Novel solid-contact ion-selective electrode based on a polyaniline transducer layer for determination of alcaftadine in biological fluid

Abstract

Fabrication of a novel ion selective electrode for determining alcaftadine in rabbit aqueous humor was achieved using glassy carbon electrode substrate electrochemically modified with polyaniline as an ion-to-electron transducer layer.

A novel green spectrofluorimetric method for simultaneous determination of antazoline and tetryzoline in their ophthalmic formulation

“…ANT and TET are official drugs as ANT is described in the British pharmacopeia [19] while, TET is described in the US pharmacopeia [20]. A review of the literature revealed a number of methods for determining ANT and TET including spectrophotometric [21], high‐performance liquid chromatography (HPLC) [22, 23], and high‐performance thin‐layer chromatography (HPTLC) [24–26] methods. Accordingly, the proposed work is considered to be the first attempt in reacting both drugs with dansyl chloride (DNS‐Cl) yielding a highly fluorescent derivatives followed by a successful application of a second derivative technique on synchronous spectrofluorimetric spectra for their simultaneous determination [27].…”

“…ANT and TET are official drugs as ANT is described in the British pharmacopeia [19] while, TET is described in the US pharmacopeia [20]. A review of the literature revealed a number of methods for determining ANT and TET including spectrophotometric [21], highperformance liquid chromatography (HPLC) [22,23], and highperformance thin-layer chromatography (HPTLC) [24][25][26] methods.…”

Novel Carbon Nanotubes/Gold Nanoparticles Modified Carbon Paste Electrochemical Sensor for Antazoline Determination in Aqueous Humor

“…ANT, TET and XLO are official drugs in either European pharmacopeia 46 or US pharmacopeia. 47 Literature survey encountered various methods for ANT and TET determination including spectrophotometric, 48 high performance liquid z E-mail: amr.bekhet@pharma.cu.edu.eg chromatographic (HPLC), 49,50 and high-performance thin layer chromatographic [51][52][53] methods. While for ANT with XLO binary combination, literature survey reported their analysis via high performance liquid chromatographic (HPLC).…”

“…While for ANT with XLO binary combination, literature survey reported their analysis via high performance liquid chromatographic (HPLC). 54 Nevertheless, as far as the authors know, there is no electroanalytical method that has been applied for determination of ANT in its combination with either ANT or with XLO in different pharmaceutical formulations and biological fluid; rabbit aqueous humor.…”