Electroosmotic transport of mannitol across human nail during constant current iontophoresis

Dutet, Julie; Delgado‐Charro, M. Begoña

doi:10.1211/jpp.62.06.0008

Cited by 17 publications

(2 citation statements)

References 24 publications

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“…Chemical enhancers such as urea, thioglycolic acid, hydrophobins, 2‐mercaptoethanol, N‐acetyl‐L‐cysteine, keratolytic agents and surfactants have shown some promising results in enhancing nail permeability. Other physical methods such as iontophoresis, nail abrasion, acid etching and nail micro‐drilling also enhance the permeability of the nail plate. Combination of one or more of the above mentioned methods has been reported to yield permeability enhancement synergistically …”

Section: Permeability Of Human Nail Platementioning

confidence: 99%

Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases

Baswan

Kasting

et al. 2017

Mycoses

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The topical treatment of nail fungal infections has been a focal point of nail research in the past few decades as it offers a much safer and focused alternative to conventional oral therapy. Although the current focus remains on exploring the ways of enhancing permeation through the formidable nail barrier, the understanding of the nail microstructure and composition is far from complete. This article reviews our current understanding of the nail microstructure, composition and diseases. A few of the parameters affecting the nail permeability and potential causes of the recurrence of fungal nail infection are also discussed.

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Section: Permeability Of Human Nail Platementioning

confidence: 99%

Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases

Baswan

Kasting

et al. 2017

Mycoses

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“…It is usually in the same direction as flow of counter ions. This mechanism may assist or hinder drug transport 61 . Due to electro, osmotic flow the transport of large anion from anodic compartment is beneficial than cathodic compartment.…”

Section: Fig 3: Iontophoresis Pathway Of Drug Penetrationmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:The skin has been used as a medium for systemic delivery of therapeutic agents. The resistance provided by the stratum corneum is the major barrier in delivering of the agents through skin. Due to this the number of drug molecules used under this category is limited. Iontophoresis is an efficient technique for physically enhancing conveyance of molecules across skin for local and systemic effects. The main feature offered by iontophoresis is the control offered by it in dose modulation by adjustment of current applied to undergo the process. It is suitable as an alternative for parenteral route as it is pain free and cost effective technique. The flux associated with iontophoretic treatment is described along with its applications in the article. The future aspects of iontophoretic treatment and the medications currently available are included in this article. Iontophoresis as a treatment regimen has gained popularity in relatively less treatment methodology but the concept should be well popularized as it offers enhancement to transdermal drug delivery system. This system being non invasive, pain free and with minimum side effects must be made use of in most of the treatment regimen.

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Science of the Nail Apparatus

Berker

Baran

2012

Baran &Amp; Dawber's Diseases of the Nails and Their Management

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Electroosmotic transport of mannitol across human nail during constant current iontophoresis

Abstract: These results suggest a modest and highly variable contribution of electroosmosis to the iontophoretic transungual flux.

Cited by 17 publications

References 24 publications

Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases

Understanding the formidable nail barrier: A review of the nail microstructure, composition and diseases

Untitled

Science of the Nail Apparatus

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