Electrophysiological assessment of visual function in IDDM patients

Parisi, Vincenzo; Uccioli, Luigi; Monticone, Giovanna; Parisi, Luca; Manni, Gianluca; Ippoliti, Daniela; Menzinger, G.; Bucci, Massimo G.

doi:10.1016/s0168-5597(97)96606-5

Cited by 42 publications

(50 citation statements)

References 41 publications

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“…These timing delays in the retina could be compared with the conduction delays described elsewhere in the nervous system in diabetes. Several studies have described conduction delays in others electrophysiological tests in DM patients, such as prolonged peripheral nerve conduction velocities and visual evoked cortical potential latencies (Puvanendran et al 1983, Parisi et al 1997. This study showed similar results, once amplitude reduction and timing delays of all components of the ERG were observed and flicker's timing delays were statistically significant.…”

Section: Discussionsupporting

confidence: 82%

Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts

et al. 2010

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Being the commonest ocular disorder, dense cataracts disable fundoscopic examination and the diagnosis of retinal disorders, which dogs may be predisposed. The aim of this study was to compare the electroretinographic responses recorded according to the International Society for Clinical Electrophysiology of Vision human protocol to evaluate retinal function of diabetic and non diabetic dogs, both presenting mature or hypermature cataracts. Full-field electroretinogram was recorded from 66 dogs, with ages varying from 6 to 15 years old allocated into two groups: (1) CG, non diabetic cataractous dogs, and (2) DG, diabetic cataractous dogs. Mean peak-to-peak amplitude (microvolts) and b-wave implicit time (milliseconds) were determined for each of the five standard full-field ERG responses (rod response, maximal response, oscillatory potentials, single-flash cone response and 30 Hz flicker). Comparing CG to DG, ERGs recorded from diabetic dogs presented lower amplitude and prolonged b-wave implicit time in all ERG responses. Prolonged b-wave implicit time was statistically significant (p< 0.05) at 30 Hz flicker (24.0 ms versus 22.4 ms). These data suggests full-field ERG is capable to record sensible alterations, such as flicker's implicit time, being useful to investigate retinal dysfunction in diabetic dogs.

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Section: Discussionsupporting

confidence: 82%

Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts

et al. 2010

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“…An early involvement of the innermost retinal layers has been suggested. 26 Also, a delayed neural conduction in the post-retinal visual pathways has been found. The two sources might contribute independently to the abnormal VEP responses in the diabetics whereas another similar study shows that the increase in the P100 latency exhibited by diabetic patients with little or no retinopathy usually reflect altered retinal function rather than optic neuropathy.…”

Section: Discussionmentioning

confidence: 96%

Visual evoked potential changes in patients with diabetes mellitus without retinopathy

Gupta¹,

Gupta²,

Deshpande

2015

Int J Res Med Sci

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“…Moreover, several studies have used VEP to assess the visual pathway function and observed a delay in latency in patients with long-standing diabetes (Puvanendran 1983, Pozzessere et al 1991, Uberall et al 1996, Parisi et al 1997.…”

Section: Vep After Photostressmentioning

confidence: 99%

Visual evoked potentials in young persons with newly diagnosed diabetes: a long‐term follow‐up

Verrotti

Lobefalo

Trotta

et al. 2000

Develop Med Child Neuro

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To evaluate the presence of electrophysiological abnormalities in the visual function of young persons with diabetes, visual evoked potentials were recorded, in basal conditions and after photostress, in 30 patients with newly diagnosed insulin‐dependent diabetes mellitus. Their mean age was 17.6 years (3.6 SD), and their glycosated haemoglobin (HbA1c) was 9.4% (1.6 SD). Thirty healthy age‐ and sex‐matched individuals were evaluated as the control group. This study showed that the P100 latency was significantly delayed in patients with diabetes compared with the control group (p<0.01), while the N75 to P100 amplitude was similar in both groups. These measurements were repeated after 6 months, when all participants with diabetes had achieved good metabolic control (HbA1c 7.2% [1.5 SD]). At this second evaluation a complete normalisation of all parameters was observed. These findings suggest that early functional abnormalities of the optic nerve can be detected at onset of diabetes, and that glycaemic control reverses these abnormalities.

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Electrophysiological assessment of visual function in IDDM patients

Cited by 42 publications

References 41 publications

Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts

Comparison of full-field electroretinogram in diabetic and non diabetic dogs with cataracts

Visual evoked potential changes in patients with diabetes mellitus without retinopathy

Visual evoked potentials in young persons with newly diagnosed diabetes: a long‐term follow‐up

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