Preliminary <i>in vitro</i>
 evaluation of Carisolv™ as a root canal irrigant

Al-Kilani, M G; Whitworth, JM; Dummer, P. M. H.

doi:10.1046/j.1365-2591.2003.00675.x

Cited by 12 publications

(12 citation statements)

References 32 publications

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“…In addition, both ultrasonic irrigation and a higher concentration (5·5% or 12%) of sodium hypochlorite were necessary to achieve bacterial eradication from root dentine [33]. A recent study [34] also showed that Carisolv™ is effective in cleaning root canals, but only in combination with ultrasonic treatment.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of chemomechanical caries removal (Carisolv‘) with that of conventional excavation in reducing the cariogenic flora

Azrak¹,

Callaway²,

Grundheber³

et al. 2004

Int J Paed Dentistry

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Section: Discussionmentioning

confidence: 99%

Comparison of the efficacy of chemomechanical caries removal (Carisolv‘) with that of conventional excavation in reducing the cariogenic flora

Azrak¹,

Callaway²,

Grundheber³

et al. 2004

Int J Paed Dentistry

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“…However, in other reports this substance was placed on the dentine surface for a longer period of time (11,29), a fact that might have influenced the results of this work. In accordance, Al-Kilani et al (12) affirmed that Carisolv™ proved itself to be able to significantly enhance canal cleanliness, particularly with an exposure time over 20 min.…”

Section: Discussionmentioning

confidence: 64%

“…Al-Kilani et al (12) also verified root smear layer removal using Carisolv™. However, the effectiveness of this agent for safe debridement and disinfection of root canal systems, when used as an auxiliary chemical substance, is not well known yet.…”

Section: Introductionmentioning

confidence: 92%

The role of Carisolv™ and different auxiliary chemical substances in the removal of bovine root canal smear layer

et al. 2006

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To evaluate the effectiveness of Carisolv™and different auxiliary chemical substances in root canal smear layer (SL) removal. SL was produced in the centre of 40 hemi-disks of bovine root dentine. The samples were divided into four irrigation groups (G): GI (control) -0.9% NaCl; GII -1% NaOCl + 0.9% NaCl; GIII -Carisolv™ + 0.9% NaCl; GIV -1% NaOCl + 10% citric acid solution + 0.9% NaCl. The photomicrographs (SEM analysis) were coded (0 -absence of SL; 1 -moderate SL; 2 -dense SL with visible tubules; 3 -dense SL with no visible tubules). GIV was more effective in SL removal (P < 0.01). It should be noted that GI and GIII obtained score 3 in 100% of the samples (P > 0.01). Conclusion: NaOHCl, citric acid and NaCl solutions, when used together, presented a better performance in the removal of SL when compared to the other solutions. (J. Oral Sci. 48, [99][100][101][102][103] 2006)

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“…In regard to vital pulp therapy, NaOCl is recommended as a part of standard protocol in Carisolv chemomechanical caries removal system and partial pulpotomy by Cvek. Although NaOCl has been the irrigant of choice, it needs to be noted that low concentration is used in Carisolv gel [21] and Cvek partial pulpotomy [22] to prevent tissue toxicity. In the present study, bactericidal effect of NaOCl and EO waters containing HOCl was evaluated against S. mutans and E. faecalis.…”

Section: Discussionmentioning

confidence: 99%

The Antibacterial Efficacy and In Vivo Toxicity of Sodium Hypochlorite and Electrolyzed Oxidizing (EO) Water-Based Endodontic Irrigating Solutions

et al. 2020

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The objective of this study was to evaluate the antibacterial efficacy against Enterococcus faecalis and Streptococcus mutans and in vivo toxicity using embryonic zebrafish assays of sodium hypochlorite (NaOCl) and electrolyzed oxidizing (EO) water (containing hypochlorous acid (HOCl))-based root canal irrigating solutions. Methodology: Using 100 µL microbial count of 1 × 10 8 cfu/mL Enterococcus faecalis to mix with each 10 mL specimen of NaOCl or HOCl for designed time periods. The above protocol was also repeated for Streptococcus mutans. The concentration of viable microorganisms was estimated based on each standardized inoculum using a plate-count method. Zebrafish embryo assays were used to evaluate acute toxicity. Results: All the HOCl or NaOCl treatment groups showed > 99.9% antibacterial efficacy against Enterococcus faecalis and Streptococcus mutans. Zebrafish embryos showed almost complete dissolution in 1.5% NaOCl within 5 min. Both survival rates after being treated with 0.0125% and 0.0250% HOCl for 0.5 min or 1.0 min were similar to that of E3 medium. Conclusions: Both NaOCl and HOCl revealed similar antibacterial efficacy (> 99.9%) against Enterococcus faecalis and Streptococcus mutans. While 1.5% NaOCl fully dissolved the Zebrafish embryos, both 0.0125% and 0.0250% HOCl showed little in vivo toxicity, affirming its potential as an alternative irrigation solution for vital pulp therapy.

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Preliminary in vitro evaluation of Carisolv™ as a root canal irrigant

Cited by 12 publications

References 32 publications

Comparison of the efficacy of chemomechanical caries removal (Carisolv‘) with that of conventional excavation in reducing the cariogenic flora

Comparison of the efficacy of chemomechanical caries removal (Carisolv‘) with that of conventional excavation in reducing the cariogenic flora

The role of Carisolv™ and different auxiliary chemical substances in the removal of bovine root canal smear layer

The Antibacterial Efficacy and In Vivo Toxicity of Sodium Hypochlorite and Electrolyzed Oxidizing (EO) Water-Based Endodontic Irrigating Solutions

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