Electronic and steric control over Au⋯Au, C–H⋯O and C–H⋯π interactions in the crystal structures of mononuclear triarylphosphinegold(i) carbonimidothioates: R3PAu[SC(OMe)=NR′] for R = Ph, o-tol, m-tol or p-tol, and R′ = Ph, o-tol, m-tol, p-tol or C6H4NO2-4

Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC6H4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination

“…The powder X-ray diffraction patterns recorded on the bulk materials were consistent with the simulated patterns calculated from their single-crystal X-ray data (see Supplementary material Fig. S1), which demonstrated linear P-Au-S coordination geometries [23,25,26]. The UV/Vis absorption spectra revealed a single band at 242 nm, and when excited at this wavelength in the photoluminescence experiments, three absorptions were observed at 342.5, 422.5 and 487.5 nm as detailed in Supplementary material Table S2 and Figs S2 and S3.…”

Supra-molecular synthons based on gold…π(arene) interactions

“…Thus, the addition of highly electronegative nitro groups to the thiolate-arene ring in the tolyl-phosphane derivative, (p-tol) 3 PAu[SC(OMe)=NC 6 H 4 NO 2 -p], was sufficient to restore the status quo, i.e., Au…O interactions were formed. Interestingly, in this instance, Au…Au interactions (3.09 Å) were formed but not in any other members of the series [32].…”

“…However, it proved possible to fine tune the electronic structures of the substituents in the arene rings to promote the formation of Au…π(arene) interactions. Figure 5b displays the molecular structure of Ph 3 PAu[SC(OMe) =NPh] [32], where the conventional Au…O interaction is found (3.05 Å). When the phosphorous-bound phenyl rings were substituted with comparatively electron-rich ptolyl rings to give (p-tol) 3 PAu[SC(OMe)=NPh], the gold atom was activated and a Au…π(arene) interaction (3.36 Å) was formed instead (Fig.…”

Synthesis and structures of gold(I) phosphine complexes containing monoanionic selenocarbamate ester ligands

“…However, to date no complexes containing deprotonated, monoanionic N-aryl-O-akylselenocarbamate ligands are known. Given that gold(I) phosphine complexes containing ArNHC(S)OMe (Ar = Ph, 4-NO 2 C 6 H 4 ) form a variety of supramolecular structures and are also strongly luminescent [16][17][18][19], we were interested in exploring the so far unknown chemistry of their selenium counterparts, in particular focusing on N-phenyl-O-methylselenocarbamate. The results of this investigation are presented herein [20].…”