Electrodeposition and characterization of iridium oxide as electrode material for neural recording and stimulation

Hasenkamp, Willyan; Musa, Silke; Arcire, Alexandru; Eberle, Wolfgang; Bartic, Carmen

doi:10.1007/978-3-642-03889-1_126

Cited by 5 publications

(9 citation statements)

References 7 publications

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“…As chronic stimulation electrode site materials, metals including tungsten, platinum, iridium, tantalum pentoxide, and titanium nitride have been extensively used for their electrical charge-injection properties and biocompatibility (Cogan, 2008; Fattahi et al, 2014; Meijs et al, 2015). For its remarkably increased charge storage and injection capacity and high corrosion resistivity, iridium oxide has been also widely utilized as a coating material (Meyer et al, 2001; Hasenkamp et al, 2009) to enhance the performance and the durability of the electrode. Carbon nanotubes (Jiang et al, 2011; Schmidt et al, 2013) and conducting polymers such as poly(3,4-ethylene dioxythiophene) (PEDOT) and poly(styrene sulfonate) (PSS) (Cui and Martin, 2003; Pranti et al, 2018) are attracting considerable attention as alternatives to the metal electrodes and coatings for their biocompatibility and tunable electrical properties.…”

Section: Implantable Electrodes In Neurological and Neuropsychiatric mentioning

confidence: 99%

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

et al. 2019

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The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment of traumatic and neurodegenerative disorders. Electrodes have been exploited in a wide number of neural interface devices, such as deep brain stimulation, which is one of the most successful therapies with proven efficacy in the treatment of diseases like Parkinson or epilepsy. However, one of the main caveats related to the clinical application of electrodes is the nervous tissue response at the injury site, characterized by a cascade of inflammatory events, which culminate in chronic inflammation, and, in turn, result in the failure of the implant over extended periods of time. To overcome current limitations of the most widespread macroelectrode based systems, new design strategies and the development of innovative materials with superior biocompatibility characteristics are currently being investigated. This review describes the current state of the art of in vitro, ex vivo , and in vivo models available for the study of neural tissue response to implantable microelectrodes. We particularly highlight new models with increased complexity that closely mimic in vivo scenarios and that can serve as promising alternatives to animal studies for investigation of microelectrodes in neural tissues. Additionally, we also express our view on the impact of the progress in the field of neural tissue engineering on neural implant research.

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Section: Implantable Electrodes In Neurological and Neuropsychiatric mentioning

confidence: 99%

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

et al. 2019

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“…These functional electrical stimulations rely on either high density microelectrode array or electrode with small size to minimize the damnification when implanted. However, when the density of stimulating sites increases or the electrode size decreases, the geometrical area of stimulating sites will decrease to lead to the increasing impedance and thus power consumption [6][7][8]. One way to solve this problem is modifying the stimulating sites to achieve large effective surface area and low impedance.…”

Section: Introductionmentioning

confidence: 97%

Investigation of flexible electrodes modified by TiN, Pt black and IrO x

Tang

Gui

et al. 2011

Sci. China Technol. Sci.

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TiN, platinum (Pt) black and iridium oxide are introduced to the stimulating sites to improve the performance of the flexible electrode. Low temperature process is used to fabricate the modifying films. TiN is coated on the gold sites by magnetron sputtering while platinum black and iridium oxide are coated by electroplating and electrodeposition, respectively. The impedance of the electrode decreases dramatically after modification. The combined analysis of surface morphology and cyclic voltammograms (CV) in phosphate buffer saline (PBS) solution indicates that the modified electrode sites have larger electrode-electrolyte capacitance and smaller faradic resistance than unmodified sites, thus they have smaller electrochemical impedances.flexible electrodes, modification, impedance, cyclic voltammograms (CV)

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“…In central region of the frequency range in the curve, phase tends to -90º, indicating a capacitive element (in this case, the interface capacitance) while at low frequencies, phase tends to back to zero. Comparatively, TiN has a more capacitive response at a higher frequency than IrOx [16,33].…”

Section: Impedance Spectroscopymentioning

confidence: 99%

“…Another important data that cyclic voltammetry test provides is Cathodic Charge Storage Capacity (CSCc) of the stimulation electrodes, which basically measures the total amount of charge available during a stimulation pulse [19]. CSCc is calculated as the integral of the cathodic current (negative current) with respect to time in a cyclic voltammogram with low scan rate over a range that is within the electrolysis window of water [33].…”

Section: B Electrical Stimulation Testmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication and Characterization of 60 Channel Microelectrode Arrays for Recording and Stimulation from Cardiac Cells in Culture

Gomes¹,

Barros²,

Filho³

et al. 2020

JICS

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Stimulation and recording of nerve cells is a procedure used for several applications, such as clinical therapies, study of basic neuroscience, and neural prostheses. Microtechnology and advances in material science have allowed to produce more sophisticated devices and with more functions. This paper focuses on the fabrication of planar 60 – channel Microelectrode Arrays (MEAs). The electrical characterization of the noise level from the TiN electrodes showed good sensitivity to noise, compatible with commercial systems. These electrodes received an artificial electrocardiogram signal (ECG) from a function generator and registered the same input signal but with lower amplitude. Finally, both cyclic voltammetry curves of the produced MEA and the commercial MEA exhibited similar shape, but the current density of the first one was significantly higher than in MCS – MEA, with an order difference of magnitude.

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Electrodeposition and characterization of iridium oxide as electrode material for neural recording and stimulation

Cited by 5 publications

References 7 publications

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

Investigation of flexible electrodes modified by TiN, Pt black and IrO x

Fabrication and Characterization of 60 Channel Microelectrode Arrays for Recording and Stimulation from Cardiac Cells in Culture

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