A case of primary papillary disseminated adenocarcinoma of canine lung

Conti, Maria Beatrice; Marchesi, Maria Chiara; Angeli, G; Lepri, Elvio; Marinetti, C.; Rueca, Fabrizio

doi:10.1007/s11259-010-9378-1

Cited by 5 publications

(6 citation statements)

References 6 publications

(6 reference statements)

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“…According to Leandro et al (2015) and Lorch et al (2019), primary lung neoplasms have a silent clinical course and represent an important challenge to the clinician, often with a guarded to unfavorable prognosis, when these neoplasms are found at a very advanced stage of development, concomitantly, when the first signs and symptoms are recognized, the most reported being dyspnea (6% to 24%) and cough (52% to 93%). Conti et al (2010) point out that around 25% of dogs with primary pulmonary neoplasms are often diagnosed as an incidental finding during thoracic radiographic evaluation for non-specific alterations, or during routine examinations, especially in senile animals.…”

Section: Discussionmentioning

confidence: 99%

“…According to Conti et al (2010), collecting material through guided cytology can lead to serious complications, such as hemothorax or pneumothorax. Leandro et al (2015), on the other hand, despite having used guided cytology as a diagnostic tool, the cytological analysis of the material did not guarantee a conclusive diagnosis, revealing inflammatory and degenerated cells, even though intercurrences with the procedure were not reported.…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis and surgical treatment of associated papillary lung adenocarcinoma to canine distemper: case report

Da Silva Junior,

Basso Machado,

Basso Machado

et al. 2024

PRW

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Lung neoplasms in dogs have a multifactorial etiology, and animals aged 10 or older are the most affected, with no sexual or racial predisposition. Adenocarcinoma is the most common type of cancer and represent around 80% of the cases. The aim of this study was to describe a case of an 11-year-old dog of no defined breed (SRD) with papillary lung adenocarcinoma and canine distemper virus. Clinical examination revealed a body condition score (BCS: 5.0), normocardial, tachypneic, normothermic, mild dehydration (5 - 6%), hyporexia, hypocolored mucous membranes, normodipsia, normuria and normoquesia. Hematological tests (blood count, biochemistry) were carried out, initially showing leukocytosis and regenerative anemia. Imaging tests of the chest (x-ray) and computed tomography (CT) showed a nodule, with approximately 7cm in circumference in the ventral portion of the right caudal lung lobe. Treatment was by thoracotomy to excise the nodule. The excised material was sent for histopathological and immunohistochemical diagnosis, which confirmed the diagnosis of lung adenocarcinoma. Infection with the distemper virus was confirmed by the identification of the Lentz corpuscle, which was found in the blood sample during the differential leukocyte count, when the animal was returned for re-evaluation. The animal did not respond to treatment and died 48 hours after the diagnosis of distemper, in response to cardiorespiratory arrest, 12 days after the removal of the nodule. Infection with the distemper virus led to an unfavorable prognosis and made post-surgical treatment impossible, culminating in the animal's death.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosis and surgical treatment of associated papillary lung adenocarcinoma to canine distemper: case report

Da Silva Junior,

Basso Machado,

Basso Machado

et al. 2024

PRW

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“…One in four dogs affected by this disease have no clinical signs, which makes diagnosis a challenge. Usually, it is an incidental radiography finding that can be mistaken by other diseases that affect the lungs, such as pneumonia [4].…”

Section: Discussionmentioning

confidence: 99%

Canine Diffuse Lepidic Predominant Adenocarcinoma

Rossato

Fiss

Sotili

et al. 2019

Acta Scientiae. Vet.

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Background: Due to their abundant vascular supply, the lungs are a usual metastatic site, with primary lung cancer presenting a low prevalence in dogs and cats. Among the primary pulmonary tumors afflicting dogs, lepidic carcinoma is the most common and can be classified by site of onset. Lepidic predominant adenocarcinoma is characterized by the proliferation of neoplastic cells along the pulmonary alveoli and pre-existing alveolar structures. Few reports of this specific tumor were found in the literature, so the objective of this study is to describe the clinical, pathological, and immunohistochemical findings of a dog with predominantly diffuse lepidic adenocarcinoma. Case: A 14-year-old, female, spayed, mixed-breed canine with a history of progressive weight loss, cough, respiratory distress, and pain while eating was brought in for a consultation. A presumptive diagnosis of pneumonia was suggested. However, in spite of treatment, the dog died, and a necropsy was performed. Upon gross examination, the lungs were diffusely enlarged, whitish, and stiffened with large and highly vascular nodules. Histopathological findings showed proliferation of neoplastic cells along the vascular walls and within the bronchioalveolar structures, with moderate fibrovascular stroma. The growth patterns resembled the pre-existing alveolar structures, with papillary protrusions into the alveolar lumen. After immunohistochemical evaluation, the definitive diagnosis was diffuse lepidic predominant adenocarcinoma. This tumor is uncommon and difficult to diagnose in the clinical veterinary routine, so it should be considered in the differential diagnosis of respiratory conditions in canines, especially in elderly animals with chronic clinical signs not responsive to antibiotic therapy. Complementary diagnostic examinations such as imaging, laboratory tests, and biopsy are indispensable to the early diagnosis of this lung neoplasm. Discussion: Due to its insidious character, primary lung cancer is underdiagnosed in veterinary medicine and is regularly an incidental x-ray finding. Affected dogs have no clinical signs, and this poses a diagnostic challenge. Primary lung cancer tends to be more prevalent in older and purebred animals. The most frequent clinical sign in dogs is a chronic nonresponsive cough, which can be misdiagnosed as another respiratory disease. Hematological findings, such as anemia, neutrophilia, and lymphopenia, can be related to tumor progression. Most reported cases of lepidic adenocarcinoma in dogs have a single pulmonary nodule, and the diffuse form is less common. In this case report, besides the presence of a single pulmonary nodule, there was also widespread involvement of the parenchyma. Histopathology was compatible with lepidic predominant adenocarcinoma, and immunohistochemistry was positive for pan-cytokeratin, confirming the epithelial origin of the tumor, and negative for TFF-1. Despite being a highly specific marker for lung cancer in dogs, TFF-1 has variable sensitivity among the different types of l...

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“…Sometimes even neoplastic cells can be found, but in several studies the correlation between BAL and histopathology was incomplete as not all neoplasms exfoliate (Norris et al, 2002;Conti et al, 2010). In a study of dogs with multicentric lymphoma involving the lung, bronchoalveolar lavage fluid contained neoplastic lymphocytes in 66% of cases (Hawkins et al, 1993).…”

Section: Bronchoalveolar Lavagementioning

confidence: 99%

Bronhoskopija i bronhoalveolarna lavaža u pasa i mačaka

Šmit,

Vučković

2023

Vet. stn. (Online)

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Diseases of the respiratory tract are widespread in small animal practice. Bronchoscopy and bronchoalveolar lavage are valuablediagnostic techniques that allow visualisation of the lumen and mucosa of a large part of the airway, and enable sampling. The decision on the sampling method depends on the patient’s assessment and imaging. Bronchoalveolar lavage is a safe and simple procedure indicated for diffuse diseases of the bronchi, pulmonary interstitium or alveoli. It is performed by infusion of 0.9% saline solution into the selected regional bronchus through the working channel of a bronchoscope or as a “blind technique” and removed as quickly as possible. The samples obtained by bronchoalveolar lavage are suitable for cytology, bacteriology and fungal cultures or other diagnostic tests such as PCR or specific antigen tests. Bronchoscopy requires appropriate and expensiveequipment, in addition to specialised training and experience of the physician performing the procedure. This review article provides an overview of the technique, equipment, most common indications, complications and interpretation of the results of bronchoscopy and bronchoalveolar lavage in dogs and cats.

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A case of primary papillary disseminated adenocarcinoma of canine lung

Cited by 5 publications

References 6 publications

Diagnosis and surgical treatment of associated papillary lung adenocarcinoma to canine distemper: case report

Diagnosis and surgical treatment of associated papillary lung adenocarcinoma to canine distemper: case report

Canine Diffuse Lepidic Predominant Adenocarcinoma

Bronhoskopija i bronhoalveolarna lavaža u pasa i mačaka

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