Electrochemical deposition of dopamine–hyaluronic acid conjugates for anti-biofouling bioelectrodes

Kim, Semin; Jang, Yohan; Jang, Lindy K.; Sunwoo, Sung; Kim, Tae Il; Cho, Seung Woo; Lee, Jae Young

doi:10.1039/c7tb00028f

Cited by 33 publications

(25 citation statements)

References 36 publications

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“…Combination of ultrasound and electric pulses with HA microneedle dissolution in hydrogel. Figure 1a schematically illustrates the dissolution of hyaluronic acid (HA) microneedles, which are water-soluble polymers of disaccharides, in the body [35][36][37][38] . The optically transparent gelatin hydrogel was used as a tissue model, making it easy to observe the dissolution of HA microneedles.…”

Section: Resultsmentioning

confidence: 99%

“…To date, a multi-strategy approach to transdermal delivery in dissolving microneedles has been rare. HA, which is the major component of the dissolving microneedle, is a natural water-soluble polymer with excellent biocompatibility [35][36][37][38] and enables dissolution of the microneedles. HA is a binding agent approved by the US food and Drug Administration (FDA) and is widely used in the beauty and healthcare industry 35,37 .…”

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confidence: 99%

“…To enhance transdermal transport, 1.7 MHz ultrasound was used, and frequency and voltage dependencies were evaluated for alternating IP. HA is biopolymer with negatively charged ions [36][37][38] , and rhodamine B was used as a positively charged drug model 39,40 . The difference in the release of rhodamine was analyzed, and the fluxes were compared in terms of transport.…”

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confidence: 99%

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Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches

Bok

Zhao

Jeon

et al. 2020

Sci Rep

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A multifunctional system comprised of hyaluronic acid microneedles was developed as an effective transdermal delivery platform for rapid local delivery. The microneedles can regulate the filling amount on the tip, by controlling the concentration of hyaluronic acid solution. Ultrasonication induces dissolution of the HA microneedles via vibration of acoustic pressure, and AC iontophoresis improves the electrostatic force-driven diffusion of HA ions and rhodamine B. The effect of ultrasound on rhodamine release was analyzed in vitro using a gelatin hydrogel. the frequency and voltage dependence of the Ac on the ion induction transfer was also evaluated experimentally. the results showed that the permeability of the material acts as a key material property. The delivery system based on ultrasonication and iontophoresis in microneedles increases permeation, thus resulting in shorter initial delivery time than that required by delivery systems based on passive or ultrasonication alone. This study highlights the significance of the combination between ultrasonic waves and iontophoresis for improving the efficiency of the microneedles, by shortening the reaction duration. We anticipate that this system can be extended to macromolecular and dependence delivery, based on drug response time.

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Section: Resultsmentioning

confidence: 99%

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Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches

Bok

Zhao

Jeon

et al. 2020

Sci Rep

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“…This was perhaps due to its hydrophilicity that reduced protein adsorption. [34,35] Additionally, a lot of linear PEG chains on the PEGylated PSANMs resisted protein adsorption due to large steric repulsion. [33] As shown in Figure 3B, the total proteins on PSANMs-g-PEG 5 kDa remarkably decreased, which protein adsorption reduced by 20 %~83 % compared with the PSANMs (Table S2), indicating that PEG modification effectively improved anti-biofouling ability of the PSANMs.…”

Section: Anti-biofouling Effect Of Pegylated Psanmsmentioning

confidence: 99%

Hydrophilic Porous Poly(l‐Lactic Acid) Nanomembranes: Self‐Assembly, and Anti‐Biofouling and Anti‐Thrombosis Effects

et al. 2019

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Hydrophilic PEGylated porous self‐assembled nanomembranes (PSANMs) with average thickness and pore diameter of ca. 10 and 20–24 nm were successfully prepared by an emulsification‐induced programmable self‐assembly strategy. The hydrophilicity, anti‐biofouling, and anti‐thrombosis properties of PEGylated PSANMs were largely improved in comparison with the nonfunctionalized PSANMs, which could transform into hydrophilic (PEGylated PSANMs, minimum water contact angle: 38.8°) from hydrophobic units (PSANMs, maximum water contact angle: 137.5°) with increasing PEG density and length. The total protein adsorption of PEGylated PSANMs was about six times lower than that of the PSANMs, while the thrombosis of the PEGylated PSANMs (maximum R‐time: 5.37 min) was also greatly relieved in comparison with the PSANMs (minimum R‐time: 2.93 min). Such PEG‐modified PSANMs may have applications in drug delivery and tissue and organ repair in vivo.

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“…23,28,29 Moreover, the elastomer matrix provides independent control of the elastic property of the entire coating, an attribute that has been shown to be important for FR performance. [30][31][32] The most environmentally benign FR coatings currently commercialized are those based on PDMS elastomers. 20 Combinations of those prerequisite features into effective antibiofouling polymer systems in many cases are achieved by complex chemical platforms that involve for example, sequential polymerizations of specifically synthesized monomers and series of polymer-analogue modifications of preformed polymers.…”

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confidence: 99%

Amphiphilic pentablock copolymers and their blends with PDMS for antibiofouling coatings

Martinelli

Guazzelli

Bartoli

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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Well-defined amphiphilic pentablock copolymers Siy-(EGx-FAz) 2 composed of polysiloxane (Si), polyethylene glycol (EG), and perfluorohexylethyl polyacrylate (FA) blocks are synthesized by ATRP of FA monomer starting from a difunctional bromo-terminated macroinitiator. Diblock copolymers EGx-FAz are also synthesized as model systems. The block copolymers are used, either alone or blended with a PDMS matrix in varied loadings, to prepare antibiofouling coatings. Angle-resolved XPS and contact angle measurements show that the coating surface is highly enriched in fluorine content but undergoes reconstruction after contact with water.Protein adsorption experiments with human serum albumin and calf serum highlight that diblock copolymers resist protein adhesion better than do pentablock copolymers. Blending of the pentablock copolymer with PDMS results in increased protein adsorption. By contrast, the PDMS-matrix coatings show high removal percentages of sporelings of the green fouling alga Ulva linza. V C 2015 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 000: 000-000, 2015

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Electrochemical deposition of dopamine–hyaluronic acid conjugates for anti-biofouling bioelectrodes

Abstract: Electrochemical deposition of dopamine-hyaluronic acid conjugates onto electrode surfaces can lead to preserved electrochemical activities and anti-biofouling properties of the electrodes.

Cited by 33 publications

References 36 publications

Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches

Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches

Hydrophilic Porous Poly(l‐Lactic Acid) Nanomembranes: Self‐Assembly, and Anti‐Biofouling and Anti‐Thrombosis Effects

Amphiphilic pentablock copolymers and their blends with PDMS for antibiofouling coatings

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