Pulmonary Adenosquamous Carcinoma in a Dog

Sato, Tsuneko; Itô, Junko; Shibuya, Hitoshi; Asano, Kazushi; Watari, Toshihiro

doi:10.1111/j.1439-0442.2005.00773.x

Cited by 17 publications

(15 citation statements)

References 8 publications

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“…The clinical signs associated with pulmonary tumors are dry cough, hemoptysis, fever, exercise intolerance, weight loss, dysphagia, and anorexia. Lameness may occur with development of hypertrophic osteopathy (HO) [7,11,12,[14][15][16]. HO is characterized by swelling of the distal long bones with a periosteal reaction and is most frequently associated with lung tumors [1,5].…”

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Hypertrophic Osteopathy Associated with Pulmonary Adenosquamous Carcinoma in a Dog

Lee

Yoon

et al. 2012

J. Vet. Med. Sci.

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AbSTRAcT. A six-year-old intact female Maltese dog weighing 3.8 kg presented with a history of mild lameness and swelling on both forelimbs. Radiographic and computed tomographic views revealed an extensive periosteal reaction in all four limbs and a large round mass on the right middle lung lobe. A total lobectomy was performed and pulmonary adenosquamous carcinoma was histologically confirmed. A diagnosis of hypertrophic osteopathy (HO) secondary to a lung tumor was made. Periosteal proliferation decreased significantly after surgery; however, there was evidence of dyspnea, mass recurrence, and periosteal reaction three months postoperatively. This is the first case report of pulmonary adenosquamous carcinoma with HO in a dog in which we describe clinical, imaging, surgical, and histological findings. KEY WORDS: canine, hypertrophic osteopathy, pulmonary adenosquamous carcinoma.

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“…The owner did not consent to additional surgery and the dog has since been treated conservatively with analgesics, diuretics, and antibiotics. Adenocarcinoma is the most common histologic type of canine lung tumor, followed by squamous cell carcinoma, chondroma, fibroma, and plasmacytoma [14]. Adenosquamous carcinoma is uncommon in animals and humans [9,13].…”

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Hypertrophic Osteopathy Associated with Pulmonary Adenosquamous Carcinoma in a Dog

Lee

Yoon

et al. 2012

J. Vet. Med. Sci.

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“…In contrast, there is no effective protocol of chemotherapy for primary pulmonary carcinoma in veterinary medicine [18]. Platinum-containing drugs, such as cisplatin and carboplatin, have been used to treat canine primary pulmonary carcinoma, but positive results were not achieved [19]. There is only one report of a cat with well-differentiated pulmonary adenocarcinoma surviving for more than 1040 days (>115 days; overall median survival time in cat with pulmonary carcinoma) with no evidence of metastatic disease by pneumonectomy and adjuvant mitoxantrone chemotherapy [1].…”

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Immunohistochemical Detection of Proteins Associated with Multidrug Resistance to Anti-Cancer Drugs in Canine and Feline Primary Pulmonary Carcinoma

et al. 2010

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ABSTRACT. Fifty-two canine and eighteen feline primary pulmonary carcinomas were evaluated immunohistochemically for the expression of proteins associated with multidrug resistance to anti-cancer drugs. P-glycoprotein (PGP), multidrug resistance-related protein (MRP) and lung resistance-related protein (LRP) expression were frequently observed in neoplastic cells of all carcinoma types, and metallothionein (MT) expression was observed in about half of each carcinoma type. Furthermore, overlapping expression was detected in all positive cases. These results indicate that most canine and feline primary pulmonary carcinomas may have strong multidrug resistance, which is related to the PGP, MRP, LRP or MT expression. It might be difficult to treat canine and feline primary pulmonary carcinomas using anti-cancer drugs because of multidrug resistance.KEY WORDS: immunohistochemistry, lung resistance-related protein, metallothionein, multidrug resistance-related protein, P-glycoprotein.J. Vet. Med. Sci. 72 (5): [665][666][667][668] 2010 Human primary pulmonary carcinoma is divided into 2 groups; small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC). Surgical resection is not suitable for SCLC because of metastasis at the time of diagnosis in many cases; therefore, chemotherapy is recommended generally. For NSCLC, however, including adenocarcinoma, adenosquamous carcinoma and squamous cell carcinoma, chemotherapy is less effective; therefore, surgical resection is recommended generally [12]. Primary pulmonary tumors in domestic animals are uncommon to extremely rare, with a prevalence of 0.1-0.9% in dogs, a little higher than in cats [23]. In the treatment of canine and feline primary pulmonary carcinoma, surgical resection is recommended [18], but to reduce the risk of local recurrence and metastasis, adjuvant chemotherapy is required similarly to the treatment for human NSCLC. P-glycoprotein (PGP), a 150-170 kDa plasma membrane protein, belongs to the ATP binding cassette (ABC) superfamily of transporter proteins, and can extrude a range of hydrophobic anti-cancer drugs from the cell [20]. Overexpression of PGP is associated with resistance to different types of anti-cancer drugs (e.g. daunorubicin, doxorubicin, mitoxantrone, etoposide, teniposide, vinblastine, vincristine, mitomycin C, paclitaxel, actinomycin D and topotecan) [6]. Multidrug resistance-related protein (MRP), which belongs to the ABC superfamily as PGP, is a 190 kDa membrane-bound glycoprotein. MRP probably works by direct extrusion of cytotoxic drugs from the cell and/or by mediating sequestration of the drugs into intracellular compartments, both leading to a reduction in effective intracellular drug concentrations [16]. Overexpression of MRP is associated with resistance to doxorubicin, vincristine, actinomycin D, etoposide and colchicine [7,22]. Lung resistance-related protein (LRP) is a 110 kDa protein found in multidrug-resistant cell lines not expressing PGP. LRP is the main component of vault protein, and plays a role in ...

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“…In dogs, primary lung tumors are rare (1.2%) (Ogilvie et al 1989;Sato et al 2005), whereas metastatic involvement of this organ occurs frequently (Castellano et al 2006). As reported in the literature (Jennier and Sorenmo 2004;Marconato 2005), primary tumors are more often described in geriatric dogs (9.3-10.9 years), especially in boxers, labrador retrievers, springer spaniels, golden retrievers, and Irish Setters.…”

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confidence: 67%

A case of primary papillary disseminated adenocarcinoma of canine lung

et al. 2010

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Primary lung tumors are rare in dogs, whereas pulmonary metastatic neoplastic involvement is common. We describe a case of a 12-year-old male, mixed-breed dog with a 3-month history of coughing and dyspnea. The investigating protocol, which also includes transcutaneous pulmonary biopsy, allowed a diagnosis of lung adenocarcinoma that necroscopic findings confirmed as a primary neoplasia. The tumor exhibited a nodulardisseminated growth, mimicking the metastatic involvement of the lung, instead of the single-mass appearance that has been observed by other authors. The present report indicates that, although the incidence of canine primary lung neoplasms is markedly low, this condition must be considered in the differential diagnosis of lung diseases that cause coughing and dyspnea in older dogs.

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Pulmonary Adenosquamous Carcinoma in a Dog

Cited by 17 publications

References 8 publications

Hypertrophic Osteopathy Associated with Pulmonary Adenosquamous Carcinoma in a Dog

Hypertrophic Osteopathy Associated with Pulmonary Adenosquamous Carcinoma in a Dog

Immunohistochemical Detection of Proteins Associated with Multidrug Resistance to Anti-Cancer Drugs in Canine and Feline Primary Pulmonary Carcinoma

A case of primary papillary disseminated adenocarcinoma of canine lung

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