A highly sensitive metronidazole sensor based on a Pt nanospheres/polyfurfural film modified electrode

Huang, Jianzhi; Shen, Xiaolei; Wang, Ruili; Zeng, Qiang; Wang, Lishi

doi:10.1039/c6ra25106d

Cited by 50 publications

(16 citation statements)

References 57 publications

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“…As it can be concluded from Table 4, the proposed electrochemical sensor is superior in almost every aspect to most of those ever fabricated. [38][39][40][41][42][43] This might be attributed to the application of the MIP/GNW/rGO hybrid nanocomposite on the SPCE electrode.…”

Section: Determination Of Mtzmentioning

confidence: 99%

Developing a Novel Nanocomposite of Gold Nanowires/Reduced Graphene Oxide/Molecularly Imprinted Polyaniline for the Electrochemical Sensing of Metronidazole

Dehghani

Nasirizadeh

Yazdanshenas

2019

J Apple Biotechnol Rep

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Introduction Metronidazole (MTZ: 1 beta-hydroxyethyl-2-methyl-5nitromidazole), as a synthetic antibiotic belonging to the nitroimidazole class, is an antibacterial and anti-protozoal agent. 1 It is most widely used to treat infectious diseases caused by anaerobic bacteria and protozoa. 2 However, due to its ring structure, it can cause carcinogenic, teratogenic, mutagenic and genetic toxicities to humans. 3-5 Therefore, it is very important to develop highly sensitive and rapid methods for MTZ determination. For this purpose, a variety of analytical methods have been used so far, including different versions of high-performance liquid chromatography and ultra-performance liquid chromatography, 6-9 thin layer chromatography, 10,11 gas chromatography, 12,13 and spectrophotometry. 14,15 The above-mentioned methods suffer from technical problems in drug separation and detection, such as being costly and time-consuming and needing large amounts of samples. Most importantly, separation of MTZ by those techniques needs purification and pre-concentration. In this context, electrochemical methods prove to be of benefit due to their low cost, simple operation, fast response, and ease of handling. 16-18 Many researchers have reported that modification of electrodes by using nanoparticles and molecularly imprinted polymers (MIPs) is a key step to design, fabricate, and operate sensors and biosensors. 18-20 Nanomaterials can improve the sensitivity of nanosensors by enhancing the electron transfer rate and expanding the actual surface area of electrodes. 21-23 In addition, MIPs have advantages such as simplicity, low cost and high selectivity. At the same time, unlike other materials, they are effective even for ultra-trace quantities. 24,25 The MIP electrochemical sensors can be made in a variety of ways including bulk polymerization, sol-gel process,

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Section: Determination Of Mtzmentioning

confidence: 99%

Developing a Novel Nanocomposite of Gold Nanowires/Reduced Graphene Oxide/Molecularly Imprinted Polyaniline for the Electrochemical Sensing of Metronidazole

Dehghani

Nasirizadeh

Yazdanshenas

2019

J Apple Biotechnol Rep

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“…The reduction peak potentials (E pc ) shift negatively with the increment of pH values of PBS, manifesting the protons are involved in electroreduction of metronidazole. [19] Furthermore, because the peak current is largest, pH = 7.5 will be chosen as the optimal pH value, just as shown in inset of Figure 5 (curve b). Obviously, the slope is À56.6 mV pH À1 .…”

Section: The Electrochemical Research Of Metronidazolementioning

confidence: 99%

“…[18] Up to date, there are several works to monitor metronidazole by electrochemical detection approaches, such as noble metal nanoparticles [19] and molecularly imprinted polymer [20] based electrochemical sensors. Metronidazole, an oral drug that pertains to a class of nitroimidazole derivative, is crucial to treat anaerobic bacterial diseases and protozoal diseases.…”

Section: Introductionmentioning

confidence: 99%

High Performance Electrocatalyst Based on MIL‐101(Cr)/Reduced Graphene Oxide Composite: Facile Synthesis and Electrochemical Detections

Yin

et al. 2018

ChemElectroChem

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In this work, a Cr-based MOF (MIL-101(Cr))/reduced grapheme oxide(rGO) electrocatalyst was prepared through a one-pot hydrothermal method. The obtained composite was characterized via scanning electron microscopy, transmission electron microscopy, X-ray diffraction and other standard techniques. Electrochemical methods were adopted to study the electrocatalytic ability of the composite. The results imply that, compared to the single components, it exhibits higher electrocatalytic activity for the reduction of metronidazole and stripping of Cd 2 + and Pb 2 + . Optimizing the ratio of MIL-101(Cr) and rGO, an electrochemical sensor was prepared using MIL-101 (Cr)/rGO-20 and used for detection of metronidazole, Cd 2 + and Pb 2 + , respectively. The linear range for metronidazole can be divided in two parts, i. e. from 0.5 to 200 mM and from 200 to 900 mM. The limit of detection is 0.24 mM (S/N = 3, n = 10). Likewise, it also exhibits a wide linear range from 0.05 to 6.0 mM for the detection of Cd 2 + and Pb 2 + . The corresponding detection limits are found to be 5.2 nM and 3.0 nM (S/N = 3, n = 10), respectively. The proposed sensor also possesses superb selectivity, reproducibility, stability and can be applied to detect real samples with desired recovery rates. In addition, the possible reduction mechanism of metronidazole and adsorption mechanism of Cd 2 + and Pb 2 + were further discussed simply in this work.[a] J.

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“…1 It has been widely used for antiprotozoal, antiamebic and antibacterial drugs, and is generally effective in the treatment of trichomoniasis, giardiasis, and amoebiasis diseases. [2][3][4] It has also been added to sh and poultry feed to eliminate parasites 5 or promote weight gain. 6,7 Due to its low price and efficient treatment of bacterial infections, many commercial companies still illegally use MNZ as an additive in cosmetic materials.…”

Section: Introductionmentioning

confidence: 99%

Carbon quantum dots as a fluorophore for “inner filter effect” detection of metronidazole in pharmaceutical preparations

et al. 2019

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A highly sensitive metronidazole sensor based on a Pt nanospheres/polyfurfural film modified electrode

Abstract: A sensitively electrochemical metronidazole sensor basing on a Pt nanospheres/polyfurfural modified glassy carbon electrode.

Cited by 50 publications

References 57 publications

Developing a Novel Nanocomposite of Gold Nanowires/Reduced Graphene Oxide/Molecularly Imprinted Polyaniline for the Electrochemical Sensing of Metronidazole

Developing a Novel Nanocomposite of Gold Nanowires/Reduced Graphene Oxide/Molecularly Imprinted Polyaniline for the Electrochemical Sensing of Metronidazole

High Performance Electrocatalyst Based on MIL‐101(Cr)/Reduced Graphene Oxide Composite: Facile Synthesis and Electrochemical Detections

Carbon quantum dots as a fluorophore for “inner filter effect” detection of metronidazole in pharmaceutical preparations

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