“…Chemical enhancers such as urea, thioglycolic acid, hydrophobins, 2‐mercaptoethanol, N‐acetyl‐L‐cysteine, keratolytic agents and surfactants have shown some promising results in enhancing nail permeability. Other physical methods such as iontophoresis, nail abrasion, acid etching and nail micro‐drilling also enhance the permeability of the nail plate. Combination of one or more of the above mentioned methods has been reported to yield permeability enhancement synergistically …”