Electron Microscopic Evaluation of Altered Collagen Structure Induced by N-Monochloroglycine (GK-101)

Kronman, Joseph H.; Goldman, Melvin; Habib, C. M.; Mengel, L.

doi:10.1177/00220345770560122401

Cited by 27 publications

(12 citation statements)

References 4 publications

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“…In the 1970s, Habib et al [6] and Kronman et al [7] studied the effect of a nonspecific proteolytic agent, sodium hypochlorite (NaOCl), on carious dentine. Unfortunately, NaOCl not only dissolved necrotic organic material but also affected sound dentine [8].…”

Section: Introductionmentioning

confidence: 99%

Restoration of Strip Crown with a Resin-Bonded Composite Cement in Early Childhood Caries

Jeong

Kim

Shim

et al. 2013

Case Reports in Dentistry

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Background. Early childhood caries is a widely prevalent disease throughout the world. It is necessary to treat this condition in early childhood; however, child behavior management may be particularly challenging during treatment. To overcome this challenge, we used Carigel to remove caries and RelyX Unicem resin cement for strip crown restoration. It not only has the desired aesthetic effect but is also more effective for primary teeth, which are used for a shorter period than permanent teeth are. Case Presentation. We report a case of three pediatric patients with early childhood caries, in whom caries was removed by using Carigel to avoid the risk of pulpal exposure associated with high-speed handpieces. Subsequently, aesthetic restoration was performed using strip crown with RelyX Unicem self-adhesive resin cement. Conclusion. RelyX Unicem has the following advantages: (1) not requiring have any special skills for the dentist for performing the procedure, (2) decreased occurrence of bubbles during injection of the cement, and (3) overall short duration of the procedure. Thus, it is appropriate for the treatment of pediatric patients whose behavior is difficult to manage. However, further studies are required in order to establish the use of RelyX Unicem as a stable restorative material in early childhood caries.

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Section: Introductionmentioning

confidence: 99%

Restoration of Strip Crown with a Resin-Bonded Composite Cement in Early Childhood Caries

Jeong

Kim

Shim

et al. 2013

Case Reports in Dentistry

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“…2000). Presented in two components, one containing 0.1 m amino acids and pigment, the other 0.5% sodium hypochlorite, Carisolv™ is mixed to form a red gel of amino acids with electrostatic attraction to proteins in carious dentine (Kronman et al . 1977), and chloramines; potent halide disinfectants with tissue solvent action.…”

Section: Introductionmentioning

confidence: 99%

Preliminary in vitro evaluation of Carisolv™ as a root canal irrigant

Al-Kilani

Whitworth

Dummer

2003

International Endodontic Journal

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Within the limitations of this preliminary study (i). Carisolv cleaned root canals better than PBS and shows promise as an adjunct to root canal preparation; (ii). the action of Carisolv was enhanced by incubation times beyond 20 min whether or not ultrasound was applied; (iii). sodium hypochlorite solution remains the gold standard endodontic irrigant, provided that it is used with care and is contained in the canal system.

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“…A system using N-monochloro-DL-2-aminobutyric acid (NMAB) was then developed as an alternative to conventional mechanical caries removal [Schutzbank et al, 1978; review by Yip et al, 1995b]. The apparent mechanism of action of NMAB is considered to involve the chlorination of partially degraded collagen in carious dentine, and the conversion of hydroxyproline to pyrrole-2-carboxylic acid which initiates disruption of the altered collagen fibres in carious dentine [Habib et al, 1975;Kronman et al, 1977]. Clinical studies have demonstrated the efficacy of the method [McCune, 1986;Tavares et al, 1988;Yip et al, 1995a, b].…”

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confidence: 99%

Clinical Evaluation of Efficacy and Safety of a New Method for Chemo–Mechanical Removal of Caries

et al. 1999

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The aim of the study was to evaluate the clinical efficacy and safety of a new method (Carisolv™) for chemo–mechanical removal of caries. At four centres, 137 consecutive patients (64 females and 73 males aged 3–85 years, mean 35) entered a prospective, controlled, randomised open study. One primary caries lesion with distinct dentine involvement was selected per patient. A total of 116 lesions in permanent and 21 in deciduous teeth were selected. Caries was removed with traditional drilling or the new method. Gel was applied onto the carious dentine and the softened caries gently removed with specially designed hand instruments. New gel was applied and the procedure was repeated until no more debris could be removed and the surface was hard as judged by clinical criteria (probing and visual inspection). An independent examiner judged the cavity being caries–free or not, using clinical criteria. One hundred and thirteen patients were randomised for gel treatment and 24 for drilling. Three patients selected for drilling did not complete the treatment. Total caries removal was achieved in 106 cases with gel and in 19 with drilling. The reasons for incomplete caries removal were step–by–step excavation in 5 cases, unsuccessful caries removal in 1 case for each treatment, while 2 cases refused inspection. Mean (± SD) time for caries removal was 10.4 (±6.1) min with the gel method and 4.4 (±2.2) min with drilling. Mean volume of gel used was 0.4 (±0.2) ml. Eighty–two of 107 patients perceived that the new method caused less discomfort compared to drilling. Dentine caries was effectively removed using the Carisolv method without any adverse reactions.

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Electron Microscopic Evaluation of Altered Collagen Structure Induced by N-Monochloroglycine (GK-101)

Cited by 27 publications

References 4 publications

Restoration of Strip Crown with a Resin-Bonded Composite Cement in Early Childhood Caries

Restoration of Strip Crown with a Resin-Bonded Composite Cement in Early Childhood Caries

Preliminary in vitro evaluation of Carisolv™ as a root canal irrigant

Clinical Evaluation of Efficacy and Safety of a New Method for Chemo–Mechanical Removal of Caries

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