Electrochemical investigations into enzymatic polymerisation of 1,10-phenanthroline-5,6-dione as a redox mediator for lactate sensing

Halpin, Grace; Herdman, Karen; Dempsey, Eithne

doi:10.1016/j.snr.2021.100032

Cited by 8 publications

(8 citation statements)

References 18 publications

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“…Therefore, the linear range of the biosensor had become 740-2440 µM and sensitivity was 4.11×10 −4 C.cm −2 .mM −1 . Thus, the study indicated that the novel surface-con ned mediator had gained an advantage over the biosensor for lactate sensing [47]. However, with the higher sensitivity and lower limit of detection values of the biosensor, the limit of range was so high.…”

Section: Discussionmentioning

confidence: 98%

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Electrochemical detection of lactate produced by foodborne presumptive lactic acid bacteria

Özoğlu

Uzunoğlu

Ünal

et al. 2023

Journal of Bioscience and Bioengineering

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Section: Discussionmentioning

confidence: 98%

“…A lactate biosensor was fabricated using a chitosan and crosslinker con guration realized solution mediation (K 3 Fe(CN) 6 ) in the study of Halpin et al (2021). Moreover, the linear range of the biosensor was 990-5660 µM, and sensitivity was 1.44×10 −3 C.cm −2 .mM −1 .…”

Section: Discussionmentioning

confidence: 99%

Electrochemical detection of lactate produced by foodborne presumptive lactic acid bacteria

Özoğlu

Uzunoğlu

Ünal

et al. 2023

Journal of Bioscience and Bioengineering

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“…Figure 1 shows the schematic of glucose biosensors, where, in the presence of oxygen, β-D-glucose is oxidized with GOx to D-glucono-δ-lactone followed by hydrolysis in water to D-gluconic acid [ 7 ]. Nanomaterials and the redox mediator PD are used to ensure the electron transfer between the redox active site of GOx and the surface of the electrode [ 8 , 16 ]. The polymer layer can increase the stability and improve the anti-interfering ability of the glucose biosensor [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

“…Heterocyclic quinoid compounds, such as 1,10-phenanthroline-5,6-dione (PD), can act as proton and electron acceptors towards the regeneration of FAD. They are characterized by fast electron transfer kinetic, high stability in their oxidized and reduced forms, and Biosensors 2024, 14, 134 2 of 13 are suitable for the development of reagentless biosensors and biofuel cells [8,9]. In electrochemical sensors, a molecule of quinone is first reduced to a molecule of deprotonated hydroquinone and then re-oxidized at the working electrode [9].…”

Section: Introductionmentioning

confidence: 99%

Reagentless Glucose Biosensor Based on Combination of Platinum Nanostructures and Polypyrrole Layer

German,

Popov,

Ramanaviciene

2024

Biosensors

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Two types of low-cost reagentless electrochemical glucose biosensors based on graphite rod (GR) electrodes were developed. The electrodes modified with electrochemically synthesized platinum nanostructures (PtNS), 1,10-phenanthroline-5,6-dione (PD), glucose oxidase (GOx) without and with a polypyrrole (Ppy) layer—(i) GR/PtNS/PD/GOx and (ii) GR/PtNS/PD/GOx/Ppy, respectively, were prepared and tested. Glucose biosensors based on GR/PtNS/PD/GOx and GR/PtNS/PD/GOx/Ppy electrodes were characterized by the sensitivity of 10.1 and 5.31 μA/(mM cm2), linear range (LR) up to 16.5 and 39.0 mM, limit of detection (LOD) of 0.198 and 0.561 mM, good reproducibility, and storage stability. The developed glucose biosensors based on GR/PtNS/PD/GOx/Ppy electrodes showed exceptional resistance to interfering compounds and proved to be highly efficient for the determination of glucose levels in blood serum.

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“…36−38 In this study, 1,10-phenathroline-5,6-dione (PD), a N−N chelate ligand containing an o-quinoid moiety, was used as a versatile redox mediator. 39 Conventional lithographic techniques are well utilized for realizing soft microfluidic channels, but the method is expensive and depends on multistage complex processes. The use of a simple and low-cost method for realizing microfluidic master could facilitate high throughput production of wearable microfluidic sensors.…”

Section: ■ Introductionmentioning

confidence: 99%

A Neckband-Integrated Soft Microfluidic Biosensor for Sweat Glucose Monitoring

Mwaurah,

Vinoth,

Nakagawa

et al. 2024

ACS Appl. Nano Mater.

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A neckband-integrated soft microfluidic biosensor was developed for real-time glucose monitoring in sweat. Flexible screen-printed electrodes were prepared and utilized for developing oxidase enzyme-based amperometric sensors. The electrochemical oxidation of glucose was catalyzed and mediated by bimetallic palladium and platinum-supported reduced graphene oxide and 1,10-phenanthroline-5,6-dione, respectively. Soft, microfluidic channels were prepared by developing clean-room free, 3D-printed master and integrated with the flexible sensors. The fluidic channel provides autonomous capillary flow of liquids through the sensor surface and facilitates real-time detection. The fluid flow analysis demonstrated homogeneous filling of the sensing chamber and the outlets within 8s. The developed biosensor showed good selectivity, sensitivity, and stability toward glucose in phosphate buffer solution as well as in human sweat samples. The sensor showed linear amperometric responses for glucose at 0.2 V ranging from 50 to 900 μM with a limit of detection of 37 μM and sensitivity of 30 μA cm −2 mM −1 . For real-life application, the pump-less microfluidic sensor was mounted on a 3D-printed neckband and coupled with a Bluetooth-enabled miniature potentiostat for wireless sweat glucose analysis. The real-time sweat glucose monitoring at the fasting stage and after spiking with glucose-rich meal showed good correlation with corresponding capillary blood glucose readings with a Pearson correlation coefficient of 0.87. Further, the sensor performances have been successfully validated by high-performance liquid chromatography. The presented wearable sensor offers facile noninvasive measurement of glucose levels from exercise-induced sweat samples for personalized diabetes monitoring.

show abstract

Electrochemical investigations into enzymatic polymerisation of 1,10-phenanthroline-5,6-dione as a redox mediator for lactate sensing

Cited by 8 publications

References 18 publications

Electrochemical detection of lactate produced by foodborne presumptive lactic acid bacteria

Electrochemical detection of lactate produced by foodborne presumptive lactic acid bacteria

Reagentless Glucose Biosensor Based on Combination of Platinum Nanostructures and Polypyrrole Layer

A Neckband-Integrated Soft Microfluidic Biosensor for Sweat Glucose Monitoring

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