Electrooxidation Behavior and Amperometric Determination of Sotalol on a Graphene Oxide Nanosheets-modified Glassy Carbon Electrode

Heli, H.; Zare, S. N.; Sattarahmady, N.; Karimian, Khashayar

doi:10.2174/1573412911309030007

Cited by 11 publications

(9 citation statements)

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“…Graphene oxide nanosheets were synthesized using the previously reported method 22,32,34 based on a modied Hummers method. 44 In a typical procedure, graphite powder (2.0 g) was dispersed in concentrated sulfuric acid (140 mL), and sodium nitrate (1.0 g) was added to the reaction mixture in an ice bath.…”

Section: Methodsmentioning

confidence: 99%

“…Nanostructured materials represent excellent electronic and ionic conductivity, catalytic and electrocatalytic activity, and redox behavior, which cause the acceleration of direct or mediated electron transfer rate between the electrode surface and redox species. [3][4][5][22][23][24][25] Voltammetric and amperometric sensors and biosensors fabricated by these materials have many applications in the development of drug analysis techniques in various pharmaceutical forms and biological uids. 4,5,[25][26][27][28] Among the nanomaterials, carbon nanostructure-based sensors and biosensors exhibit unique sensing utility and gures of merit.…”

Section: Introductionmentioning

confidence: 99%

“…4,5,[25][26][27][28] Among the nanomaterials, carbon nanostructure-based sensors and biosensors exhibit unique sensing utility and gures of merit. [29][30][31] In this regard, graphene has attracted attention for the construction of electrochemical devices, 22,[32][33][34] and has been applied in the electroanalysis of dopamine, ascorbic acid and uric acid, 35,36 cadmium and lead, 37,38 glucose, 39 some drugs, 22,40,41 and cancer markers. 42,43 In the present study, the electrochemical behavior of perphenazine was rst investigated on a graphene oxide nanosheet-modied electrode in phosphate buffer solution at pH 7.4.…”

Section: Introductionmentioning

confidence: 99%

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Electrooxidation and determination of perphenazine on a graphene oxide nanosheet-modified electrode

2015

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The electrochemical behavior of perphenazine was investigated on a graphene oxide nanosheet-modified glassy carbon electrode in a phosphate buffer solution at pH 7.4. Cyclic voltammetry was employed to study the drug electrooxidation process. Perphenazine was electrooxidized on the modified electrode surface at lower potentials with a higher rate through an irreversible process. The kinetic parameters of the electrooxidation reaction, including the standard rate constant as well as diffusion and charge transfer coefficients were obtained. Amperometric and differential pulse voltammetric procedures were developed for the determination of perphenazine. Linear dynamic ranges of 0.8-8.0 and 0.7-7.0 mmol L À1 with calibration sensitivities of 35.23 and 36.54 mA mol À1 L cm À2 and detection limits of 46.6 and 38.4 mmol L À1 were obtained using amperometry and differential pulse voltammetry, respectively.The amperometric method was applied in the analysis of perphenazine tablets, and the applicability of the method for the direct assays of spiked human serum, urine and breast milk fluids was investigated.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electrooxidation and determination of perphenazine on a graphene oxide nanosheet-modified electrode

2015

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“…SOT is almost completely absorbed after oral administration and is excreted almost entirely in urine as an unchanged drug with 50 to 80 % of a dose being excreted in 24 hrs; less than 10 % is eliminated in the faeces . SOT has been quantified using several different analytical methodologies including: chromatography , fluorescence , capillary zone electrophoresis , and electrochemical (voltammetry) .…”

Section: Introductionmentioning

confidence: 99%

Incorporation of Tetrazolium Blue (TB)/Gold Nanoparticles (GNPs) into Carbon Paste Electrode: Application as an Electrochemical Sensor for the Sensitive and Selective Determination of Sotalol in Micellar Medium

et al. 2017

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The electrochemical oxidation of Sotalol (SOT) based on Tetrazolium Blue (TB)/gold nanoparticles (GNPs)‐modified carbon paste electrodes (CPE) have been studied in the presence of sodium lauryl sulphate (SLS). Cyclic voltammetry (CV), differential pulse voltammetry (DPV), chronoamperometry and electrochemical impedance spectroscopy (EIS) techniques have all been utilized within this study. GNPs and TB have a synergetic effect‐giving rise to highly improved electrochemical responses and provide an advantageous platform for the basis of an electrochemical sensor with excellent performance. The experimental parameters, electrodeposition time, pH and scan rate have all been examined and optimized. The sensing of SOT via DPV is found to exhibit a wide linear dynamic range of 1.0×10−7–7.5×10−4 M in pH 2. LOD and LOQ were calculated and found to correspond to 2.5×10−8 M and 8.3×10−8 M, respectively. The suggested sensor has been used successfully for SOT determination in pharmaceutical samples and human urine as real samples. Satisfactory recoveries of analyte from these samples are demonstrated indicating that the suggested sensor is highly suitable for clinical analysis, quality control and a routine determination of SOT in pharmaceutical formulations.

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“…Nanostructured materials have great applications in electrochemical sensing and biosensing and in this regard, many types of nanostructures including carbon allotropes, metals, metal oxides and metal complexes have been employed. [1][2][3][4][5][6] These nanomaterials represent excellent electronic conductivity and electrocatalytic properties that cause acceleration of the electron transfer rate between the electrode surface and redox species. [1][2][3][4][5][6][7] Chemically modied electrodes are intensively interesting in the studies of direct and mediated electron transfer processes, membrane barriers, electroorganic synthesis, and electroanalysis of biologically active compounds.…”

Section: Introductionmentioning

confidence: 99%

Electrocatalytic oxidation and electrochemical detection of guanine,l-arginine andl-lysine at a copper nanoparticles-modified electrode

2014

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Electrooxidation Behavior and Amperometric Determination of Sotalol on a Graphene Oxide Nanosheets-modified Glassy Carbon Electrode

Cited by 11 publications

References 0 publications

Electrooxidation and determination of perphenazine on a graphene oxide nanosheet-modified electrode

Electrooxidation and determination of perphenazine on a graphene oxide nanosheet-modified electrode

Incorporation of Tetrazolium Blue (TB)/Gold Nanoparticles (GNPs) into Carbon Paste Electrode: Application as an Electrochemical Sensor for the Sensitive and Selective Determination of Sotalol in Micellar Medium

Electrocatalytic oxidation and electrochemical detection of guanine,l-arginine andl-lysine at a copper nanoparticles-modified electrode

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