Interaction of sulfadiazine with DNA on a MWCNT modified glassy carbon electrode: Determination of DNA

Fotouhi, Lida; Hashkavayi, Ayemeh Bagheri; Heravi, Majid Μ.

doi:10.1016/j.ijbiomac.2012.11.021

Cited by 28 publications

(18 citation statements)

References 35 publications

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“…These nanoparticles provide the researchers with more efficient techniques for interfacing DNA recognition with electrochemical signal transduction. The recent electrochemical drug‐DNA binding studies based on nanomaterials are summarized in Table ; the types of drugs that have been analyzed are anticancer agents antibiotics, antihistaminic, antivirals, nonsteroidal anti‐inflammatory drugs, neurotransmitters, vitamins and retroviral . Upon discovery of the advantages that nanomaterials could bring to analytical science, the first researches regarding to DNA‐drug interaction were done in solution.…”

Section: Nanomaterialsmentioning

confidence: 99%

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Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

2019

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The interaction of drugs with DNA has been searched thoroughly giving rise to an endless number of findings of undoubted importance, such as a prompt alert to harmful substances, ability to explain most of the biological mechanisms, or provision of important clues in targeted development of novel chemotherapeutics. The existence of some drugs that induce oxidative damage is an increasing point of concern as they can cause cellular death, aging, and are closely related to the development of many diseases. Because of a direct correlation between the response, strength/ nature of the interaction and the pharmaceutical action of DNA‐targeted drugs, the electrochemical analysis is based on the signals of DNA before and after the interaction with the DNA‐targeted drug. Nowadays, nanoscale materials are used extensively for offering fascinating characteristics that can be used in designing new strategies for drug‐DNA interaction detection. This work presents a review of nanomaterials (NMs) for the study of drug‐nucleic acid interaction. We summarize types of drug‐DNA interactions, electroanalytical techniques for evidencing these interactions and quantification of drug and/or DNA monitoring.

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Section: Nanomaterialsmentioning

confidence: 99%

“…Using the drug−DNA interaction, useful analytical information can be obtained from the increased DNA (guanine) response, in a manner that one can determine several drugs concentration using an electrochemical approach in complex biological matrices .…”

Section: Nanomaterialsmentioning

confidence: 99%

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

2019

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“…We then deduced there were some changes in absorbance and the position of the band would red shift when DES interacts with DNA. The possible reasons to explain why the spectral have some effects may be that [27,28] it can cause an energy decrease, and a decrease of the π→π* transition energy when the empty π* -orbital of the small molecule couples with the π-orbital of the DNA base pairs. It shows that their electron clouds affected and overlapped each other statically to form an association.…”

Section: Determination Of Uv-vis Absorption Spectroscopymentioning

confidence: 99%

Study of Dna-Diethylstilboestrol Interaction Using Graphene-Based Thin-Film Sensor and Uv-Vis Spectroscopy

Chen

et al. 2018

J. Chil. Chem. Soc.

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The graphene-modified glassy carbon electrode (Gr/GCE) was fabricated by casting graphene (Gr). Some electrochemical parameters for diethylstilbestrol (DES) detection, such as pH, scan rate, and accumulation time were discussed. The interaction of DES with DNA at a Gr/GCE was studied by electrochemical method and factors influencing the interaction were optimized. Under the optimized conditions, the results revealed that the peak current decreased and the peak potential shifted to the positive side after adding DNA into the solution containing DES. We deduced that the interaction of DES with DNA mainly is intercalation. The interaction of DES with DNA was studied by ultraviolet and visible (UV-Vis) absorption spectroscopy. Also, with the addition of DNA, hyperchromic effect and small red shifts were observed in its UV-VIS spectra upon addition of DNA, results indicated that the DES molecule intercalated into the DNA, and the complex of DES-DNA was formed.

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“…Moreover, the noncovalent DNA interactions include intercalative, electrostatic and groove (surface) binding of compounds along outside of DNA helix, along major or minor groove. It has been reported that FSdsDNA can provide three distinctive binding sites for all compounds; namely, groove binding, electrostatic binding to phosphate group and intercalation [49]. This behavior is of great importance with regard to the relevant biological role of porphyrins and metallo porphyrins in the body.…”

Section: Dna Binding Studiesmentioning

confidence: 99%