Electrochemical studies and square-wave voltammetric determination of fenofibrate in pharmaceutical formulations

Abstract

The electrochemical reduction of fenofibrate at a hanging mercury drop electrode (HMDE) was investigated by cyclic voltammetry, square-wave voltammetry, and chronoamperometry. Different buffer solutions were used over a wide pH range (3.0-10.0). The best definition of the analytical signals was found in borate buffer (pH 9.0)-tetrabutylammonium iodide mixture containing 12.5% (v/v) methanol at -1.2 V (versus Ag/AgCl). According to cyclic voltammetric studies, the reduction was irreversible and diffusion controlled. The diffusion coefficient was 2.38x10(-6) cm2 s(-1) as determined by chronoamperometry. Under optimized conditions of square-wave voltammetry, a linear relationship was obtained between 0.146-4.96 microg mL(-1) of fenofibrate with a limit of detection of 0.025 microg mL(-1). Validation parameters such as sensitivity, accuracy, precision, and recovery were evaluated. The proposed method was applied to the determination of fenofibrate in pharmaceutical formulations. The results were compared with those obtained by a published high-performance liquid chromatography method. No difference was found statistically.

Catalytic Adsorptive Stripping Voltammetry at a Carbon Paste Electrode for the Determination of Amiodarone

“…In view of its chemical structure, amiodarone was known as (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone hydrochloride, and belongs to benzoyl derivatives. The polarographic behaviors of benzoyl derivatives such as fenofibrate, ketoprofen, amiodarone, mebendazole and flubendazole have been studied in aqueous and organic media and used for analytical purpose, [22][23][24][25][26] respectively. All these derivatives showed a polarographic reduction wave, which was attributed to the reduction of the electroactive benzoyl group via a two-electron and two-proton addition.…”

Simultaneous Quantitative Resolution of Atorvastatin Calcium and Fenofibrate in Pharmaceutical Preparation by Using Derivative Ratio Spectrophotometry and Chemometric Calibrations

“…We also determined its impurities, enantiomers, intermediates and metabolites. Fenofibrate is determined by spectrophotometry, 17 square-wave voltammetry, 18 HPLC, and nuclear magnetic resonance (NMR), [19][20][21] in pharmaceutical formulations, raw materials, plasma and serum, and impurities, and in bioactive metabolites.…”

High-performance liquid chromatography and derivative spectrophotometry for simultaneous determination of pravastatin and fenofibrate in the dosage form

“…Fenofibrate is official in USP (11) and BP (12) but different methods have been cited in the literature for determination of fenofibrate involving HPLC-UV (13,14) and HPLC-MS (15), voltammetry (16) and differential pulse polarographic techniques (17). A stability indicating UPLC method for simultaneous determination of atorvastatin, fenofibrate and their impurities in tablets was developed and validated (14).…”