Carbon quantum dots as a fluorophore for “inner filter effect” detection of metronidazole in pharmaceutical preparations

Tang, Jianghong; Zhang, Yaheng; Liu, Yuhai; Liú, Dan; Qin, Hengfei; Lian, Ning

doi:10.1039/c9ra08477k

Cited by 27 publications

(15 citation statements)

References 54 publications

(66 reference statements)

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“…It has been previously reported by Devi et al that the JM complex (TNT-NH 2 ) shows the absorption in wavelength ranging from 400 to 550 nm [4,30]. Therefore, the possible spectral overlap between the fluorescence emission spectrum of the IRMOF-3 particles and the absorption spectrum of the JM complex is expected to result in this energy transfer, i.e., IFE [4,30,31].…”

Section: Selectivity and Interference Studymentioning

confidence: 93%

Nitrogen-doped carbon quantum dots conjugated isoreticular metal-organic framework-3 particles based luminescent probe for selective sensing of trinitrotoluene explosive

et al. 2020

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Amine group-containing isoreticular metal-organic framework (IRMOF-3) particles are utilized for the first time as a trinitrotoluene (TNT) sensing material. IRMOF-3 particles are synthesized using zinc nitrate as a metal precursor and 2-amino-1,4benzenedicarboxylic acid as a linker. The nitrogen-doped carbon quantum dots (NCQDs) are synthesized from citric acid and ethylenediamine as carbon and nitrogen precursor, respectively. The NCQDs are conjugated with IRMOF-3 particles as IRMOF-3/NCQDs. The TEM micrograph revealed the average size of IRMOF-3 particles to be 363.66 nm. The photoluminescence emission intensity of IRMOF-3 particles at λ em 430 nm is highly increased in the presence of NCQDs (λ ex 330 nm). Both the assynthesized IRMOF-3 and IRMOF-3/NCQD particles are explored for TNT detection to compare the effect of NCQDs on the IRMOF-3 particle surface. Lower limit of detection (7.5 × 10 −8 M) and higher Stern-Volmer constant (4.46 × 10 6 M −1 ) are achieved by IRMOF-3/NCQD particles. The association constant also increased from 5.3 × 10 4 to 2.78 × 10 6 M −1 after the conjugation of IRMOF-3 particles with NCQDs. Moreover, enhanced selectivity for TNT over trinitrophenol is achieved using the IRMOF-3/NCQD particles.

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Section: Selectivity and Interference Studymentioning

confidence: 93%

Nitrogen-doped carbon quantum dots conjugated isoreticular metal-organic framework-3 particles based luminescent probe for selective sensing of trinitrotoluene explosive

et al. 2020

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“…It is noteworthy that the uorescent probe of this method uses natural biomass as carbon source and adopts one-step hydrothermal method, which is simpler and more environmentally friendly. FCNs Hydrothermal method gardenia 0.8 -225 0.28 [31] CDs Solvent hot method H. cordata 3.3-240 0.12 [32] Cu/NCQDs Hydrothermal method frangipani 0-350 0.28 work…”

Section: Analysis and Test Of Actual Samplesmentioning

confidence: 99%

Synthesis of copper–nitrogen codoped carbon quantum dots using frangipani as a carbon source and application of metronidazole determination

et al. 2022

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High-uorescence Cu/N codoped carbon quantum dots (Cu/NCQDs) were prepared by a one-step hydrothermal method using frangipani as the carbon source and copper acetate as the copper source. The Cu/NCQDs exhibited high-intensity, stable blue uorescence that is independent of the excitation wavelength. Since metronidazole can effectively quench the uorescence intensity of Cu/NCQDs, a metronidazole uorescence-detection method using Cu/NCQDs as the uorescence probe was developed, and the quenching mechanism was studied.The method has the advantages of simplicity, speed, and low cost. Besides,it has a wider linear range and detection limit. Further, the metronidazole content in actual samples was determined by this method, with good results. Statement Of NoveltyCarbon quantum dots (QDS) are uorescent carbon nanomaterials with dual advantages of both uorescent materials and nanomaterials, so they have been widely studied. In recent years, developing the concept of "green chemistry" to synthesize green carbon quantum dots has become a research hotspot, and more green carbon materials and simple and e cient synthesis methods need to be developed. Meanwhile, heteroatomic doped carbon quantum dots (QDS) have attracted much attention because of their novel optical properties, which are different from pure carbon dots. There are many researches on the doping of non-metallic elements with carbon quantum dots, but there are few reports on the doping of metallic elements, especially transition metal elements, and there is a great space for development. Based on the above research background, a one-step hydrothermal process was used to process natural biomass to obtain transition metal codoped carbon quantum dots.

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“… Analyte Method Matrix Linearity range LOD Refs. MNZ Extractional spectrophotometry Pure and dosage forms 2.50–22.50 µg/mL 5.33 × 10 −2 µg/mL 9 UV-spectrophotometry Pure and dosage forms 2.0–16.0 µg/mL – 12 RP-HPLC Pure and dosage forms 0.10–0.30 mg/mL – 22 Flow injection analysis Pure and dosage forms 2.0–20.0 mg/L 0.7 mg/L 29 Capillary electrophoresis Porcine muscle samples 5.00–300.0 µg/kg 0.5 µg/kg 32 Spectrofluorimetry (N-CDs were synthesized by a microwave-assisted method) Real milk samples 0.5–22.0 µM 0.22 µM 15 Spectrofluorimetry (CDs were synthesized by a hydrothermal technique) Pure and dosage forms 3.3 × 10 −6 —2.4 × 10 −4 M 1.2 × 10 −7 M 18 ONZ Extractional spectrophotometry Pure and dosage forms 7.50–35.0 µg/mL 5.01 × 10 –2 µg/mL 9 Spectrophotometry Pure and dosage forms …”

Section: Introductionmentioning

confidence: 99%

“…Several methods for analysis of MNZ, TNZ and/or ONZ in bulk and dosage forms, as-well-as-biological-fluids, have been published. These methods include-spectrophotometry [9][10][11][12][13][14] , spectrofluorimetry [15][16][17][18][19] , HPLC [20][21][22] , electrochemistry [23][24][25][26][27] , non-aqueous titration 28 , flow injection analysis 29 , capillary electrophoresis [30][31][32] , and gas chromatography 33 .…”

mentioning

confidence: 99%

Sulfur and nitrogen co-doped carbon quantum dots as fluorescent probes for the determination of some pharmaceutically-important nitro compounds

Magdy

Ebrahim

Belal

et al. 2023

Sci Rep

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In this study, highly fluorescent sulfur and nitrogen co-doped carbon quantum dots (SN-CQDs) were synthesized by a simple one-pot hydrothermal method using thiosemicarbazide and citric acid as starting materials. Various spectroscopic and microscopic techniques were applied to characterize the prepared SN-CQDs. The synthesized SN-CQDs’ maximum fluorescence emission was obtained at 430 nm after excitation at 360 nm. Rifampicin (RFP), tinidazole (TNZ), ornidazole (ONZ), and metronidazole (MNZ) all quantitatively and selectively quenched the SN-CQDs’ native fluorescence, which was the base-for their-spectrofluorimetric estimation without the need for any tedious pre-treatment steps or high-cost instrumentation. SN-CQDs demonstrated a “turn-off” fluorescence response to RFP, TNZ, ONZ, and MNZ over the ranges of 1.0–30.0, 10.0–200.0, 6.0–200.0, and 5.0–100.0 μM with detection limits of 0.31, 1.76, 0.57, and 0.75 μM and quantitation limits of 0.93, 5.32, 1.74, and 2.28 μM respectively. The suggested method was successfully used to determine the investigated drugs in their commercial dosage forms. The method was further extended to their determination in spiked human plasma samples, with satisfactory mean % recoveries (99.44–100.29) and low % RSD values (< 4.52). The mechanism of fluorescence quenching was studied and discussed. The suggested method was validated in accordance with ICH recommendations.

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Carbon quantum dots as a fluorophore for “inner filter effect” detection of metronidazole in pharmaceutical preparations

Abstract: CDs were prepared using Houttuynia cordata via hydrothermal process, the absorption band of MNZ can well overlap the excitation bands of CDs, a simple, rapid approach for detection of MNZ was established on the basis of IFE.

Cited by 27 publications

References 54 publications

Nitrogen-doped carbon quantum dots conjugated isoreticular metal-organic framework-3 particles based luminescent probe for selective sensing of trinitrotoluene explosive

Nitrogen-doped carbon quantum dots conjugated isoreticular metal-organic framework-3 particles based luminescent probe for selective sensing of trinitrotoluene explosive

Synthesis of copper–nitrogen codoped carbon quantum dots using frangipani as a carbon source and application of metronidazole determination

Sulfur and nitrogen co-doped carbon quantum dots as fluorescent probes for the determination of some pharmaceutically-important nitro compounds

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