Electron microscopy in cancer of the lung

Obiditsch-Mayer, I; Breitfellner, G

doi:10.1002/1097-0142(196805)21:5<945::aid-cncr2820210519>3.0.co;2-n

Cited by 25 publications

(6 citation statements)

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“…Although neoplastic squamous cells showed non‐keratinization histologically, the electron microscopic demonstration of tonofilaments and desmosomes suggested that the tumour was a moderately differentiated squamous cell carcinoma. These findings were similar to those reported in humans (Obiditsch‐Mayer and Breitfellner, 1968; Kimula, 1978).…”

Section: Discussionsupporting

confidence: 92%

Pulmonary Adenosquamous Carcinoma in a Dog

Sato

Itô

Shibuya

et al. 2005

Journal of Veterinary Medicine Series A

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A mass that developed in the lung of a 10-year-old mixed-breed dog was pathologically examined. Histopathological examination showed papillary and tubular growth of glandular epithelium-like cells in some areas and growth of squamous cells arranged in nests in other areas, showing coexistence of adenocarcinoma and squamous cell carcinoma in a lung tumour. Immunohistochemical staining with anti-keratin-cytokeratin antibody was strongly positive for cytoplasms in both components. Electron microscopically, the neoplastic cells of the adenocarcinoma component had features of glandular cells, with microvilli, numerous free ribosomes, large round secretory granules and intercellular desmosomes. Non-keratinized squamous cells had tonofilaments and intercellular desmosomes. These findings led to the diagnosis of primary adenosquamous carcinoma, which demonstrates phenotypic profiles characteristic of both epidermal keratinocytes and glandular epithelium.

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Section: Discussionsupporting

confidence: 92%

Pulmonary Adenosquamous Carcinoma in a Dog

Sato

Itô

Shibuya

et al. 2005

Journal of Veterinary Medicine Series A

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“…Secretion granules were not present and cytoplasmic organelles, other than mitochondria and free ribosomes, were poorly developed. These anaplastic tumor cells shared many ultrastructural characteristics with the small ("oat") cell type of bronchogenic carcinoma that has been reported previously (27)(28)(29). They could be readily differentiated from squamous cell carcinomas of the lung by the lack of tonofilaments and keratohyaline glanules, and from pulmonary adenocarcinomas by the absence of acinar formation with microvilli and large secretory vacuoles (28).…”

mentioning

confidence: 57%

Biosynthesis of Vasopressin In Vitro and Ultrastructure of a Bronchogenic Carcinoma

George¹,

Capen²,

Phillips³

1972

J. Clin. Invest.

119

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A B S T R A C T Tumors from patients with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) have been found to contain large amounts of the antidiuretic hormone vasopressin. A lung tumor from a patient with hyponatremia most likely due to SIADH was removed at surgery and found to contain 23.5 mU vasopressin/g wet weight by radioimmunoassay Slices of this tumor were incubated with phenylalanine-3H. Arginine vasopressin-H was purified from the incubate by Sephadex G-25 column chromatography in two different systems, performic acid oxidation, and gradient elution column chromatography with diethylaminoethyl Sephadex. As oxidation of vasopressin results in drastic conformational change with breaking of the ring of the cyclic polypeptide and addition of two cysteic acid residues per molecule, the radioactive material which eluted coincident with vasopressin both before and after this procedure was considered to be arginine vasopressin-'H. To our knowledge this is the first demonstration of in vitro biosynthesis of vasopressin by a tumor from a patient with SIADH.Ultrastructurally, the bronchogenic carcinoma was composed of small undifferentiated and granulated cells. The granulated neoplastic cells had well developed organelles (endoplasmic reticulum, free ribosomes) concerned with protein synthesis. Secretion granules present in the tumor cells were small, surrounded by a limiting membrane, and resembled those reported in polypeptide hormone-secreting cells.

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“…G. L. WHITELAW Fronm the Department of Pathology, University of Cambridge, Cambridge * Received for publication October 10, 1968 ELECTRON microscope studies of oat cell carcinoma of the bronchus have been carried out by several groups of workers (Laval, 1966;Nagaishi et al, 1965;Obiditsch-Mayer and Breitfellner, 1968; Pariente, Even and Brouet, 1966;Stoebner et al, 1967). No electron microscope paper has yet been published on a bronchial carcinoma known to be secreting antidiuretic hormone.…”

Section: Ultrastructure Of An Oat Cell Carcinoma Of the Bronchus Prodmentioning

confidence: 99%