Electrochemical characterization of cefadroxil β-lactam antibiotic and Cu(II) complex formation

Sanz, Caroline G.; Serrano, Sı́lvia Helena Pires; Brett, Christopher M.A.

doi:10.1016/j.jelechem.2019.04.077

Cited by 14 publications

(10 citation statements)

References 41 publications

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“…The slope of the plot of E pa versus pH for CLN and CFL was 0.04 and 0.05 V/pH, respectively, showing the involvement of an equal number of electrons and protons. 14 , 18 Moreover, the oxidative peak current of CLN and CFL at the surface of the poly(reso)/GCE increased with pH value from pH 4.0 to 6.0 and then decreased beyond 6.0 (curve a of Figure 5 B and C). Therefore, pH 6.0 was chosen as the optimum value for the next experiments.…”

Section: Resultsmentioning

confidence: 95%

“… 14 , 15 On the other hand, owing to their simplicity, low cost, reproducibility, high sensitivity, fast analytical responses, and environmental friendliness, electrochemical techniques are more appealing than conventional ones. 14 , 15 …”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, all these methods need tedious sample preparation, are time-consuming, require complex analytical equipment, and are non-ecofriendly. 14,15 On the other hand, owing to their simplicity, low cost, reproducibility, high sensitivity, fast analytical responses, and environmental friend- liness, electrochemical techniques are more appealing than conventional ones. 14,15 Resorcinol (1,3-dihydroxybenzene) (Scheme S2) is ascribed as one of the azo-dyes, which has two hydroxyl groups available for coordination and electropolymerization.…”

Section: Introductionmentioning

confidence: 99%

“…14,15 On the other hand, owing to their simplicity, low cost, reproducibility, high sensitivity, fast analytical responses, and environmental friend- liness, electrochemical techniques are more appealing than conventional ones. 14,15 Resorcinol (1,3-dihydroxybenzene) (Scheme S2) is ascribed as one of the azo-dyes, which has two hydroxyl groups available for coordination and electropolymerization. 16 Attempts have been made for application of voltammetric methods for determining CLN and CFL separately in different real samples.…”

Section: Introductionmentioning

confidence: 99%

“…Spectrophotometry, , chromatography, , and hyphenated methods , are among the common techniques reported for the determination of CLN and CFL individually in different samples. Unfortunately, all these methods need tedious sample preparation, are time-consuming, require complex analytical equipment, and are non-ecofriendly. , On the other hand, owing to their simplicity, low cost, reproducibility, high sensitivity, fast analytical responses, and environmental friendliness, electrochemical techniques are more appealing than conventional ones. , …”

Section: Introductionmentioning

confidence: 99%

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Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

et al. 2022

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This study covers the development of a fast, selective, sensitive, and stable method for the simultaneous determination of cephalosporins (cephalexin (CLN) and cefadroxil (CFL)) in biological fluids and tablet samples using potentiodynamic fabrication of a poly(resorcinol)-modified glassy carbon electrode (poly(reso)/GCE). The results of cyclic voltammetry and electrochemical impedance spectroscopy supported the modification of the GCE by a polymer layer that raised the electrode surface area and conductivity. At the poly(reso)/GCE, an irreversible oxidative peak with four- and fivefold current enhancement for CLN and CFL, respectively, at a substantially lower potential demonstrated the catalytic action of the modifier. Under optimized solution and parameters, the peak current response at the poly(reso)/GCE revealed a linear dependence on the concentration of CLN and CFL within the range 0.1–300 and 0.5–300 μM, respectively, with a limit of detection (LoD) of 3.12 and 8.7 nM, respectively. The levels of CLN in four selected tablet brands and CFL in two tablet brands were in the vicinity of 91.00–103.65% and 97.7–98.83%, respectively, of their nominal values. The recovery results for CLN in pharmaceutical samples were in the range of 99.00–100.67% and for CFL 97.9–99.75% and for blood serum and urine samples 99.55–100.55% and 99.33–100.34% for CLN and 97.13–100.60% and 96.73–102.50% for CFL, respectively. Interference recovery results with errors less than 4.81%, lower LoD, wider dynamic range, excellent recovery results, and good stability of the modifier compared to those for the previously reported methods validated the use of the poly(reso)/GCE for determining CLN and CFL simultaneously in various real samples.

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

et al. 2022

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Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

2020

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The electrochemical characterization and determination of the antibiotic cefadroxil were carried out at multi-walled carbon nanotube (CNT) and gold nanoparticle (AuNP) modified glassy carbon electrodes (GCE). Oxidation of the phenol moiety of cefadroxil occurred at slightly less-positive potentials and with a higher current response than at bare GCE. Differential pulse voltammetry and electrochemical impedance spectroscopy showed that the architecture combining CNT and AuNP surface modification is the best in pH 7 buffer solution. Scanning electron microscopy demonstrated good coverage of the AuNPs on the CNTs. The fixed potential amperometric determination of cefadroxil was carried out at + 0.74 V vs Ag/AgCl with a limit of detection of 0.22 μM. Analysis of cefadroxil in commercial samples presented high recovery values and the amount of the pharmaceutical in each capsule was in excellent agreement with that measured by UV/Vis spectroscopy.

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Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu²⁺ Complex and its Analytical Applications

et al. 2021

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The interaction of cefoxitin, being a compound of interest for antibiotic research, with Cu 2 + resulted in the formation of a 1 : 1 complex. The electrochemical reduction at a hanging mercury drop electrode and oxidation at a renewable pencil graphite electrode of the formed cefoxitin-Cu 2 + complex was investigated using cyclic voltammetry and differential pulse voltammetry in Britton-Robinson buffers (pH 2-9). For the electrochemical reduction or oxidation of the examined complex, a new well-defined voltammetric peak was obtained and the features of the surface redox and oxidation peaks were studied. Calculations of the values of stability constant and the change on Gibbs free energy for cefoxitin-Cu 2 + complex suggest that the complexation is a spontaneous process. The sharp peak of the electroreduction and oxidation of the investigated complex associated with an effective interfacial accumulation of this complex facilitates the determination of the antibacterial drug cefoxitin in the bulk and blood serum samples. Cefoxitin was determined by electrochemical reduction and oxidation of the cefoxitin-Cu 2 + complex, with detection limits of 6.94 × 10 À 9 M and 9.07 × 10 À 8 M respectively.

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Electrochemical characterization of cefadroxil β-lactam antibiotic and Cu(II) complex formation

Cited by 14 publications

References 41 publications

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu²⁺ Complex and its Analytical Applications

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Electrochemical characterization of cefadroxil β-lactam antibiotic and Cu(II) complex formation

Cited by 14 publications

References 41 publications

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu2+ Complex and its Analytical Applications

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Electrochemical Reduction and Oxidation of the Antibiotic Cefoxitin‐Cu²⁺ Complex and its Analytical Applications