Electrochemiluminescence from successive electro- and chemo-oxidation of rifampicin and its application to the determination of rifampicin in pharmaceutical preparations and human urine

Liang, Yao-Dong; Song, Junfeng; Xu, Mengli

doi:10.1016/j.saa.2006.07.036

Cited by 18 publications

(15 citation statements)

References 43 publications

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“…Ghoneim et al (2003) reported the utilization of a procedure of voltammetry of adsorptive redissolution, employing a mercury electrode for the determination of isoniazid in pharmaceutical formulations and in biologic fluids. Wahdan (2005) and Liang et al (2007) studied the voltammetric behavior of rifampicin oxidation, reporting that the mechanism involves the same typical number of electrons and protons as for hydroquinones. Hammam et al (2004), by adsorptive redissolution voltammetry, and Wahdan (2005), by cyclic voltammetry and linear scanning, developed methodologies for the determination of isoniazid and rifampicin, in pharmaceutical formulations and biologic fluids, employing electrode of carbon paste.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Leandro

Carvalho

Giovanelli

et al. 2009

Braz. J. Pharm. Sci.

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Tuberculosis remains a major public health problem, especially in developing countries. Brazil presents the largest number of cases in Latin America and is among the 22 countries considered priorities by the World Health Organization (WHO). The Rio de Janeiro state has the largest number of cases registered in the country. The treatment of patients, commonly, makes use of the drugs isoniazid and rifampicin for six months. This study aimed to develop and validate an electroanalytical methodology, using the technique of differential pulse voltammetry for the determination of these drugs in the associated form, in order to evaluate the quality of medicines distributed in the state of Rio de Janeiro. The potential reduction for the isoniazid and rifampicin were -1.10 and -0.90 V. The developed and validated electroanalytical method presented a linear range of 0.25 to 1.25 mg/L to isoniazid, limits of detection and quantification of 0.05 and 0.14 mg/L, and recovery of 98.2 ± 0.4%; a tracking linear of 0.40 to 2.00 mg/L for rifampicin, with limits of detection and quantification of 0.07 and 0.19 mg/L and recovery of 95.8 ± 0.6%. Six lots of medicines from two pharmaceutical companies were analyzed. Only one of the samples showed unsatisfactory levels of rifampicin.Uniterms: Isoniazid. Rifampicin. Tuberculosis/treatment. Tuberculostatics/quantitative analysis. Differential pulse voltammetry.A tuberculose continua sendo um importante problema de saúde pública, especialmente em países em desenvolvimento. O Brasil apresenta o maior número de casos da América Latina, estando entre os 22 países considerados prioritários nas ações de controle da doença pela Organização Mundial da Saúde (OMS). No Brasil, o Rio de Janeiro é o estado com o maior número de casos registrados no país. O tratamento de doentes com tuberculose faz uso dos fármacos isoniazida e rifampicina durante seis meses. O presente trabalho objetivou desenvolver e validar metodologia eletroanalítica, utilizando a técnica de voltametria de pulso diferencial, para a determinação desses dois princípios ativos na forma associada e avaliar a qualidade dos medicamentos distribuídos no estado do Rio de Janeiro. Os potenciais de redução para a isoniazida e rifampicina foram respectivamente -1,10 e -0,90 V. O método eletroanalítico desenvolvido e validado apresentou para a isoniazida faixa linear de 0,25 a 1,25 mg/L, limites de detecção e quantificação de 0,05 e 0,14 mg/L e recuperação de 98,2 ± 0,4%; para a rifampicina faixa linear de 0,40 a 2,00 mg/L, limites de detecção e quantificação de 0,07 e 0,19 mg/L e recuperação de 95,8 ± 0,6%. Foram analisados 6 lotes de medicamentos de dois laboratórios farmacêuticos. Apenas uma das amostras apresentou teor de rifampicina insatisfatório.Unitermos: Isoniazida/determinação. Rifampicina/determinação. Tuberculostáticos/análise quantitativa. Tuberculose/tratamento. Voltametria de pulso diferencial/utilização.

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Section: Introductionmentioning

confidence: 99%

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Leandro

Carvalho

Giovanelli

et al. 2009

Braz. J. Pharm. Sci.

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“…-generated singlet oxygen ( 1 O 2 ), an excited state of molecular oxygen, 21,26,27 and the details are summarized as follows: 20 The reasonable explanation about the rifampicin enhancement of 5 …”

Section: Hsomentioning

confidence: 99%

“…Yang et al 19 changed the HPLC with the CL detection, and detected the rifampicin and isoniazid with a hexacyanoferrate(III) CL system, in fact, the change was difficult and the detection limit was also not satisfactory. Liang et al 20 reported that they detected the rifampicin with an electrochemiluminescence method, which was sensitive, and the results in the determination of rifampicin in real samples were relatively satisfactory. The peroxomono-sulfate-cobalt(II) CL system has been developed as a potential CL analysis method in determination of drugs and environmental contamination, such as riboflavin in Vitamin B 2 tablets and injections and 2-naphthol, benzothiazole and humic substance in natural water.…”

Section: Introductionmentioning

confidence: 99%

“…Based on the strong enhancing effect of rifampicin on this CL system, a new, rapid, simple, sensitive and inexpensive method was proposed to determinate rifampicin. Compared with the other CL methods, [18][19][20] it has much better linearity and lower detection limit. Furthermore, the method has been used for the determination of rifampicin in real eye drop and capsule samples with satisfactory results.…”

Section: Introductionmentioning

confidence: 99%

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Determination of Rifampicin by Peroxomonosulfate‐Cobalt(II) Chemiluminescence System

Zhang

Zhao³

et al. 2008

Chin. J. Chem.

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Rifampicin can enhance the chemiluminescence (CL) of peroxomonosulfate-cobalt(II) system, and the CL intensity is strongly dependent on the rifampicin concentrations. Based on this phenomenon, a rapid and sensitive flow injection CL method was developed for the determination of rifampicin. The relative CL intensity was linear with the rifampicin concentration over the range of 5×10 -8 to 1×10 -6 g•mL -1 (r＝0.9991), the detection limit was 7×10 -9 g•mL -1 (S/N＝3), and the relative standard deviation was 2.7% for 6×10 -7 g•mL -1 rifampicin (n＝11).Furthermore, this method was successfully applied to the determination of rifampicin in real eye drop and capsules sample.

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“…Numerous methods have been previously reported for the rifampicine determination including liquid chromatography [10 -12], electrochemiluminescence [13], nuclear magnetic resonance spectroscopy [14] and adsorptive stripping voltammetry (AdSV) [15 -18]. For rifampicine determination by AdSV HMDE [15], carbon paste [16 -18] and modified carbon paste electrodes [18] were used.…”

Section: Introductionmentioning

confidence: 99%

New Protocol for Determination of Rifampicine by Adsorptive Stripping Voltammetry

Tyszczuk

Korolczuk

2008

Electroanalysis

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For determinations of organic compounds by adsorptive stripping voltammetry till now the same material of the electrode has been used for the accumulation and stripping steps. This paper describes a new protocol for extending the range of organic compounds, which can be determined by adsorptive stripping voltammetry. In the proposed procedure the accumulation step was performed on the electrode modified by a lead film, which assures adsorption of the studied species on the modified electrode and then the stripping step of the accumulated substance was performed on the support of the lead film electrode. As an example rifampicine was accumulated by adsorption at the lead film electrode while in the stripping step lead film and then the accumulated rifampicine were oxidized at a glassy carbon electrode. Using an acetate buffer as a supporting electrolyte a calibration graph for rifampicine in the range from 2.5 Â 10 À10 to 1 Â 10 À8 mol L À1 was obtained. The detection limit for rifampicine following 60 s accumulation time was equal to 9 Â 10 À11 mol L À1 . The obtained detection limit was comparable or lower than reported previously for other stripping voltammetric procedures. The proposed procedure was applied to rifampicine determination in pharmaceutical preparation.

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Electrochemiluminescence from successive electro- and chemo-oxidation of rifampicin and its application to the determination of rifampicin in pharmaceutical preparations and human urine

Cited by 18 publications

References 43 publications

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Determination of Rifampicin by Peroxomonosulfate‐Cobalt(II) Chemiluminescence System

New Protocol for Determination of Rifampicine by Adsorptive Stripping Voltammetry

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