Electrochemical Sensor for Meropenem Therapeutic Monitoring in Human Plasma Based on Carbon Nanotubes Modified Basal Pyrolytic Graphite Electrode

Abstract

A sensitive, precise, and fast differential pulse voltammetric method has been developed for determination of meropenem (MER) in pure form, pharmaceutical dosage form, and human plasma. The fabricated sensors are based on basal-plane pyrolytic graphite electrode substrates that was modified by coating the surface with carbon nanotubes. The modified electrode showed detectable enhancement of the anodic peak current of meropenem from 25.8 to 35.7 µA. The effect of both pH and scan rate on peak current and potential were studied, and the optimum conditions were found to be at pH = 3.0 and scan rate of 100 mV.s-1. A linear response was obtained over the concentration range of 3.0×10-7 to 7.0×10-5 M MER in an aqueous buffer solution. The suggested sensor is highly sensitive, has a short response time, and is capable of MER detection as low concentration as 1.5×10-6 M in human plasma. The proposed sensor shows a great potential towards future fabrication of a point-of-care device to monitor MER level in patients’ plasma to ensure drug safety and efficacy for patients in intensive care unit.

Novel solid-contact ion-selective electrode based on a polyaniline transducer layer for determination of alcaftadine in biological fluid

“…To enhance electrical signal stability of SC-ISEs many ion-toelectron transducers have been introduced such as solidcontact functional materials for instance; conductive polymers (CPs), [16][17][18][19][20] and nanomaterials. [21][22][23][24][25][26][27] Addition of these materials improved sensors robustness and reliability, while being calibrated and maintenance free. In comparison to the classical liquid contact, SC-ISEs polymeric membrane achieved the following properties; they become easier in design, more exible and compatible with modern 3D printing and can be miniaturized.…”

Synthesis of Prussian Blue Analogue and Its Catalytic Activity toward Reduction of Environmentally Toxic Nitroaromatic Pollutants

“…Various nanoparticles have been synthesized that exhibit interesting behavior such as conductive , and catalytic and optical characteristics dependent on size and surface modifications. From this perspective, the use of nanocatalysts in the reduction of nitroaromatics has received a lot of attention in the last years.…”