Electrochemical and peroxidase-catalyzed oxidation of epinephrine

Goyal, Rajendra N.; Rana, Anoop Raj Singh; Chasta, Himanshu

doi:10.1016/j.electacta.2011.11.014

Cited by 16 publications

(8 citation statements)

References 41 publications

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“…The direct electro-oxidation of epinephrine frees two electrons per epinephrine molecule and produces faradic current between the gate electrode and the electrolyte. The direct electro-oxidation of epinephrine in PBS is given by the formula [39][40][41] epinephrineepinephrine quinone + 2H + + 2e À…”

Section: Working Principle Of Oect-based Epinephrine Sensorsmentioning

confidence: 99%

“…On the other hand, nanomaterials have been shown to be able to increase the sensitivity and decrease the detection limit of OECT-based biosensors. [26][27][28][29][40][41][42][43] Hence, the surface modification on the gate electrodes is important to the performance of the devices, which has been optimized in our experiments.…”

Section: Working Principle Of Oect-based Epinephrine Sensorsmentioning

confidence: 99%

“…Many approaches, including liquid chromatography (HPLC), 5,6 polarography, 7 and electrochemical methods, [8][9][10][11][12] have been successfully used in the analysis of epinephrine. 13 Compared with many techniques based on expensive and unportable instruments, electrochemical methods are convenient, cost effective and suitable for miniaturization.…”

Section: Introductionmentioning

confidence: 99%

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Highly-sensitive epinephrine sensors based on organic electrochemical transistors with carbon nanomaterial modified gate electrodes

Mak

Liao

et al. 2015

J. Mater. Chem. C

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Section: Working Principle Of Oect-based Epinephrine Sensorsmentioning

confidence: 99%

Section: Working Principle Of Oect-based Epinephrine Sensorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Highly-sensitive epinephrine sensors based on organic electrochemical transistors with carbon nanomaterial modified gate electrodes

Mak

Liao

et al. 2015

J. Mater. Chem. C

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“…EP acts as a cellular chemical messenger 11 , and many diseases are related to the change of its concentration. It is a hormone synthesized by the adrenal medulla of the adrenal glands 12 13 14 , it stimulates a series of actions of the sympathetic nervous system called “fight or flight” response 15 . EP controls the performance of the nervous system, and its abnormal levels affect the regulation of the blood pressure heart rate, and glycogen metabolism 8 16 .…”

mentioning

confidence: 99%

Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Mphuthi

Adekunle

Ebenso

2016

Sci Rep

109

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Glassy carbon electrode (GCE) was modified with metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, and the electrocatalytic properties were studied. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using FTIR, Raman and SEM techniques. The electrodes were characterized using cyclic voltammetry (CV) technique. The electrocatalytic behaviour of the electrode towards epinephrine (EP) and norepinephrine (NE) oxidation was investigated using CV and DPV. Result showed that GCE-MWCNT/Fe3O4/2,3-Nc, GCE-MWCNT/Fe3O429H,31H-Pc, GCE-MWCNT/ZnO/2,3-Nc and GCE-MWCNT/ZnO/29H,31H-Pc electrodes gave enhanced EP and NE current response. Stability study indicated that the four GCE-MWCNT/MO/Pc modified electrodes were stable against electrode fouling effect with the percentage NE current drop of 5.56–5.88% after 20 scans. GCE-MWCNT/Fe3O4/29H,31H-Pc gave the lowest limit of detection (4.6 μM) towards EP while MWCNT/ZnO/29H,31H-Pc gave the lowest limit of detection (1.7 μM) towards NE. The limit of detection and sensitivity of the electrodes compared well with literature. Electrocatalytic oxidation of EP and NE on GCE-MWCNT/MO/Pc electrodes was diffusion controlled with some adsorption of electro-oxidation reaction intermediates products. The electrodes were found to be electrochemically stable, reusable and can be used for the analysis of EP and NE in real life samples.

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“…The electrochemical redox reaction mechanism is shown in Scheme 2. [41][42][43] Fig. 3 shows the CV responses of ISP at bare GCE, MWCNT/GCE and Lac-SiSG/MWCNT/GCE.…”

Section: Electrochemistry Of Isoprenaline At Lac-sisg/mwcnt/ Gcementioning

confidence: 99%

Preparation, characterization and analytical application of an electrochemical laccase biosensor towards low level determination of isoprenaline in human serum samples

et al. 2014

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Electrochemical and peroxidase-catalyzed oxidation of epinephrine

Cited by 16 publications

References 41 publications

Highly-sensitive epinephrine sensors based on organic electrochemical transistors with carbon nanomaterial modified gate electrodes

Highly-sensitive epinephrine sensors based on organic electrochemical transistors with carbon nanomaterial modified gate electrodes

Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Preparation, characterization and analytical application of an electrochemical laccase biosensor towards low level determination of isoprenaline in human serum samples

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