Electrochemical aptasensor for mucin 1 based on dual signal amplification of poly(o-phenylenediamine) carrier and functionalized carbon nanotubes tracing tag

Voltammetric aptasensors for protein disease biomarkers detection: A review

“…This "signal-on" aptasensor exhibited good linear correlation dynamic ranges from 8.8 nM to 353.3 nM and a very low detection limit (2.2 nM). Likewise, Chen et al (2015) also reported a signal-on electrochemical aptasensor for the same protein. The poly(o-phenylenediamine)-AuNPs (PoPDAuNPs) film was used as capture probe for the immobilization of aptamer-1.…”

“…Metal nanoparticles (e.g. AuPNs, AgNPs, PtNPs), silica nanoparticles (Si NPs), QDs, magnetic nanoparticles (MNPs), carbon nanotubes (CNTs), graphene (GNs) and their nanocomposites have been used for the development of electrochemical biosensors (Bai et al, 2012;Cao et al, 2014;Chen et al, 2015;Deng et al, 2013b;Hu et al, 2014;Jo et al, 2015;Li et al, 2011b;Ravalli et al, 2015;Wang et al, 2011;Zhao et al, 2011a) These nanomaterials have unique physical and chemical properties and can be used in several electrode surfaces such as GCE (Ding et al, 2010;Li et al, 2011b) and SPE (Suprun et al, 2008) in a variety of applications. For electrochemical applications, these nanomaterials allowed an easy functionalization of the electrode surfaces, namely an increase of the surface area for the aptamers attachment onto the electrode surfaces, therefore facilitating the access of the target molecule to these aptamers, and acting as electrochemical labels by increasing the signal amplification or electron-transfer mediators (Citartan et al, 2012;Erdem et al, 2009;Hernandez and Ozalp, 2012;Palchetti and Mascini, 2012;Vidotti et al, 2011;Vikesland and Wigginton, 2010;Wang et al, 2015).…”

Application of electrochemical aptasensors in detection of cancer biomarkers

“…Aptasensors are kinds of biosensors that aptamers (DNA or RNA oligonucleotide sequences in a single strand status) act as the biorecognition element in their structure 34,35 . Given that the used aptamers in aptasensors are synthetic, the affinity and specificity of aptasensors towards the analytes can be controlled and enhanced 36,37 . Aptasensors can detect analytes in very small amounts where these minimalistic amounts are not detectable with most of the other existing methods 38,39 ; in addition, the low cost for designing the aptasensors compared to other cancer diagnostics methods should be considered as one of the economic savings 40,41 .…”

“…Ther. ; 6(7):3315-3324. diagnostic techniques are low detection time and fast detection process 34,36,39,40,42 . In this review, the applications of aptasensors in order to the diagnosis of cancer biomarkers were collected and reviewed from related researches.…”

A highly sensitive metronidazole sensor based on a Pt nanospheres/polyfurfural film modified electrode

“…[34][35][36][37][38][39][40][41] In particular, the strategy of electropolymerization is to immobilize a polymer lm onto an electrode surface with multiple active sites and advantages of rapid synthesis, controllable lm thickness, exible charge transport and permeation characteristics by easily adjusting the electrochemical parameters. 42,43 Previously, we have successfully prepared a polyfurfural lm modied glassy carbon electrode (GCE) by a one-step electropolymerization , which exhibits excellent electrocatalytical activity to the reduction of the nitro group in hexatomic aromatic compounds 44,45 due to the promoted electron transfer by the conjugated p-electron backbones of polyfurfural lm. [44][45][46] Herein, we seek the possibility of the polyfurfural lm for the catalytical reduction of the nitro group in a pentatomic cyclic compound of metronidazole.…”