Electrophoretic deposition of chitosan-based composite coatings for biomedical applications: A review

Avcu, Egemen; Baştan, Fatih Erdem; Abdullah, Hasan Zuhudi; Rehman, Muhammad Atiq Ur; Avcu, Yasemin Yıldıran

doi:10.1016/j.pmatsci.2019.01.001

Cited by 252 publications

(197 citation statements)

References 320 publications

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“…The spectra of chitosan/curcumin and the PEEK/BG/h-BN layer are shown in Figure 8. The characteristic peaks of chitosan were found in the multilayer as well as in chitosan/curcumin single coatings; the carbonyl functional group (C-O) of chitosan was found at 1080 cm −1 [47,48,51]. The broad band at about 1022 cm −1 may have appeared because of the overlap of the C-O bond in chitosan and the bond corresponding to network modifiers in the glass structure [25,49,51].…”

Section: Ftir Analysismentioning

confidence: 99%

“…The characteristic peaks of chitosan were found in the multilayer as well as in chitosan/curcumin single coatings; the carbonyl functional group (C-O) of chitosan was found at 1080 cm −1 [47,48,51]. The broad band at about 1022 cm −1 may have appeared because of the overlap of the C-O bond in chitosan and the bond corresponding to network modifiers in the glass structure [25,49,51]. Furthermore, the peak found at 1408 cm -1 is assigned to the asymmetrical bending in C-H, and the peak at about 1570 cm −1 is attributed to N-H bonding vibration of chitosan [52,53].…”

Section: Ftir Analysismentioning

confidence: 99%

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Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

et al. 2019

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Electrophoretic deposition (EPD) was used to produce a multilayer coatings system based on chitosan/curcumin coatings on poly-ether-ether-ketone (PEEK)/bioactive glass (BG)/hexagonal boron nitride (h-BN) layers (previously deposited by EPD on 316L stainless steel) to yield bioactive and antibacterial coatings intended for orthopedic implants. Initially, PEEK/BG/h-BN coatings developed on 316L stainless steel (SS) substrates were analyzed for wear studies. Then, the EPD of chitosan/curcumin was optimized on 316L SS for suspension stability, thickness, and homogeneity of the coatings. Subsequently, the optimized EPD parameters were applied to produce chitosan/curcumin coatings on the PEEK/BG/h-BN layers. The multilayered coatings produced by EPD were characterized in terms of composition, microstructure, drug release kinetics, antibacterial activity, and in vitro bioactivity. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) confirmed the deposition of chitosan/curcumin on the multilayer coating system. The release of curcumin upon immersion of multilayer coatings in phosphate-buffered saline (PBS) was confirmed by ultraviolet/visible (UV/VIS) spectroscopic analysis. The antibacterial effect of chitosan/curcumin as the top coating was determined by turbidity tests (optical density measurements). Moreover, the multilayer coating system formed an apatite-like layer upon immersion in simulated body fluid (SBF), which is similar in composition to the hydroxyapatite component of bone, confirming the possibility of achieving close bonding between bone and the coating surface.

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Section: Ftir Analysismentioning

confidence: 99%

Section: Ftir Analysismentioning

confidence: 99%

Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

et al. 2019

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“…Electrophoretic deposition (EPD) is a widely adopted method for the deposition of biopolymers and organic and inorganic coatings on metallic substrates due to its effectiveness and versatility [22]. During EPD, charged particles or molecules move in a liquid medium and deposit on the electrode (e.g., a metallic substrate) under the application of an electric field [23].…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Akhtar

Ilyas

Dlouhý

et al. 2020

IJMS

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Bacterial infection associated with medical implants is a major threat to healthcare. This work reports the fabrication of Copper(II)–Chitosan (Cu(II)–CS) complex coatings deposited by electrophoretic deposition (EPD) as potential antibacterial candidate to combat microorganisms to reduce implant related infections. The successful deposition of Cu(II)–CS complex coatings on stainless steel was confirmed by physicochemical characterizations. Morphological and elemental analyses by scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) spectroscopy verified the uniform distribution of copper in the Chitosan (CS) matrix. Moreover, homogeneous coatings without precipitation of metallic copper were confirmed by X-ray diffraction (XRD) spectroscopy and SEM micrographs. Controlled swelling behavior depicted the chelation of copper with polysaccharide chains that is key to the stability of Cu(II)–CS coatings. All investigated systems exhibited stable degradation rate in phosphate buffered saline (PBS)–lysozyme solution within seven days of incubation. The coatings presented higher mechanical properties with the increase in Cu(II) concentration. The crack-free coatings showed mildly hydrophobic behavior. Antibacterial assays were performed using both Gram-positive and Gram-negative bacteria. Outstanding antibacterial properties of the coatings were confirmed. After 24 h of incubation, cell studies of coatings confirms that up to a certain threshold concentration of Cu(II) were not cytotoxic to human osteoblast-like cells. Overall, our results show that uniform and homogeneous Cu(II)–CS coatings with good antibacterial and enhanced mechanical stability could be successfully deposited by EPD. Such antibiotic-free antibacterial coatings are potential candidates for biomedical implants.

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“…Over the last decade, the electrophoretic deposition (EPD) technique has been extensively utilized for the ceramic coatings in various fields, including energy and medical engineering (Avcu et al, ; Horandghadim, Khalil‐Allafi, & Urgen, ; Zargazi & Entezari, ). The low cost, simplicity of the process, and the high quality of the EPD coating have expedited its commercialization for applying ceramic coatings on metal substrates (Besra & Meilin, ; Boccaccini, Keim, Ma, Li, & Zhitomirsky, ).…”

Section: Introductionmentioning

confidence: 99%

Structural characterization, mechanical, and electrochemical studies of hydroxyapatite‐titanium composite coating fabricated using electrophoretic deposition and reaction bonding process

et al. 2019

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In the present work, hydroxyapatite (HA)-titanium (Ti, 20 wt%) composite coating was coated on NiTi alloy substrate by EPD (electrophoretic deposition) process.Before applying the coating, the HA powder was composed with Ti powder using a ball milling process. Influence of the ball milling time on morphology and phase structure of HA-Ti powder was evaluated using TEM and XRD analysis. After composing the HA particles with Ti, the HA-Ti composite powders were coated on the NiTi substrate by the EPD process in an n-butanol medium for 2 min, with the applied voltage of 60 V. XRD and SEM analysis were utilized to evaluate the phase analysis and morphology of the coatings. Mechanical and electrochemical characteristic of the coatings were also assessed using the micro-indentation, micro-scratch, and polarization tests, respectively. The results revealed that the milling process time had a significant influence on reaction bonds and optimum mixing time was 4 hr. Micro-hardness of the HA-Ti composite coating (304 HV) was substantially higher than the HA coating (72 HV). Also, as the HA coating was composed with Ti particles, the amount of force (in the micro-scratch test) required for detaching the coating from the NiTi substrate increased from 7.1 to 17.8 N. The polarization results showed that the HA-Ti composite coating had a higher electrochemical resistance compared with the HA coating. Corrosion resistance of the NiTi alloy coated with HA increased from 133 kΩ. cm 2 to 2,720 kΩ.cm 2 after composed with the Ti particles.

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Electrophoretic deposition of chitosan-based composite coatings for biomedical applications: A review

Cited by 252 publications

References 320 publications

Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

Curcumin-Containing Orthopedic Implant Coatings Deposited on Poly-Ether-Ether-Ketone/Bioactive Glass/Hexagonal Boron Nitride Layers by Electrophoretic Deposition

Electrophoretic Deposition of Copper(II)–Chitosan Complexes for Antibacterial Coatings

Structural characterization, mechanical, and electrochemical studies of hydroxyapatite‐titanium composite coating fabricated using electrophoretic deposition and reaction bonding process

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