Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Mphuthi, Ntsoaki; Adekunle, Abolanle S.; Ebenso, Eno E.

doi:10.1038/srep26938

Cited by 109 publications

(55 citation statements)

References 61 publications

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“…The analytical characteristics reported for the sensing devices developed here are comparable to the values in the literature for other modified GCE (Table ). Electrochemical sensors with incorporated iron oxide nanoparticles (Fe 3 O 4 ), plus MWCNT and phthalocyanines have higher limits of detection than the electrochemical sensors developed in this work. The best performing MWCNT/Fe 3 O 4 /phthalocyanine sensor presents a limit of detection that is higher by a factor of 3 than the highest value obtained in the current work.…”

Section: Resultsmentioning

confidence: 96%

“…Various methods, including liquid chromatography , spectrophotometry , flow injection analysis , chemiluminescence , capillary electrophoresis , and photokinetics have been reported for the determination of epinephrine. However, since epinephrine is easily oxidized, electrochemical methods constitute a quicker, cost‐effective, simple and more sensitive alternative, and have been amongst the most appealing and suitable techniques employed . Despite the advantages, the electrochemical determination of epinephrine can be a challenging task.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, epinephrine coexists in natural environments with other electroactive species such as ascorbic acid and uric acid, which oxidize at unmodified electrodes at almost the same potential, leading to poor selectivity and reproducibility . To overcome these limitations, the use of modified electrodes for monitoring epinephrine has been proposed .…”

Section: Introductionmentioning

confidence: 99%

“…For instance, poly(methylene blue)/MWCNT/GCE , poly(brilliant cresyl blue)/MWCNT/GCE , poly(malachite green)/MWCNT/GCE , poly(neutral red)/MWCNT/GCE and poly(brilliant cresyl blue)/graphene/GCE have been successfully applied as EP sensors. Carbon nanotube modified electrodes have also been prepared and used for EP detection, in combination with other components such as cyclodextrin , Nafion , hematoxylin , cobalt phthalocyanine , tyrosinase , dopamine dithiocarbamate , chitosan , and iron oxide nanoparticles (Fe 3 O 4 ) . Gold , ITO and graphene modified electrodes are further attempts to the fabrication of EP electrochemical sensors.…”

Section: Introductionmentioning

confidence: 99%

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Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine

Tomé

Brett

2019

Electroanalysis

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Novel electrochemical sensors for epinephrine (EP) based on a glassy carbon electrode (GCE) modified with a redox polymer film and iron (III) oxide nanoparticles (Fe2O3NP) have been developed. Two redox polymers‐poly(brilliant cresyl blue) (PBCB) and poly(Nile blue) (PNB), and two different architectures‐polymer/Fe2O3/GCE and Fe2O3/polymer/GCE were investigated. The electrochemical oxidation of epinephrine at the modified electrodes was performed by differential pulse voltammetry (DPV), in pH 7 electrolyte, and the analytical parameters were determined. The results show enhanced performance, more sensitive responses and lower detection limits at the modified electrodes, compared to other electrochemical epinephrine sensors reported in the literature. The best voltammetric response with the lowest detection limit was obtained for the determination of epinephrine at PBCB/Fe2O3/GCE. The novel sensors are reusable, with good reproducibility and stability, and were successfully applied to the determination of epinephrine in commercial injectable adrenaline samples.

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine

Tomé

Brett

2019

Electroanalysis

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“…Recently, there has been an increasing interest in the application of methods based on nanoparticles to determine the level of neurotransmitters with special focus on catecholamine detection. Accordingly, a successful determination of dopamine (DA), epinephrine (EP) as well as norepinephrine (NE) levels using tools based on nanomaterials has also been reported. Mostly, in these procedures enzymes are successfully used as a biologically active material.…”

Section: Introductionmentioning

confidence: 99%

Graphene Quantum Dots‐based Electrochemical Biosensor for Catecholamine Neurotransmitters Detection

2018

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An useful electrochemical sensing approach was developed for epinephrine (EP) detection based on graphene quantum dots (GQDs) and laccase modified glassy carbon electrodes (GC). The miniature GC biosensor was designed and constructed via the immobilization of laccase in an electroactive layer of the electrode coated with carbon nanoparticles. This sensing arrangement utilized the catalytic oxidation of EP to epinephrine quinone. The detection process was based on the oxidation of catecholamine in the presence of the enzyme – laccase. With the optimized conditions, the analytical performance demonstrated a high degree of sensitivity −2.9 μA mM−1 cm−2, selectivity in a broad linear range (1–120×10−6 M) with detection limit of 83 nM. Moreover, the method was successfully applied for EP determination in labeled pharmacological samples.

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Conductive Polymer Enabled Biostable Liquid Metal Electrodes for Bioelectronic Applications

Lim

Kim

Akbarian

et al. 2022

Adv Healthcare Materials

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Gallium (Ga)-based liquid metal materials have emerged as a promising material platform for soft bioelectronics. Unfortunately, Ga has limited biostability and electrochemical performance under physiological conditions, which can hinder the implementation of its use in bioelectronic devices. Here, an effective conductive polymer deposition strategy on the liquid metal surface to improve the biostability and electrochemical performance of Ga-based liquid metals for use under physiological conditions is demonstrated. The conductive polymer [poly(3,4-ethylene dioxythiophene):tetrafluoroborate]-modified liquid metal surface significantly outperforms the liquid metal.based electrode in mechanical, biological, and electrochemical studies. In vivo action potential recordings in behaving nonhuman primate and invertebrate models demonstrate the feasibility of using liquid metal electrodes for high-performance neural recording applications. This is the first demonstration of single-unit neural recording using Ga-based liquid metal bioelectronic devices to date. The results determine that the electrochemical deposition of conductive polymer over liquid metal can improve the material properties of liquid metal electrodes for use under physiological conditions and open numerous design opportunities for next-generation liquid metal-based bioelectronics.

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Electrocatalytic oxidation of Epinephrine and Norepinephrine at metal oxide doped phthalocyanine/MWCNT composite sensor

Cited by 109 publications

References 61 publications

Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine

Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine

Graphene Quantum Dots‐based Electrochemical Biosensor for Catecholamine Neurotransmitters Detection

Conductive Polymer Enabled Biostable Liquid Metal Electrodes for Bioelectronic Applications

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