Electrochemical determination of sertraline in pharmaceutical formulation and serum using a gold electrode in a pH 8.4 bicarbonate solution

Abstract

The electrochemical characterization of sertraline at gold electrode was examined by cyclic voltammetry measurements (CV) in pH 8.4 bicarbonate buffer. Then Au electrode was evaluated for the quantitative determination of sertraline using square wave voltammetry (SWV). To enhance the sensitivity during the drug determination, (2-hydroxypropyl)-β-cyclodextrin (HPβCD) and β-cyclodextrin (βCD) inclusion complexes were employed. Using the proposed SWV technique, the anodic current peak was linear within a concentration range of 0.1-0.5 µM with a limit of detection (LOD) of 2.0 × 10 -8 M and a limit of quantification (LOQ) of 6.7 × 10 -8 M. In the case of inclusion complex of the sertraline with HPβCD, a good linearity range of 0.1-0.9 µM was obtained with a LOD of 2.6 × 10 -8 M and a LOQ of 8.8 × 10 -8 M. The gold electrode revealed the same linearity range for inclusion complex of the sertraline with βCD with a LOD and a LOQ being 2.6 × 10 -8 and 8.6 × 10 -8 M, respectively. Comparing the regression equations, it can be concluded that the sensitivity in the presence of inclusion complex can be up to 5 times higher. The applicability of the developed method was confirmed by the analysis of this drug in pharmaceutical formulation and in human serum spiked with sertraline standard. The comparison to HPLC method was successfully performed.

Review on Surface-Modified Electrodes for the Enhanced Electrochemical Detection of Selective Serotonin Reuptake Inhibitors (SSRIs)

“…Cyclodextrins were able to enhance the bioavailability of sertraline, by increasing its solubility. Regression equations concluded a sensitivity five times higher in the presence of inclusion complexes of cyclodextrin [ 44 ]. Table 1 summarises polymer-based, surface modified electrodes and the analytical techniques used for the detection of various SSRIs, their linear range, and limits of detection, potential interference and application samples.…”

Thermodynamic Studies of Interactions between Sertraline Hydrochloride and Randomly Methylated β-Cyclodextrin Molecules Supported by Circular Dichroism Spectroscopy and Molecular Docking Results

“…Lately, the interactions between antidepressant drugs and cyclodextrins were examined [22][23][24][25][26], mostly in order to gain the better water solubility of the drug [27][28][29], or to decrease its toxicity [30,31] or even for taste-masking [32]. One of the antidepressants, sertraline hydrochloride, belonging to the class of selective serotonin reuptake inhibitors (SSRIs) [33,34] and also tested as potential anti-Helicobacter pylori compound [35] has already been tested in the presence of β-cyclodextrin and the derivatives [36][37][38][39][40] inter alia in our laboratory [31,41,42].…”