Electrochemical Monitoring of DNA Hybridization by Multiwalled Carbon Nanotube Based Screen Printed Electrodes

Karadeniz, Hakan; Erdem, Arzum; Caliskan, Ayfer

doi:10.1002/elan.200804270

Cited by 52 publications

(38 citation statements)

References 43 publications

(26 reference statements)

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“…In another work of our group, the application of MWCNT-SPEs was successfully explored successfully for the electrochemical monitoring of DNA hybridization related to specific sequences on Hepatitis B virus (HBV) DNA [31].…”

Section: Introductionmentioning

confidence: 99%

Single‐Walled Carbon Nanotubes Modified Graphite Electrodes for Electrochemical Monitoring of Nucleic Acids and Biomolecular Interactions

2009

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Single-walled carbon nanotubes (SWCNT) modified disposable graphite electrodes (SWCNT-PGEs) were investigated in our study for the improved electrochemical monitoring of nucleic acids and biomolecular interactions based on the higher signal enhancement comparison to bare PGEs. The surface morphologies of bare PGE and SWCNT-PGE were firstly explored using scanning electron microscopy (SEM) analysis. The easy surface modification of disposable graphite electrodes with carbon nanotubes was performed by passive adsorption, and DNA was then immobilized onto the SWCNT-PGEs by the formation of covalent coupling between the carboxylated ends of nanotubes and the amine group in the guanine bases of DNA. The overall performance of SWCNT-PGEs has also been studied, and discussed in terms of optimum analytical conditions; such as, the effect of pretreatment step, CNT concentration, DNA concentration, etc. The reproducible detection of DNA represent a very attractive approach for the further detection of interaction between the anticancer drug, daunorubicin (DNR) and double stranded DNA (dsDNA). Voltammetric results were complemented with electrochemical impedance spectroscopy (EIS), that was used to characterize the successful construction of carbon nanotubes modification onto the surface of PGEs.

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Section: Introductionmentioning

confidence: 99%

Single‐Walled Carbon Nanotubes Modified Graphite Electrodes for Electrochemical Monitoring of Nucleic Acids and Biomolecular Interactions

2009

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“…In another work of our group, the application of commercial MWCNTSPEs was successfully explored for the electrochemical monitoring of DNA hybridization related to specific sequences on Hepatitis B virus (HBV) DNA [20].…”

Section: Introductionmentioning

confidence: 99%

Direct DNA Hybridization on the Single‐Walled Carbon Nanotubes Modified Sensors Detected by Voltammetry and Electrochemical Impedance Spectroscopy

2009

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Carboxylic acid functionalized single-walled carbon nanotubes modified graphite sensors (SWCNT-PGEs) were developed for electrochemical monitoring of direct DNA hybridization related to specific sequence of Hepatitis B virus, which substantially enhance the electrochemical transduction resulting from guanine oxidation signal comparison to bare PGEs. The performance characteristics of DNA hybridization on disposable CNT-PGE were explored measuring the guanine signal in terms of optimum analytical conditions; probe and target concentration, hybridization time, and selectivity. The voltammetric results were also complemented with electrochemical impedance spectroscopy (EIS), that was used to characterize the successful construction of carbon nanotubes modification onto the surface of PGEs.

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“…A sensitive and low cost detection of specific DNA hybridization at the surface of MWCNT modified disposable graphite electrode was performed employing a simple electrochemical protocol by Erdem et al [6]. In another work of our group, the application of MWCNT-screen printed electrodes was successfully presented for monitoring of DNA hybridization based on specific sequences on Hepatitis B virus DNA [21].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical investigation of biomolecular interactions between platinum derivatives and DNA by carbon nanotubes modified sensors

Yapasan

Caliskan

Karadeniz

et al. 2010

Materials Science and Engineering: B

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a b s t r a c tThe biomolecular interactions of platinum derivatives widely used as anticancer drugs: cisdiamminedichloroplatinum(II) and oxaliplatin with calf thymus double-stranded DNA were studied using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) in combination with single-walled carbon nanotubes modified graphite electrode (SWCNTs-GE) and unmodified graphite electrode (bare GE). The performance of these biomolecular interactions were explored at the electrode surface by monitoring the changes at guanine oxidation signal in terms of optimum interaction times by comparing the results of SWCNTs-GE with bare one. The features of these electrochemical sensors based on carbon nanotubes for monitoring of biomolecular interactions were discussed and compared with the earlier conventional ones.

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Electrochemical Monitoring of DNA Hybridization by Multiwalled Carbon Nanotube Based Screen Printed Electrodes

Cited by 52 publications

References 43 publications

Single‐Walled Carbon Nanotubes Modified Graphite Electrodes for Electrochemical Monitoring of Nucleic Acids and Biomolecular Interactions

Single‐Walled Carbon Nanotubes Modified Graphite Electrodes for Electrochemical Monitoring of Nucleic Acids and Biomolecular Interactions

Direct DNA Hybridization on the Single‐Walled Carbon Nanotubes Modified Sensors Detected by Voltammetry and Electrochemical Impedance Spectroscopy

Electrochemical investigation of biomolecular interactions between platinum derivatives and DNA by carbon nanotubes modified sensors

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