Electrochemistry of a novel monoruthenated porphyrin and its interaction with DNA

Interaction of 3′-azido-3′-deamino daunorubicin with DNA: Multispectroscopic and molecular modeling

“…Binding of drug molecules to DNA occurs primarily through three modes: binding interactions with minor groove of the DNA double helix, electrostatic interactions with the exterior nucleic acid sugar-phosphate structure, and intercalative interaction between the stacked base pairs of native DNA in the major groove [7]. Among the three modes, the most effective mode of the drugs targeted to DNA is intercalative binding [8].…”

Study of the Interaction of Ciprofloxacin and Sparfloxacin with Biomolecules by Spectral, Electrochemical and Molecular Docking Methods

“…Biomolecules binding has long been considered one of the most important physicochemical characteristics of drugs, playing a potential role in distribution, excretion, and therapeutic effectiveness [1][2][3][4][5][6][7]. The study of the interaction of the drug with biomolecules like DNA, RNA and BSA plays a key role in pharmacology and it is of great significance for designing and synthesizing the new drugs targeted to the biomolecules and their effectiveness depends on the mode and affinity of the binding [2,3].…”

“…The recognition of DNA binders involves a complex relationship of different interactive forces. It includes the intercalation between adjacent base pairs, intrusion into the minor and major groove and electrostatic interaction [1,4]. The resulting drug-DNA complex is stabilized by a number of noncovalent (such as van der Waals interactions, hydrophobic forces and hydrogen bonds) and covalent interactions.…”

Interaction of sulfadiazine with DNA on a MWCNT modified glassy carbon electrode: Determination of DNA

“…Thus, in order to obtain the biochemical mechanisms of prevention and treatment of human diseases, great efforts have been made to investigate the interaction between DNA and drug molecules [2,3]. Moreover, nucleic acids interaction with drugs is a fundamental issue in life phenomena.…”