Electrochemical sensing of cocaine in real samples based on electrodeposited biomimetic affinity ligands

Florea, Anca; Cowen, Todd; Piletsky, Sergey A.; Wael, Karolien De

doi:10.1039/c9an00618d

Cited by 46 publications

(24 citation statements)

References 41 publications

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“…They used p-aminobenzoic acid monomers and cocaine as template for the electro polymerization of the polymeric film onto the graphene-modified SPE. For the evaluation of the ability of the newly designed sensor to detect and quantify cocaine, square wave voltammetry (SWV) was used [ 45 ].…”

Section: Illicit Drug Detection Using Screen-printed Electrodesmentioning

confidence: 99%

Screen-Printed Electrodes (SPE) for In Vitro Diagnostic Purpose

Mincu

Lazăr

Stan³

et al. 2020

Diagnostics

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Due to rapidly spreading infectious diseases and the high incidence of other diseases such as cancer or metabolic syndrome, there is a continuous need for the development of rapid and accurate diagnosis methods. Screen-printed electrodes-based biosensors have been reported to offer reliable results, with high sensitivity and selectivity and, in some cases, low detection limits. There are a series of materials (carbon, gold, platinum, etc.) used for the manufacturing of working electrodes. Each version comes with advantages, as well as challenges for their functionalization. Thus, the aim is to review the most promising biosensors developed using screen-printed electrodes for the detection/quantification of proteins, biomarkers, or pathogenic microorganisms.

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Section: Illicit Drug Detection Using Screen-printed Electrodesmentioning

confidence: 99%

Screen-Printed Electrodes (SPE) for In Vitro Diagnostic Purpose

Mincu

Lazăr

Stan³

et al. 2020

Diagnostics

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“…The signal varied linearly with cocaine concentration in the range of 100–500 μM, with a LOD of 50 μM. The sensor was applied for the detection of cocaine in saliva and river water samples with good recoveries (Florea et al, 2019a ).…”

Section: Antibodies Aptamers and Molecularly Imprinted Polymers Formentioning

confidence: 99%

“… MIP-based sensor fabrication for the detection of cocaine. Reproduced from Florea et al ( 2019a ) with permission from the Royal Society of Chemistry. …”

Section: Antibodies Aptamers and Molecularly Imprinted Polymers Formentioning

confidence: 99%

Tackling the Problem of Sensing Commonly Abused Drugs Through Nanomaterials and (Bio)Recognition Approaches

et al. 2020

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We summarize herein the literature in the last decade, involving the use of nanomaterials and various (bio)recognition elements, such as antibodies, aptamers and molecularly imprinted polymers, for the development of sensitive and selective (bio)sensors for illicit drugs with a focus on electrochemical transduction systems. The use and abuse of illicit drugs remains an increasing challenge for worldwide authorities and, therefore, it is important to have accurate methods to detect them in seized samples, biological fluids and wastewaters. They are recently classified as the latest group of “emerging pollutants,” as their consumption has increased tremendously in recent years. Nanomaterials, antibodies, aptamers and molecularly imprinted polymers have gained much attention over the last decade in the development of (bio)sensors for a myriad of applications. The applicability of these (nano)materials, functionalized or not, has significantly increased, and are therefore highly suitable for use in the detection of drugs. Lately, such functionalized nanoscale materials have assisted in the detection of illicit drugs fingerprints, providing large surface area, functional groups and unique properties that facilitate sensitive and selective sensing. The review discusses the types of commonly abused drugs and their toxicological implications, classification of functionalized nanomaterials (graphene, carbon nanotubes), their fabrication, and their application on real samples in different fields of forensic science. Biosensors for drugs of abuse from the last decade's literature are then exemplified. It also offers insights into the prospects and challenges of bringing the functionalized nanobased technology to the end user in the laboratories or in-field.

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“…Observou-se que os limites de detecção deste trabalho são comparáveis aos valores da literatura na maioria dos casos. 111,112,114 Embora alguns artigos descrevam limites mais baixos de detecção, a metodologia utilizada neste trabalho foi baseada em um eletrodo de trabalho barato e fácil de preparar, sem modificação que ofereceu determinação de cocaína com um sistema de baixo custo, altamente reprodutível e sensível para análise de amostras apreendidas.…”

Section: Parâmetro Valores Obtidosunclassified

“…A vantagem da presente metodologia para detecção de cocaína é que não utiliza modificadores na superfície do eletrodo, como Oliveira et al 64 , Asturias-Arribas et al 87 Garrido et al 112 , Ribeiro et al 16 e Florea et al 114 Florea et al 114 utilizou eletrodo impresso modificado com grafeno, nanopartílculas de paládio e eletropolimerizado com polímeros impressos molecularmente (MIPs); que são materiais biomiméticos sintéticos projetados sob medida para ligar especificamente a molécula de interesse com alta afinidade usando ácido p-benzóico como monômero. Obtevese um limite de detecção de 5,0 10 -5 mol L -1 e comparando com a metodologia desenvolvida neste trabalho para SPE sem modificação o nosso limite de detecção obtido foi menor com o valor de 1,68 10 -5 mol L -1 .…”

Section: Parâmetro Valores Obtidosunclassified

Desenvolvimento de métodos eletroanalíticos para detecção de drogas de abuso em química forense

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Aos meus pais, Luiz e Nilda (in memoriam) pelo incentivo, compreensão, amor, e principalmente pelo companheirismo, sempre estando ao meu lado quando precisei. A vocês que, muitas vezes, renunciaram aos seus sonhos para que eu pudesse realizar o meu, partilho a alegria deste momento. Ao meu esposo, Tarcísio, por estar sempre ao meu lado, pela paciência nos momentos difíceis, pelo carinho, compreensão, amor e constante incentivo. A minha filha amada, Sofia, por todo amor incondicional e por todas as vezes que você me recebeu com um abraço apertado depois de voltar das viagens para Ribeirão Preto, isso só fortaleceu a vontade de estar sempre junto com você. À minha sogra, Neide, por estar sempre presente e por cuidar de minha filha sempre que precisei. Ao meu irmão, Júlio, pela amizade e incentivo direto ou indireto. Às minhas avós, Mitiko e Kazumi, sempre presentes em minha vida, que me incentivaram e me deram carinho para continuar seguindo em frente na constante busca pelo conhecimento. Aos meus tios, Clarice e Valdeir pelo apoio e por estarem sempre presentes. Ao Renan, por cuidar de minha filha com todo amor e carinho para que eu pudesse concluir a escrita dessa tese.

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Electrochemical sensing of cocaine in real samples based on electrodeposited biomimetic affinity ligands

Abstract: This work assesses the fabrication of the first amperometric sensor based on electropolymerized MIPs for cocaine direct detection.

Cited by 46 publications

References 41 publications

Screen-Printed Electrodes (SPE) for In Vitro Diagnostic Purpose

Screen-Printed Electrodes (SPE) for In Vitro Diagnostic Purpose

Tackling the Problem of Sensing Commonly Abused Drugs Through Nanomaterials and (Bio)Recognition Approaches

Desenvolvimento de métodos eletroanalíticos para detecção de drogas de abuso em química forense

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