Electroformed pure iron as a new biomaterial for degradable stents: In vitro degradation and preliminary cell viability studies☆

Moravej, M.; Purnama, Agung; Fiset, M.; Couët, Jacques

doi:10.1016/j.actbio.2010.01.008

Cited by 163 publications

(117 citation statements)

References 30 publications

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“…phosphate which impeded additional degradation "by hindering oxygen diffusion" [39]. In addition, in [40], presence of hydroxide layer on the surface of electroformed iron was pointed as a cause of slowing down the degradation process in the static immersion test. As it appears in Figure 9, layers of corrosion products formed on the struts after seven-days are thicker than those formed after threeday immersion.…”

Section: Deformation and Failure Mechanismmentioning

confidence: 99%

Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Alavi

Trenggono

Champagne

et al. 2017

Metals

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Biodegradable metal foams have been studied as potential materials for bone scaffolds. Their mechanical properties largely depend on the relative density and micro-structural geometry. In this work, mechanical behavior of iron foams with different cell sizes was investigated under various compression tests in dry and wet conditions and after subjected to degradation in Hanks' solution. Statistical analysis was performed using hypothesis and non-parametric tests. The deformation behavior of the foams under compression was also evaluated. Results show that the mechanical properties of the foams under dry compression tests had a "V-type" variation, which is explained as a function of different geometrical properties by using a simple tabular method. The wet environment did not change the compression behavior of the iron foams significantly while degradation decreased the elastic modulus, yield and compression strengths and the energy absorbability of the specimens. The deformation of open cell iron foams under compression is viewed as a complex phenomenon which could be the product of multiple mechanism such as bending, buckling and torsion.

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Section: Deformation and Failure Mechanismmentioning

confidence: 99%

Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Alavi

Trenggono

Champagne

et al. 2017

Metals

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“…Os stents coronários inovaram o campo de cardiologia intervencionista e a sua implantação tornou-se modelo de auxílio para desobstruir o fluxo sanguíneo. Os stents coronários desenvolvidos até o presente momento podem ser divididos em quatro categorias: metálicos, metálicos revestidos, bioabsorvíveis e cobertos com fármacos [3] .…”

Section: -Tipos De Stents Coronáriosunclassified

“…A Figura 6 mostra a degradação do tubo de ferro puro após 3 e 9 meses de implantação, Figura 6-a e 6 b, respectivamente. [3] Figura 6 -Degradação do tubo de ferro puro após a-3 e b-9 meses de implantação Fonte: Adaptado de Mueller e colaboradores. 2012 (57).…”

Section: -Implantações Do Ferro Puro Em Mamíferosunclassified

Viabilidade Da Utilização Stents Metálicos Biodegradáveis

Caumo¹,

Silva²,

Tavares³

et al. 2017

Anais Do Congresso Anual Da ABM

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ResumoA aterosclerose é um termo geral relativo a diversas doenças relacionadas ao espessamento e perda de elasticidade da parede arterial. Atualmente os maus hábitos alimentares, combinados ao sedentarismo, podem levar a ocorrência de elevados níveis de colesterol na corrente sanguínea. Este fato aumenta o risco de obstrução dos vasos sanguíneos, limitando o fluxo do sangue para o coração. Desta maneira, para desobstruir o vaso sanguíneo e manter o lúmen arterial aberto é colocado um stent. Os stents são redes, normalmente de ligas metálicas, que servem para desobstruir os vasos sanguíneos. O tratamento de doenças das artérias coronárias e periféricas usando stents metálicos tem sido adotado nas intervenções médicas nos dias de hoje. No entanto, surgiram argumentos que indicavam os benefícios de remover o stent após este ter feito a desobstrução, originando desenvolvimento de stents biodegradáveis. Estes exigem propriedades mecânicas adequadas, biocompatibilidade adequada, garantindo uma baixa toxicidade dos produtos de degradação. Com isso, o objetivo deste trabalho é o estudo preliminar sobre stents metálicos biodegradáveis, como ferro puro, magnésio. Além disso, avaliar se os mesmos são adequados para aplicação à stents biodegradáveis, avaliando as propriedades mecânicas dos metais, biocompatibilidade e toxicidade dos compostos degradados ao longo do tempo de implantação. Palavras-chave: Aterosclerose; Biodegradável; Ferro; Stent. VIABILITY FOR USE METAL BIODEGRADABLE STENTS AbstractThe atherosclerosis is a general term for several diseases related to thickening and loss of elasticity of the arterial wall. Currently the bad eating habits, combined with physical inactivity can lead to occurrence of high levels of cholesterol in the bloodstream. This fact increases the risk of obstruction of the blood vessels, limiting the flow of blood to the heart. This way, to clear the blood vessel and maintain the arterial lumen open is placed a stent to assist the flow of blood. The stents are networks, usually of metal alloys, which serve to clear the blood vessels. The treatment of diseases of the coronary arteries and peripheral using metallic stents have been adopted in medical interventions in today. However, there have been arguments that indicated the benefits of removing the stent after it has done the clearing, that led to the development of biodegradable stents. These require appropriate mechanical properties, biocompatibility, ensuring a low toxicity of the products of degradation. The objective is the preliminary study on biodegradable metallic stent. In addition, metals properties such as ductility, yield and tensile strength, adequate biocompatibility and low toxicity of the compounds degraded all along the time of deployment.

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“…AMS, Biotronik GmBH) have been moved to clinical arena since 2006 [6]. Nevertheless, magnesium degrades too rapidly and it is generally agreed that magnesium has to be further developed in order to reduce its degradation rate [7]. New alloys are still in huge demand and iron and its alloys might be one such choice.…”

Section: Introductionmentioning

confidence: 99%

“…New alloys are still in huge demand and iron and its alloys might be one such choice. In recent years, pure iron as a biodegradable material has been investigated [7][8][9]. In vivo experiments show that the degradation resistance is not as satisfactory as in in-vitro experiments [7].…”

Section: Introductionmentioning

confidence: 99%

DEGRADATION BEHAVIOR OF A BIODEGRADABLE Fe-Mn ALLOY PRODUCED BY POWDER SINTERING

Zhang

Wang

Cao

et al. 2012

Int. J. Mod. Phys. Conf. Ser.

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Biodegradable stenting and implantation materials have received considerable attention in biomaterials community, with magnesium having been received most wide attention. However, magnesium corrodes too fast by nature, in human body environment. A new type of biodegradable metal -Fe and its alloys -has been introduced in recent years. In this study, a Fe35wt%Mn alloy was produced using powder sintering. Powder mixture was mechanically milled, pressed and then sintered to consolidate powder compacts. Microstructure characterization and hardness measurement were carried out on the as-sintered samples. In vitro degradability evaluation of the samples was performed in 5% NaCl and Simulated Body Fluid (SBF) media. The experimental results show that a higher porosity results in a higher degradation rate. All samples, with porosity being from 6.5% to 12.2 %, revealed a degradation rate from 0.6 to 1.4 mm/year.

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Electroformed pure iron as a new biomaterial for degradable stents: In vitro degradation and preliminary cell viability studies☆

Cited by 163 publications

References 30 publications

Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Investigation on Mechanical Behavior of Biodegradable Iron Foams under Different Compression Test Conditions

Viabilidade Da Utilização Stents Metálicos Biodegradáveis

DEGRADATION BEHAVIOR OF A BIODEGRADABLE Fe-Mn ALLOY PRODUCED BY POWDER SINTERING

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