly-(ε-caprolactone) fiber mats

Cassan

Hoheisel

Glasmacher

et al. 2019

J Mater Sci: Mater Med

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Biodegradable polymers such as polycaprolactone (PCL) are increasingly used for electrospinning substrates for tissue engineering. These materials offer great advantages such as biocompatibility and good mechanical properties. However, in order to be approved for human implantation they have to be sterilized. The impact of commonly used irradiation sterilization methods on electrospun PCL fiber mats was investigated systematically. Electron beam (β-irradiation), gamma and X-ray irradiation with two different doses (25 and 33 kGy) were investigated. To determine the impact on the fiber mats, mechanical, chemical, thermal properties and crystallinity were investigated. Irradiation resulted in a significant decrease in molecular weight. At the same time, crystallinity of fiber mats increased significantly. However, the mechanical properties did not change significantly upon irradiation, mostly likely because effects of a lower molecular weight were balanced with the higher degree of crystallinity. The irradiation effects were dose dependent, a higher irradiation dose led to stronger changes. Gamma irradiation seemed to be the least suited method, while electron beams (β irradiation) had a lower impact. Therefore, β irradiation is recommended as sterilization method for electrospun PCL fiber mats.

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Electrospinning and mechanical properties of polymeric fibers using a novel gap-spinning collector

Cited by 15 publications

References 25 publications

Mueller Matrix Analysis of Collagen and Gelatin Containing Samples Towards More Objective Skin Tissue Diagnostics

Mueller Matrix Analysis of Collagen and Gelatin Containing Samples Towards More Objective Skin Tissue Diagnostics

Blending chitosan‐g‐poly(caprolactone) with poly(caprolactone) by electrospinning to produce functional fiber mats for tissue engineering applications

Impact of sterilization by electron beam, gamma radiation and X-rays on electrospun poly-(ε-caprolactone) fiber mats

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