Electrocardiogram Delineation in a Wistar Rat Experimental Model

Abstract

Background and Objectives The extensive use of electrocardiogram (ECG) recordings during experimental protocols using small rodents requires an automatic delineation technique in the ECG with high performance. It has been shown that the wavelet transform (WT) based ECG delineator is a suitable tool to delineate electrocardiographic waveforms. The aim of this work is to implement and evaluate the ECG waves delineation in Wistar rats applying WT. We also describe the ECG signal of the Wistar rats giving the characteristics of its spectrum among other useful information. Methods We evaluated a delineator based on WT in a Wistar rat electrocardiograms database which was annotated manually by experienced observers. Results The delineation showed an “overall performance” such as sensitivity and a positive predictive value of 99.2% and 83.9% for P-wave, 100% and 99.9% for QRS complex, and 100% and 99.8% for T-wave, respectively. We also compared temporal analysis based ECG delineator with the WT based ECG delineator in RR interval, QRS duration, QT interval, and T-wave peak-to-end duration. The results showed that WT outperforms the temporal delineation technique in all parameters analyzed. Conclusions Finally, we propose a WT based ECG delineator as a methodology to implement in a wide diversity of experimental ECG analyses using Wistar rats.

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“…In addition, the signal must be assessed qualitatively for rhythm disturbances in addition to the qualitative measures of heart rate. 67,68 • Evaluate the QRS complex. If the QRS complex appears of normal height and duration, then the initiating impulse originates above the A-V node.…”

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